MRI-Guided radiation aims to hit tumors harder, spare healthy tissue
NCT ID NCT04115254
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This master trial is testing a new radiation technique called SMART, which uses MRI to guide and adapt radiation beams in real time. The goal is to deliver high doses precisely to tumors while protecting nearby organs. The study enrolls adults with various cancers (pancreas, lung, kidney, prostate, liver, and others) and has two phases: Phase I checks if the treatment is safe and feasible, and Phase II looks at how well it controls tumors and improves patient quality of life.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
MR-guided radiation therapy (SMART)
What this could lead to
If successful, this could show that SMART is a safe and effective way to deliver high-precision radiation to many types of tumors, potentially improving tumor control and reducing side effects.
What could go wrong
This is an early-phase trial (Phase I/II) with no control group, so results may not prove superiority over standard radiation. Side effects from high-dose radiation are possible, and success in one tumor type may not apply to others.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Brigham & Women's Hospital
RECRUITINGBoston, Massachusetts, 02115, United States
Contact
Contact
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Dana Farber Cancer Institute
RECRUITINGBoston, Massachusetts, 02115, United States
Contact
Contact