Drug combo shrinks kidney cancer clots before surgery in new trial

NCT ID NCT05969496

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether giving two drugs (pembrolizumab and axitinib) before surgery can shrink a tumor-related blood clot in the main vein of the abdomen in people with kidney cancer. The goal is to make surgery safer and improve long-term outcomes. About 17 adults with clear cell kidney cancer and a clot in the inferior vena cava will receive the drugs for 12 weeks before their planned kidney removal surgery.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

kidney cancer renal carcinoma renal cell carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • Hilands Ranch Hospital

    RECRUITING

    Highlands Ranch, Colorado, 80129, United States

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Lone Tree Medical Center

    RECRUITING

    Lone Tree, Colorado, 80124, United States

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • University of Colorado Cancer Center

    RECRUITING

    Aurora, Colorado, 80045, United States

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact