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New hope for kidney cancer patients whose tumors return after immunotherapy

NCT ID NCT07049926

Recruiting now Disease control Sponsor: Merck Sharp & Dohme LLC Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 17, 2026 · Updated 3 times

Summary

This study tests experimental drug combinations for people with advanced kidney cancer (clear cell type) that came back during or within 2 years of finishing immunotherapy. About 140 participants will receive these combinations to see if they are safe and can shrink tumors. The goal is to control the disease, not cure it, as ongoing treatment is expected.

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Conditions

The condition(s) this trial relates to.

nonpapillary renal cell carcinoma renal cell carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

RENAL CELL CARCINOMA

Contacts and locations

Study contacts

  • Contact

    Email: •••••@•••••

Locations

  • Asan Medical Center ( Site 5800)

    RECRUITING

    Seoul, 05505, South Korea

  • Bradfordhill ( Site 6101)

    RECRUITING

    Santiago, Region M. de Santiago, 8420383, Chile

  • C.H.U. de Strasbourg Hopital de Hautepierre ( Site 5203)

    RECRUITING

    Strasbourg, Bas-Rhin, 67098, France

  • Centre Eugene Marquis ( Site 5205)

    RECRUITING

    Rennes, Ille-et-Vilaine, 35042, France

  • Centro de Estudios Clínicos SAGA ( Site 6110)

    RECRUITING

    Santiago, Region M. de Santiago, 7500653, Chile

  • Centrum Onkologii im. Prof. Franciszka Lukaszczyka-Ambulatorium Chemioterapii ( Site 6201)

    RECRUITING

    Bydgoszcz, Kuyavian-Pomeranian Voivodeship, 85-796, Poland

  • Duke Cancer Institute ( Site 5015)

    RECRUITING

    Durham, North Carolina, 27710, United States

  • Gustave Roussy ( Site 5202)

    RECRUITING

    Villejuif, Île-de-France Region, 94805, France

  • Hospital Universitari Vall d'Hebron ( Site 5300)

    RECRUITING

    Barcelona, 08035, Spain

  • Hospital Universitario Ramon y Cajal ( Site 5301)

    RECRUITING

    Madrid, Madrid, Comunidad de, 28034, Spain

  • Institut Claudius Regaud ( Site 5200)

    RECRUITING

    Toulouse, Haute-Garonne, 31059, France

  • Institut De Cancerologie De Lorraine ( Site 5204)

    RECRUITING

    Vandœuvre-lès-Nancy, Meurthe-et-Moselle, 54513, France

  • Laura and Isaac Perlmutter Cancer Center ( Site 5016)

    RECRUITING

    New York, New York, 10016, United States

  • Memorial Sloan Kettering Cancer Center ( Site 5002)

    RECRUITING

    New York, New York, 10065, United States

  • Perlmutter Cancer Center at NYU Langone Hospital - Long Island ( Site 5026)

    RECRUITING

    Mineola, New York, 11501, United States

  • Rabin Medical Center ( Site 5502)

    RECRUITING

    Petah Tikva, 4941492, Israel

  • Rambam Health Care Campus ( Site 5500)

    RECRUITING

    Haifa, 3109601, Israel

  • Samsung Medical Center ( Site 5801)

    RECRUITING

    Seoul, 06351, South Korea

  • Severance Hospital ( Site 5802)

    RECRUITING

    Seoul, 03722, South Korea

  • Sheba Medical Center ( Site 5501)

    RECRUITING

    Ramat Gan, 5265601, Israel

  • Sourasky Medical Center ( Site 5503)

    RECRUITING

    Tel Aviv, 6423906, Israel

  • St Bartholomew's Hospital ( Site 5401)

    RECRUITING

    London, London, City of, EC1A7BE, United Kingdom

  • The Beatson West of Scotland Cancer Centre ( Site 5405)

    RECRUITING

    Glasgow, Glasgow City, G12 0YN, United Kingdom

  • The Christie NHS Foundation Trust ( Site 5400)

    RECRUITING

    Manchester, M20 4BX, United Kingdom

  • UCSF Medical Center at Mission Bay ( Site 5008)

    RECRUITING

    San Francisco, California, 94158, United States

  • UPMC Cancer Center/Hillman Cancer Center ( Site 5017)

    RECRUITING

    Pittsburgh, Pennsylvania, 15232, United States

  • Uniwersyteckie Centrum Kliniczne ( Site 6202)

    RECRUITING

    Gdansk, Pomeranian Voivodeship, 80-214, Poland

  • Vanderbilt University Medical Center ( Site 5004)

    RECRUITING

    Nashville, Tennessee, 37232, United States

  • Velindre Cancer Centre ( Site 5407)

    RECRUITING

    Cardiff, CF14 2TL, United Kingdom

  • Western General Hospital ( Site 5402)

    RECRUITING

    Edinburgh, Edinburgh, City of, EH42XU, United Kingdom

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