Drug combo shrinks kidney cancer clots before surgery in new trial

NCT ID NCT05969496

Recruiting now Disease control Sponsor: University of Colorado, Denver Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether giving two drugs (pembrolizumab and axitinib) before surgery can shrink a tumor-related blood clot in the main vein of the abdomen in people with kidney cancer. The goal is to make surgery safer and improve long-term outcomes. About 17 adults with clear cell kidney cancer and a clot in the inferior vena cava will receive the drugs for 12 weeks before their planned kidney removal surgery.

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Conditions

The condition(s) this trial relates to.

kidney cancer renal carcinoma renal cell carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

INFERIOR VENA CAVA THROMBOSIS KIDNEY CANCER RENAL CANCER RENAL CELL CARCINOMA

Contacts and locations

Locations

Hilands Ranch Hospital
RECRUITING

Highlands Ranch, Colorado, 80129, United States
Lone Tree Medical Center
RECRUITING

Lone Tree, Colorado, 80124, United States
University of Colorado Cancer Center
RECRUITING

Aurora, Colorado, 80045, United States

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