New drug YL205 aims to shrink advanced tumors in early trial
NCT ID NCT06459973
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tests an experimental drug, YL205, in 252 people with advanced solid tumors that have spread or cannot be removed by surgery. The drug is given by IV every three weeks. The main goals are to check safety, find the right dose, and see if it helps shrink tumors. This is an early-stage trial, so the main focus is on safety and dosing, not yet on proving it works.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- YL205 (an experimental drug given by IV infusion every 3 weeks)
- What this could lead to
- If successful, this could point toward a new treatment option for people with advanced solid tumors that have not responded to other therapies.
- What could go wrong
- This is an early-phase trial (Phase I/II) with a small number of participants, so the drug may not prove effective or may have unexpected side effects. It is also only being tested in China, so results may not apply to all populations.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Anyang Cancer Hospital
RECRUITINGAnyang, Henan, China
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Central Hospital Affiliated to Shandong First Medical University
RECRUITINGJinan, Shandong, China
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Chinese People's Liberation Army Army Characterstic Medical Center
RECRUITINGChongqing, China
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Chongqing Cancer Hospital
RECRUITINGChongqing, China
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Comprehensive Cancer Centers of Nevada (CCCN) - Central Valley
RECRUITINGLas Vegas, Nevada, 89169, United States
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Florida Cancer Specialists - Lake Mary
RECRUITINGLake Mary, Florida, 32746, United States
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Fujian Provincial Cancer Hospital
RECRUITINGFuzhou, Fujian, China
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Guangxi Medical University Cancer Hospital
RECRUITINGNanning, Guangxi, China
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Hainan General Hospital
RECRUITINGHaikou, Hainan, China
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Harbin Medical University Cancer Hospital
RECRUITINGHarbin, Heilongjiang, China
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Henan Cancer Hospital
RECRUITINGZhengzhou, Henan, China
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Hubei Cancer Hospital
RECRUITINGWuhan, Hubei, China
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Hunan Provincial Cancer Hospital
RECRUITINGChangsha, Hunan, China
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Jilin Provincial Cancer Hospital
RECRUITINGChangchun, Jilin, China
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Jingzhou First People's Hospital
RECRUITINGJingzhou, Hubei, China
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Liaoning Cancer Hospital
RECRUITINGShenyang, Liaoning, China
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Linyi Cancer Hospital
RECRUITINGLinyi, Shandong, China
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Norton Cancer Institute
RECRUITINGLouisville, Kentucky, 40241, United States
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Obstetrics & Gynecology Hospital of Fudan University
RECRUITINGShanghai, China
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Peking Union Medical College Hospital
RECRUITINGBeijing, China
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Providence Cancer Institute - Franz Clinic
RECRUITINGPortland, Oregon, 97213, United States
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Qilu Hospital of Shandong University
RECRUITINGJinan, Shandong, China
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Sarah Cannon Research (SCRI)-Tennessee
RECRUITINGNashville, Texas, 37203, United States
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Sarah Cannon Research Institute (SCRI)- Denver
RECRUITINGDenver, Colorado, 80218, United States
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Shandong Cancer Hospital
RECRUITINGJinan, Shandong, China
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Shanxi Cancer Hospital
RECRUITINGTaiyuan, Shanxi, China
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Southwest Women's Oncology
RECRUITINGAlbuquerque, New Mexico, 87109, United States
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Stephenson Cancer Center (Oklahoma)
RECRUITINGOklahoma City, Oklahoma, 73104, United States
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Sun Yat-Sen Memorial Hospital,Sun Yat-Sen University
RECRUITINGGuangzhou, Guangdong, China
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The First Affiliated Hospital of XI'AN Jiaotong University
RECRUITINGXi’an, Shanxi, China
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The First Affiliated Hospital. Zhejiang University School of Medicine
RECRUITINGHangzhou, Zhejiang, China
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The Fourth Hospital of Hebei Medical University
RECRUITINGShijiazhuang, Hebei, China
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The People's Hospital of Liaoning Province
RECRUITINGShenyang, Liaoning, China
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The Southwest Hospital of AMU
RECRUITINGChongqing, China
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Tongji Medical College of Hust TongJi Hospital
RECRUITINGWuhan, Hubei, China
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Union hospital Tongji Medical Colllege Huazhong University of School and Technology
RECRUITINGWuhan, Hubei, China
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University of Washington
RECRUITINGSeattle, Washington, 98915, United States
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Washington University School of Medicine - Center for advanced Medicine
RECRUITINGSt Louis, Missouri, 63110, United States
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West China Second University Hospital, Sichuan University
RECRUITINGChengdu, Sichuan, China
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Xiangya Hospital of Central South University
RECRUITINGChangsha, Hunan, China
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Yale Cancer Center
RECRUITINGNew Haven, Connecticut, 06510, United States
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Yunnan Cancer Hospital
RECRUITINGKunming, Yunnan, China
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Zhongnan Hospital of Wuhan University
RECRUITINGWuhan, Hubei, China
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