RENAL CANCER

This study tests a new medicine, PF-08634404, in adults with advanced kidney cancer that has spread. The goal is to see if the drug is safe and can shrink tumors when used alone or with other cancer drugs. About 224 participants who have not had prior treatment for their advanced…

This study tests a new drug called MDX2001 in people with advanced solid tumors that have spread. The main goals are to check the drug's safety and see if it can shrink tumors. About 285 adults with various cancers like lung, breast, or colon cancer will take part. This is an ear…

This study tests whether giving two drugs (pembrolizumab and axitinib) before surgery can shrink a tumor-related blood clot in the main vein of the abdomen in people with kidney cancer. The goal is to make surgery safer and improve long-term outcomes. About 17 adults with clear c…

This study tests a new oral drug called NXP900 in people with advanced solid tumors (like lung, kidney, or mesothelioma) that have not responded to standard treatments. The trial has two parts: first, finding the right dose, and then seeing if the drug shrinks tumors. It is a fir…

This study looks at using a high-dose, targeted radiation therapy (SBRT) to treat kidney cancer in people who are too frail or at high risk for surgery. About 53 participants will receive this non-invasive treatment, which does not require anesthesia or a hospital stay. The goal …

This study tests a new drug (BL-B01D1) combined with a standard targeted therapy (TKI), with or without an immunotherapy (pembrolizumab), in 260 adults with advanced kidney cancer that has spread. The goal is to see if these combinations shrink tumors and are safe. Participants m…

This master trial is testing a new radiation technique called SMART, which uses MRI to guide and adapt radiation beams in real time. The goal is to deliver high doses precisely to tumors while protecting nearby organs. The study enrolls adults with various cancers (pancreas, lung…

This study tests a new surgical technique for removing small kidney tumors (up to 7 cm) using a robot. Instead of clamping the kidney's blood supply and stitching the wound closed, surgeons avoid clamping and use heat and special materials to stop bleeding. The goal is to preserv…

This study tests a special PET/CT scan that uses radioactive tracers to find cancers that have a protein called CD70 on their surface. The cancers being studied include kidney cancer, lymphoma, and nasopharyngeal cancer. About 300 adults will receive an injection of the tracer an…

This phase I/II trial tests a radioactive tracer called 64Cu-GRIP B, which targets granzyme B—a substance released by immune cells. By using PET scans, researchers hope to see immune activity in tumors and predict whether immunotherapy will work. The study involves about 91 adult…

This study compares a special PET scan (68Ga-PSMA) with standard CT scans to see which better detects where kidney cancer has spread in 300 adults with advanced disease. Participants will receive both scans, and doctors will check if the PET scan changes treatment plans. The goal…

This study is testing a blood test that looks for DNA signals from 20 different cancers, including lung, breast, and colon cancer. Researchers will see if the test can find cancer early, detect any cancer left after treatment, and catch a relapse before it shows up on scans. The …

This Phase 3 trial tests whether a single spinal injection of morphine and bupivacaine before robotic kidney or ureter surgery leads to better recovery than an intravenous lidocaine drip during surgery. About 220 adults scheduled for robotic upper urinary tract surgery will be ra…

This study tests whether a non-steroidal anti-inflammatory drug (NSAID) called ketorolac can control pain after robotic kidney surgery better than standard opioids. About 110 adults having a partial nephrectomy for kidney cancer will be randomly assigned to receive either ketorol…

This study collects extra blood, urine, and tumor samples from children and adults with certain cancers to build a large tissue repository. Researchers will analyze these samples to learn more about the genetic and molecular makeup of these tumors. The goal is to support future s…

This study collects blood, urine, saliva, and tissue samples from nearly 6,000 people who have or may have cancer, including rare inherited forms. The samples are stored and used for research to understand the genetic and molecular basis of cancer. No new treatment is being teste…

This study is looking for certain cells in the blood of people with 9 types of advanced cancers that have spread. Researchers will take one blood sample from each of 450 participants before they start a new treatment. They will use two different lab methods to see if they can fin…

This study is testing whether an 8-minute educational video can effectively prepare cancer patients for genetic testing, compared to standard genetic counseling. Over 1,000 adults with various cancers will participate. The goal is to see if the video is acceptable and improves un…

This study is creating a registry of DNA and health information from 750 people with kidney cancer, their family members, and healthy volunteers. Researchers will use this data to better understand the genetics of kidney cancer, with the goal of improving prevention, diagnosis, a…

This study looks at how urological diseases and their treatments impact patients' work life. Researchers will survey 2,000 adults admitted to a hospital in Poland, focusing on those having major cancer surgeries or stone procedures. Participants will be followed for 6 months to t…

This study watches how hospitals handle patients admitted with blood in their urine (hematuria). It will track things like how long people stay in the hospital and how quickly they get a diagnosis. The goal is to find the best ways to manage this condition and create guidelines f…

This study aims to find the genetic causes of certain blood cancers like lymphoma, leukemia, and multiple myeloma by studying families where more than one person has the disease. Researchers will collect DNA and blood samples from up to 500 participants, including patients and th…

This study tests a new type of CT scan used during procedures to treat liver and kidney cancers. About 30 adults with tumors larger than 1.5 cm will be enrolled. The goal is to see if the scan provides clearer images and helps doctors guide treatments more accurately.

This study tests a web-based decision aid for people with small kidney tumors (up to 4 cm). The tool provides personalized information about treatment options and their risks and benefits. Researchers will enroll 40 patients to see if the tool improves knowledge, satisfaction, an…

This study looks at women aged 50 and older who have visible blood in their urine along with a bladder infection. Researchers want to find out if these women really need to undergo invasive tests like cystoscopy and CT scans to check for bladder or kidney cancer. By following 300…