PANCREAS CANCER

This study tests a new drug, KESONOTIDE™, in people with advanced solid tumors like prostate, breast, lung, ovarian, pancreatic, skin cancer, or glioblastoma. The main goal is to check if the drug is safe and tolerable, and to find the right dose. About 80 adults will take part i…

This early-stage study tests whether adding a procedure called irreversible electroporation (IRE) to standard chemotherapy can help control locally advanced pancreatic cancer. IRE uses short electric pulses to destroy cancer cells without harming nearby tissues. About 20 adults w…

This study tests whether adding two targeted drugs (defactinib and avutometinib) to a precise form of radiation therapy can help people with advanced pancreatic cancer live longer without their disease getting worse. About 36 adults whose cancer is locally advanced or borderline …

This study tests a new drug called CNSI-Fe(II), which is injected directly into tumors. It uses iron to trigger a type of cell death called ferroptosis, aiming to control or shrink advanced solid tumors like lung, pancreas, and colorectal cancers. The study involves 54 adults who…

This study tests a new treatment for people with advanced pancreatic cancer that cannot be removed by surgery or has spread. The treatment uses a patient's own immune cells, which are mixed with a special antibody to help them attack cancer cells. Up to 23 participants will recei…

This early-stage study tests a new treatment using a patient's own immune cells, engineered to target a protein called CEA found on certain cancer cells. It is for adults with advanced lung, stomach, colon, rectal, esophageal, or pancreatic cancer who have not responded to standa…

This study tests a new type of CAR T cell therapy for adults with advanced solid tumors (like colorectal, lung, or pancreatic cancer) that have lost a specific marker on their cells. The treatment uses the patient's own immune cells, modified to target cancer cells while protecti…

This early-stage trial tests whether adding Tumor Treatment Fields (TTF) – a device that sends low-intensity electric fields to the tumor – to a three-drug chemotherapy regimen can help control metastatic pancreatic cancer. About 40 adults whose cancer has spread to the liver wil…

This study tests a new gene therapy for people with pancreatic cancer that has returned after standard treatment. The therapy uses the patient's own immune cells, modified to target a protein called B7-H3 on cancer cells, and includes a safety switch to control side effects. The …

This early-phase study tests whether injecting a medical glue into the pancreas during surgery can strengthen the connection between the pancreas and intestine, reducing the risk of a dangerous leak. The study involves 30 adults with pancreatic or nearby cancers who are undergoin…

This study tests whether using multiple treatments together (like surgery, radiation, and chemotherapy) can help people with pancreatic cancer that has spread to only a few spots in the body live longer. About 80 adults with this type of cancer will be randomly assigned to get ei…

This early-phase study tests a new treatment for people with metastatic pancreatic or breast cancer that has stopped responding to standard therapies. The treatment combines two chemotherapy drugs with high-dose vitamins and a stem cell transplant to help the body recover. The ma…

This study tests whether adding tumor treating fields (TTF) to targeted radiation therapy can slow tumor growth in people with locally advanced pancreas cancer. Participants receive radiation for five days and wear a device that delivers low-intensity electric fields for at least…

This study tests if axelopran, a drug typically used for opioid-induced constipation, can help slow tumor growth in people with advanced breast, lung, pancreas, or prostate cancer. About 34 adults whose cancer has worsened after standard treatment will take axelopran capsules dai…

This study tests whether adding a medical glue (Glubran 2) to the surgical connection in the pancreas can prevent a serious complication called pancreatic fistula, which is a leak of digestive fluids. About 100 adults having their pancreas removed due to cancer will be randomly a…

This study tests a high-dose, short-course radiation treatment for people with locally advanced pancreatic cancer that cannot be removed by surgery. The goal is to see if this approach can control tumor growth in the treated area for at least two years. About 30 participants will…

This study is testing an experimental drug called MGC026 in about 250 adults with advanced solid tumors that have not responded to other treatments. The main goals are to check the drug's safety and find the right dose. Participants receive the drug by IV and are closely monitore…

