RENAL CELL CARCINOMA

This study is testing if giving a higher dose of the drug cabozantinib can help control advanced kidney cancer in patients whose cancer has started growing again while on the standard dose. The trial will enroll 18 adults with advanced kidney cancer who previously benefited from …

This study is testing a combination of three drugs—nivolumab, ipilimumab, and cabozantinib—to see if they can safely slow or stop the growth of kidney cancer that has spread to the brain. It is for adults with this specific type of cancer who have not yet received treatment for t…

This early-stage trial is testing a new oral medication called BMS-986506 for people with advanced kidney cancer. The main goal is to determine if the drug is safe and tolerable for patients who have already tried other treatments. Researchers will enroll 125 participants to find…

This early-stage study aims to find a safe and effective dose of a new drug called AZD6750, which is designed to boost the immune system to fight cancer. It will test the drug alone and combined with other cancer treatments in about 60 adults with advanced or spreading solid tumo…

This early-stage trial is testing whether adding a pill called ruxolitinib to an immunotherapy drug (retifanlimab) is safe and can help control advanced lung or kidney cancer that has started growing again after prior immunotherapy. The study will enroll about 40 participants to …

This trial is testing if a drug called alectinib, already approved for a type of lung cancer, can help treat other rare cancers that share the same genetic change (ALK mutation). It will involve about 30 adults and children with various rare or hard-to-treat cancers. The goal is …

This study is testing whether giving two cancer drugs (axitinib and a PD-1 antibody) before surgery can help stop kidney cancer from returning. It will involve 298 patients with high-risk kidney cancer who are scheduled for surgery. Patients will be randomly assigned to receive e…

This study is for people with advanced kidney cancer whose immunotherapy is working for most of their body, but a few tumors (1-5) have started growing again. It tests whether using very precise, high-dose radiation to treat just those few growing tumors can help patients continu…

This study is testing a more precise way to deliver radiation therapy to people whose lung cancer, melanoma, or kidney cancer has spread to a few new spots. It uses PET scans to guide the radiation beams to the most active parts of the tumors. The goal is to see if this targeted …

This study is testing whether combining the drugs tivozanib and nivolumab can help control advanced non-clear cell kidney cancer. It will enroll about 48 adults with this specific type of cancer who have had up to one prior treatment. The main goals are to see if the combination …

This study aims to find out if cooling the kidney with ice slush during robotic surgery to remove part of a cancerous kidney helps it recover better than keeping it warm. Researchers will randomly assign 310 patients to either the cold or warm technique and compare how well kidne…

This study is for people with advanced kidney cancer that has come back after initial treatment. It aims to see if a new combination of two drugs, belzutifan and zanzalintinib, helps people live longer and keeps the cancer from worsening better than the current standard drug, cab…

This study is testing if a new drug called HLX17 works similarly to the established cancer drug Keytruda. It aims to prevent cancer from returning in people who have had surgery for certain lung, skin, or kidney cancers. Researchers will compare how the two drugs are processed by…

This study is testing new combinations of experimental drugs for people with a type of kidney cancer that has come back after initial treatment with immunotherapy. The main goals are to see if these drug combinations are safe and if they can shrink or control the cancer. The stud…

This study is testing a new oral medication called Alintegimod, given alongside the immunotherapy drugs ipilimumab and nivolumab. It aims to see if this combination is safe and can help control advanced cancers that have spread or returned after other treatments. The study will e…

This study is testing whether combining two drugs, Envafolimab and Lenvatinib, can help control advanced cancers like lung, kidney, and liver cancer that have progressed after standard treatments. The goal is to see if this combination is safe and can shrink tumors better than cu…

This study is testing a new oral medication called NEO212 for adults with specific aggressive brain tumors (like glioblastoma) or brain metastases from other cancers. The main goals are to find a safe and effective dose, see how the body processes the drug, and check if it can he…

This study is testing a new combination of three drugs to see if they can safely control advanced kidney cancer that has spread. The trial will enroll about 25 adults with specific types of advanced kidney cancer who have not yet received treatment for their metastatic disease. R…

This study is testing a new, experimental drug called GI-101 in people with advanced cancers that have spread. The main goals are to find a safe dose and see if the drug, given alone or with other approved cancer medicines, can help shrink tumors. The trial will enroll about 317 …

This study is testing whether giving cancer drugs before surgery can help the immune system fight kidney cancer. About 30 patients with high-risk kidney cancer will receive either pembrolizumab alone or pembrolizumab combined with lenvatinib before their tumor is removed. The mai…

This study is testing a new type of radiation therapy called lattice radiation (LRT) for people with large cancer tumors that have spread to soft tissues. It compares LRT to standard radiation to see which is better at shrinking tumors and attracting immune cells to fight the can…

This study is testing whether adding a specialized form of radiation therapy can help control advanced kidney cancer that has started growing again after initial immunotherapy treatments. It will involve about 35 patients whose cancer has spread to multiple sites. The main goal i…

This study is testing if combining immunotherapy drugs (called PD-1/PD-L1 inhibitors) with targeted radiation is more effective for controlling several advanced cancers, including lung and head/neck cancers. It aims to help patients live longer and also tries to find patterns in …

This study is testing a personalized approach to treatment after surgery for kidney cancer. It uses a special blood test to look for tiny traces of leftover cancer. Patients who test negative for this 'molecular residual disease' will skip standard follow-up drug treatment, while…

