Can NSAIDs replace opioids after kidney surgery?

NCT ID NCT05842044

Recruiting now Symptom relief Sponsor: University of Miami Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 26, 2026

Summary

This study tests whether a non-steroidal anti-inflammatory drug (NSAID) called ketorolac can control pain after robotic kidney surgery better than standard opioids. About 110 adults having a partial nephrectomy for kidney cancer will be randomly assigned to receive either ketorolac or a placebo, along with standard painkillers like acetaminophen and oxycodone as needed. The main goal is to see if NSAIDs reduce the need for opioids and their side effects.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Ketorolac (an NSAID painkiller)
What this could lead to: If it works, this could show that NSAIDs are a safe and effective alternative to opioids for managing pain after kidney surgery, reducing reliance on strong painkillers.
What could go wrong: This is a small, early-phase trial (110 people) at one center, so results may not apply broadly. NSAIDs carry risks like bleeding or kidney issues, especially after kidney surgery.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for KIDNEY CANCER are added.

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

kidney cancer kidney neoplasm renal carcinoma renal cell carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

KIDNEY CANCER RENAL CANCER RENAL NEOPLASM

Contacts and locations

Locations

University of Miami
RECRUITING

Miami, Florida, 33136, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.