This study tests a new radiation technique called SMART, which uses MRI to guide and adapt radiation beams in real time. It aims to improve tumor control and reduce side effects for people with cancers of the pancreas, lung, kidney, prostate, liver, and others. About 400 particip…

This study tests a device that uses sound waves (histotripsy) to break apart pancreatic tumors without surgery. It includes 50 adults with advanced pancreatic cancer that cannot be removed. The main goal is to check if the procedure is safe and to track any complications within 3…

This study tests if injecting a medical glue into the pancreas during surgery can prevent fluid leaks, a common and serious complication. About 90 adults with pancreatic or nearby cancers who are having a Whipple procedure will be randomly assigned to receive the glue injection o…

This study tests a special PET scan probe called [68Ga]CBP8 to see if it can detect early signs of radiation damage in lung and pancreatic cancer patients. About 72 adults who are getting radiation therapy will have scans before and 3-6 months after treatment. The goal is to find…

This study tests whether a digital app (Open Food Facts) plus nutrition education can help 170 people at high risk for breast, pancreas, colon cancer, or with Lynch syndrome or BRCA mutations improve their diet quality. Participants will use the app to reduce ultra-processed food…

This study tests whether using virtual reality (VR) can reduce severe belly pain in people with digestive tract cancers. 360 participants will be split into three groups: one using skills-based VR, one using distraction VR, and a sham control group. Researchers will track pain, a…

This study is looking at tiny pieces of tumor DNA found in the blood (ctDNA) of people with pancreatic cancer that can be removed by surgery. The goal is to see how often ctDNA is present and whether it relates to how long patients live. About 50 adults with early-stage pancreati…

This study creates a registry of people with pancreatic diseases or a high risk for pancreatic cancer, such as those with a family history or certain genetic mutations. Researchers will collect medical information and blood samples to study how these conditions develop over time.…

This study looks at certain proteins called convertases in pancreatic tumor samples from 50 patients. Researchers want to see if these proteins can help predict how the disease will progress. No new treatments are tested; the goal is to gather information that could improve futur…

This study looks at whether a blood or stool test that detects tumor DNA (called ctDNA) can help doctors better manage gastrointestinal cancers like pancreas, colon, and bile duct cancer. About 100 adults with these cancers will provide samples, and researchers will track surviva…

This observational study collects tumor tissue and blood cells from 200 adults with advanced solid tumors like colorectal, lung, or pancreatic cancer. The goal is to understand how often tumors lose a specific marker (HLA) and to store participants' own T cells for possible futur…

This study collects blood samples from 30 adults with pancreatic cancer to build a research database. The goal is to store samples and health information for future studies on circulating biomarkers. Participants must be patients at the University of Pennsylvania and able to give…

This study is testing a new way to find early signs of pancreas cancer in people at high risk, such as those with a strong family history or certain gene mutations. Researchers will collect and analyze pancreatic juice during a routine endoscopy to look for cancer markers. The go…

This study collects tumor and nearby normal tissue samples from people already scheduled for surgery or biopsy at the NIH Clinical Center. Up to 1,800 adults and children (age 2+) with solid tumors can join. The samples are used to identify new molecular targets for future cancer…

This study follows 5,000 adults with pancreatic cysts to learn how these cysts behave over time. Researchers aim to create a better way to tell which cysts are harmless and which may turn into cancer. Participants provide medical records and samples, helping doctors improve early…

This study aims to find better ways to detect pancreatic cancer early in people who are at higher risk due to family history or certain gene changes. Researchers will follow 20,000 volunteers over time to see who develops the disease. The goal is to improve screening and preventi…

This study aims to understand how the tumor's surroundings change during chemoradiotherapy for locally advanced cervical and pancreatic cancers. Researchers will collect tissue samples, blood, and imaging data from 60 participants before, during, and after treatment. The goal is …