Immunotherapy duo tested before kidney surgery in small pilot trial

NCT ID NCT06699602

Recruiting now Disease control Sponsor: Memorial Sloan Kettering Cancer Center Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This pilot study is testing whether giving two immunotherapy drugs, cemiplimab and fianlimab, before kidney cancer surgery is safe and practical. Ten people with locally advanced clear cell renal cell carcinoma will receive the drugs before their planned nephrectomy. The main goals are to see if the treatment delays surgery and whether it shrinks the tumor.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: cemiplimab and fianlimab (immunotherapy drugs)
What this could lead to: If it works, this could point toward a new way to shrink kidney tumors before surgery, potentially improving outcomes.
What could go wrong: This is a very small, early-phase pilot study with only 10 people. It may not show clear benefit, and immunotherapy can cause side effects like inflammation.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

nonpapillary renal cell carcinoma renal cell carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

RENAL CELL CARCINOMA

Contacts and locations

Locations

Memorial Sloan Kettering Basking Ridge (Limited Protocol Activites)
RECRUITING

Basking Ridge, New Jersey, 07920, United States
Memorial Sloan Kettering Bergen (Limited Protocol Activities)
RECRUITING

Montvale, New Jersey, 07645, United States
Memorial Sloan Kettering Cancer Center (All Protocol Activites)
RECRUITING

New York, New York, 10065, United States
Memorial Sloan Kettering Cancer Center Suffolk - Commack (Limited Protocol Activities)
RECRUITING

Commack, New York, 11725, United States
Memorial Sloan Kettering Monmouth (Limited Protocol Activities)
RECRUITING

Middletown, New Jersey, 07748, United States
Memorial Sloan Kettering Nassau (Limited Protocol Activities)
RECRUITING

Uniondale, New York, 11553, United States
Memorial Sloan Kettering West Harrison (Limited Protocol Activities)
RECRUITING

Harrison, New York, 10604, United States

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