New drug candidate CBX-12 tested in patients with Hard-to-Treat cancers

NCT ID NCT04902872

First seen Jun 27, 2026 ยท Last updated Jun 27, 2026

Summary

This study tested an experimental drug called CBX-12 in 69 adults with advanced solid tumors (like ovarian, lung, breast, or colon cancer) that had stopped responding to standard therapies. The main goals were to check the drug's safety, find the best dose, and see if it could shrink tumors. The study was completed, but results are not yet reported.

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Conditions

The condition(s) this trial relates to.

appendiceal neoplasm appendix cancer breast cancer breast neoplasm Carcinoma, Ovarian Epithelial colorectal cancer colorectal neoplasm esophageal cancer Esophageal Neoplasms gastric cancer gastric neoplasm malignant pancreatic neoplasm metastatic malignant neoplasm non-small cell lung carcinoma ovarian carcinoma pancreatic neoplasm sarcoma small cell lung carcinoma transitional cell carcinoma urothelial carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • MD Anderson Cancer Center

    Houston, Texas, 77030, United States

  • NEXT Oncology

    Austin, Texas, 78758, United States

  • NEXT Oncology

    San Antonio, Texas, 78229, United States

  • Yale Cancer Center

    New Haven, Connecticut, 06511, United States