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New drug cocktail targets Hard-to-Treat cancers

NCT ID NCT05584670

Recruiting now Disease control Sponsor: Sanofi Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This early-stage trial tests an experimental drug called SAR445877, alone or with other cancer drugs, in adults with advanced solid tumors that have spread or cannot be removed. The study has two parts: first, finding a safe dose, and second, checking if the drug shrinks tumors. About 542 people will take part.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
SAR445877 (an experimental drug given by infusion)
What this could lead to
If successful, this could point toward a new treatment option for people with advanced solid tumors that have not responded to other therapies.
What could go wrong
This is an early phase 1/2 trial, so the drug may not be effective or safe in larger studies. Side effects are unknown, and the trial is still recruiting.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

colorectal cancer esophageal squamous cell carcinoma gastric cancer gastroesophageal junction adenocarcinoma hepatocellular carcinoma malignant pleural mesothelioma melanoma neoplasm non-small cell lung carcinoma renal cell carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

SOLID TUMOR

Contacts and locations

Study contacts

  • Contact

    Email: •••••@•••••

Locations

  • BIOCINETIC Ltda_Investigational Site Number : 1520008

    RECRUITING

    Santiago, Reg Metropolitana de Santiago, 8331143, Chile

  • Centro de Investigacion Clinica Bradford Hill_Investigational Site Number : 1520004

    RECRUITING

    Santiago, Reg Metropolitana de Santiago, 8420383, Chile

  • Christiana Care Health System - Newark- Site Number : 8400011

    RECRUITING

    Newark, Delaware, 19718, United States

  • Erasmus MC_Investigational Site Number : 5280003

    RECRUITING

    Rotterdam, South Holland, 3015 CE, Netherlands

  • Fred Hutchinson Cancer Center- Site Number : 8400010

    RECRUITING

    Seattle, Washington, 98109, United States

  • Fundacion Arturo Lopez Perez (FALP) - Providencia - Jose Manuel Infante 805_Investigational Site Number : 1520007

    RECRUITING

    Providencia, 7500000, Chile

  • Hadassah Medical Center - PPDS_Investigational Site Number : 3760005

    RECRUITING

    Jerusalem, Jerusalem, 9112001, Israel

  • Het Nederlands Kanker Instituut Antoni Van Leeuwenhoek Ziekenhuis_Investigational Site Number : 5280001

    RECRUITING

    Amsterdam, North Holland, 1066 CX, Netherlands

  • Instituto de Investigacion Oncologica Vall d'Hebron (VHIO) - EPON_Investigational Site Number : 7240007

    RECRUITING

    Barcelona, Barcelona [Barcelona], 08035, Spain

  • Investigational Site Number : 3920001

    ACTIVE_NOT_RECRUITING

    Kashiwa, Chiba, 277-8577, Japan

  • John Theurer Cancer Center- Site Number : 8400001

    RECRUITING

    Hackensack, New Jersey, 07601, United States

  • Karmanos Cancer Institute - Detroit- Site Number : 8400006

    RECRUITING

    Detroit, Michigan, 48201, United States

  • NYU Langone Medical Center- Site Number : 8400013

    RECRUITING

    New York, New York, 10016, United States

  • Rhode Island Hospital - Providence - Eddy Street- Site Number : 8400004

    RECRUITING

    Providence, Rhode Island, 02905, United States

  • START MADRID_Hospital Universitario HM Sanchinarro - CIOCC_Investigational Site Number : 7240005

    RECRUITING

    Madrid, 28050, Spain

  • Servicios Médicos URUMED SpA_Investigational Site Number : 1520002

    RECRUITING

    Rancagua, General Bernardo O'Higgins, 2852424, Chile

  • Shamir Medical Center_Investigational Site Number : 3760004

    RECRUITING

    Tzrifin, 7033001, Israel

  • Sheba Medical Center - PPDS_Investigational Site Number : 3760003

    RECRUITING

    Ramat Gan, 5262100, Israel

  • Tel Aviv Sourasky Medical Center Ichilov - PPDS_Investigational Site Number : 3760001

    RECRUITING

    Tel Aviv, 6423906, Israel

  • The University of Kansas Cancer Center - Westwood- Site Number : 8400008

    RECRUITING

    Westwood, Kansas, 66205, United States

  • The University of Texas MD Anderson Cancer Center- Site Number : 8400005

    RECRUITING

    Houston, Texas, 77030, United States

  • University of Iowa- Site Number : 8400014

    RECRUITING

    Iowa City, Iowa, 52242, United States

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