RENAL CANCER

This study tests whether giving two drugs (pembrolizumab and axitinib) before surgery can shrink tumor-related blood clots in the main vein of people with kidney cancer. The goal is to make surgery easier and safer, and to improve long-term outcomes. About 17 adults with clear ce…

This study tests a new medicine, PF-08634404, for adults with advanced kidney cancer that has spread. The goal is to see if the drug, given alone or with other cancer treatments, can shrink tumors and is safe. Participants must not have had prior treatment for their advanced canc…

This early-phase trial tests a new drug called MDX2001 in people with advanced solid tumors that have spread. The main goals are to check the drug's safety and see if it can shrink tumors. About 285 adults with various cancers like lung, breast, or colon cancer will take part.

This study tests a new drug, BL-B01D1, combined with standard targeted therapy (TKI) and sometimes an immunotherapy (pembrolizumab) for people with advanced kidney cancer that has spread. The goal is to see if the combination shrinks tumors and how safe it is. About 260 adults ag…

This study looks at whether a precise, high-dose radiation treatment called SBRT can control or eliminate kidney cancer in patients who are not candidates for surgery due to age, frailty, or other health risks. About 53 participants with early-stage kidney cancer will receive SBR…

This study tests a new radiation technique called SMART, which uses MRI to guide and adapt radiation beams in real time. It aims to improve tumor control and reduce side effects for people with cancers of the pancreas, lung, kidney, prostate, liver, and others. About 400 particip…

This early-stage study tests a new drug, NXP900, in about 140 adults with advanced solid tumors (like lung, kidney, or mesothelioma) that have not responded to standard treatments. The goal is to find a safe dose and see if the drug can shrink tumors. Participants will receive NX…

This study tests a new way to remove small kidney tumors using a robot, without clamping the kidney's blood supply or using stitches. The goal is to preserve as much healthy kidney function as possible. About 190 adults with tumors up to 7 cm will be enrolled to see if this techn…

This study aims to see if a special PET scan (68Ga-PSMA) is better than standard CT scans at finding where kidney cancer has spread in the body. About 300 adults with advanced kidney cancer will receive both scans, and doctors will compare the results. If the PET scan proves more…

This study tests a new type of PET scan that targets a protein called CD70, which is found on some cancer cells. The goal is to see if this scan can better detect kidney cancer, lymphoma, and nasopharyngeal cancer compared to standard scans. About 300 adults with known or suspect…

This study is testing a blood test that looks for DNA signals from 20 different cancers, including breast, lung, and colon cancer. Researchers want to see if the test can find cancer early, detect any cancer left after treatment, and catch a relapse before symptoms appear. About …

This study tests a new radioactive tracer called 64Cu-GRIP B that lights up immune activity in PET scans. It aims to see if the tracer is safe and can help detect which advanced cancers (like prostate, kidney, or bladder) are more likely to respond to immunotherapy. About 91 adul…

This study tests whether a spinal injection of morphine before robotic kidney surgery helps patients feel better the day after compared to a lidocaine drip during surgery. About 220 adults having robotic upper urinary tract surgery will be randomly assigned to one of the two pain…

This study tests whether non-steroidal anti-inflammatory drugs (NSAIDs) can effectively control pain after robotic kidney cancer surgery, reducing the need for stronger opioid painkillers. About 110 adults undergoing this surgery will be randomly assigned to receive either NSAIDs…

This study collects DNA and health information from 750 people with kidney cancer, their family members, and healthy volunteers. The goal is to build a database that helps researchers find better ways to prevent, detect, and treat kidney cancer. Participants provide a blood or sa…

This study looks at how hospitals across the country handle patients who are admitted with blood in their urine (hematuria). Researchers will track over 1,000 patients to see what tests and treatments they receive, how long they stay in the hospital, and their outcomes. The goal …

This study collects extra blood, urine, and tumor samples from children and adults with childhood cancers (like leukemia or sarcoma) to create a large tissue repository. Researchers will use these samples to study the genetic and molecular makeup of these cancers. The goal is to …

This study aims to help people with small kidney tumors (up to 4 cm) make informed decisions about their treatment. Researchers will develop a decision aid that explains the benefits and risks of each option based on the patient's own situation. About 40 adults will use the tool …

This study aims to uncover the genetic roots of lymphomas, leukemias, multiple myeloma, and similar diseases by collecting DNA and blood samples from people who have these conditions and their family members. Researchers will analyze the samples to find genes that increase the ri…

This study looks at whether watching a video before genetic testing helps people with certain cancers understand their hereditary risk better. About 1020 adults with breast, ovarian, pancreatic, prostate, colorectal, renal, melanoma, or sarcoma cancers will take part. Researchers…

This study looks at 300 women aged 50 and older who have blood in their urine along with a bladder infection. Researchers want to see if these women need the full set of cancer tests (like a camera in the bladder and CT scans) or if they can safely skip them. The goal is to find …

This study is testing a new type of CT scan that takes pictures during cancer treatments like embolization or ablation for liver and kidney tumors. The goal is to see if the scan provides better images and helps doctors guide the procedure more accurately. About 30 adults with tu…

This study collects blood, urine, saliva, and tissue samples from people who have or may have cancer, as well as their blood relatives. The goal is to help researchers learn more about the genetic and molecular causes of cancer. No direct treatment is given, but the samples may l…

This study looks at how urological diseases and their treatments impact patients' work life. Researchers will survey 2000 adults admitted to a hospital in Poland, focusing on those who have major cancer surgeries or stone procedures. Participants will report their job status and …