Can NSAIDs replace opioids after kidney surgery?
NCT ID NCT05842044
First seen Jun 26, 2026 · Last updated Jun 26, 2026
Summary
This study tests whether a non-steroidal anti-inflammatory drug (NSAID) called ketorolac can control pain after robotic kidney surgery better than standard opioids. About 110 adults having a partial nephrectomy for kidney cancer will be randomly assigned to receive either ketorolac or a placebo, along with standard painkillers like acetaminophen and oxycodone as needed. The main goal is to see if NSAIDs reduce the need for opioids and their side effects.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Ketorolac (an NSAID painkiller)
What this could lead to
If it works, this could show that NSAIDs are a safe and effective alternative to opioids for managing pain after kidney surgery, reducing reliance on strong painkillers.
What could go wrong
This is a small, early-phase trial (110 people) at one center, so results may not apply broadly. NSAIDs carry risks like bleeding or kidney issues, especially after kidney surgery.
Disclaimer
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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University of Miami
RECRUITINGMiami, Florida, 33136, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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