This is the first study in people testing a new oral drug called NEO-811 for advanced kidney cancer that has spread or cannot be removed by surgery. The main goals are to find a safe dose and see how the body handles the drug. It is for patients whose cancer has continued to grow…

This study is testing a new type of cell therapy called A2B395 for adults with advanced solid tumors that have spread or returned. The therapy uses modified immune cells designed to specifically kill cancer cells while protecting the patient's healthy cells. The main goals are to…

This is the first study in people for a new radioactive drug called [225Ac]-FPI-2068. It aims to find a safe dose and see how the drug travels in the body of 70 adults with advanced solid tumors that have stopped responding to standard treatments. The main goal is to check safety…

This study is testing whether giving two immunotherapy drugs, cemiplimab and fianlimab, before surgery to remove a kidney is a safe and practical approach. The goal is to see if this treatment can shrink the tumor before the operation. It is for a small group of 10 people with hi…

This study compares two radiation methods for patients whose cancer has spread to the brain and who are receiving immunotherapy. Researchers want to see if giving smaller radiation doses over several days causes fewer side effects than the standard single-day treatment. The trial…

This first-in-human study is testing an experimental cancer treatment called IDOV-Immune, which uses a modified virus designed to infect and destroy cancer cells while boosting the immune system. The trial aims to find the safest dose and check for early signs that the treatment …

This study is testing whether giving a cancer immunotherapy treatment called nivolumab as an injection at home is a safe and practical alternative to receiving it at a clinic. It aims to see if home treatment reduces the burden of travel and improves quality of life for patients …

This study aims to see how well the drug T-DXd works in real-world settings for patients with advanced HER2-positive cancers who have already tried other treatments and have no good options left. It will follow about 100 patients with various solid tumors (excluding breast, lung,…

This is the first study in people for a new oral drug called DCC-2812. It aims to find a safe dose and see if it can help control advanced kidney, bladder, or prostate cancer that has spread. The study will enroll about 60 people to check for side effects and see if the drug show…

This is the first human study of an experimental drug called JANX008 for people with advanced solid tumors that have spread and stopped responding to standard treatments. The main goal is to find a safe dose and understand how the body handles the drug. Researchers will also look…

This study is testing a combination of three drugs—bevacizumab, erlotinib, and atezolizumab—to see if they can control or shrink advanced kidney cancers linked to a hereditary condition (HLRCC) or a specific type called papillary renal cell cancer. The trial aims to enroll 65 pat…

This is a very early, small study to see if a new type of immune cell therapy is safe and possible to give to people. It will test a treatment made from a patient's own 'natural killer' immune cells, which are collected and specially prepared in a lab to potentially fight cancer.…

This early-stage study is testing the safety and best dose of a new drug, HC-7366, when given alongside an approved kidney cancer drug, belzutifan. It will enroll about 80 adults with advanced kidney cancer that has spread or cannot be removed by surgery. The main goal is to find…

This study is testing if a combined PET/MRI scan can better tell the difference between aggressive kidney tumors that need treatment and harmless or slow-growing ones that may not. Participants are adults with a suspicious kidney mass who are already scheduled for a standard MRI.…

This study is testing three new types of PET scans to see if they can better detect and assess kidney cancer. Researchers will use these scans on people suspected of having kidney cancer and on healthy volunteers. The goal is to see if these new scans can provide clearer pictures…

This study is testing if a special type of ultrasound scan can better detect if kidney cancer has come back after a heat or cold treatment. It will compare this new scan to standard MRI or CT scans in 210 patients. The goal is to see if the new method is more accurate at finding …

This study is testing whether cancer patients prefer to receive their standard drug treatments at home instead of in a clinic. Researchers want to see if home-based care reduces the burden of travel and improves treatment satisfaction and quality of life for patients. A specializ…

This study asks cancer patients which way they prefer to receive their immunotherapy drugs: as a quick injection under the skin or through a longer IV infusion. Researchers will enroll 480 people with various advanced cancers to compare comfort, convenience, and quality of life b…

This study aims to understand how kidney and bladder cancers use different nutrients from the blood to grow and survive. Researchers will study tissue samples from 600 patients who are already scheduled for surgery or biopsy for their cancer. By tracking specially labeled nutrien…

This study is testing a new type of PET/CT scan to see if it can accurately detect a specific protein (HIF2α) inside kidney cancer tumors. It is for research only and will not treat the cancer. The goal is to see if the scan results match what is found in actual tumor tissue samp…

This study is testing a new type of blood test to see if it can detect the return of kidney cancer earlier than current standard scans. It will follow 450 patients who are having surgery for newly diagnosed kidney cancer. Researchers will track changes in genetic markers in the b…

This study is testing a new type of PET scan to see if it can help doctors understand kidney cancer better. It involves injecting a small amount of a radioactive tracer attached to an immunotherapy drug and then taking pictures with a PET/CT scanner. The goal is to see if this sc…

This study aims to better understand how inherited changes in the BAP1 gene increase the risk for several types of cancer, including eye and skin melanoma, kidney cancer, and mesothelioma. Researchers will enroll 500 participants who have a personal or strong family history of th…

This study aims to learn more about inherited kidney and urinary tract cancers by observing families who have them. Researchers will collect health information and genetic samples from up to 5,000 participants over time. The goal is to understand how these diseases develop, how t…

This study is a national registry that will follow nearly 2,000 patients in Germany with advanced kidney or bladder cancer. Its purpose is to document the real-world treatments patients receive, track how the disease progresses, and measure patients' quality of life over time. Th…