RENAL CELL CARCINOMA

This study tested whether adding an immunotherapy drug (nivolumab) to a targeted therapy (tivozanib) helps people with advanced kidney cancer whose disease worsened after prior treatment, including immunotherapy. The trial enrolled 343 adults and compared the combination against …

This study tested a new type of vaccine made by mixing a patient's own tumor cells with immune cells from a healthy donor. The goal was to see if these 'fusion cell' injections are safe and can help the immune system attack advanced kidney cancer. The trial involved 40 adults wit…

This study tested whether the immunotherapy drug pembrolizumab (Keytruda) can help prevent kidney cancer from coming back after surgery to remove the kidney. Nearly 1,000 adults with intermediate-to-high risk of recurrence received either pembrolizumab or a placebo every three we…

This early-phase study tested a combination of two experimental drugs (vobramitamab duocarmazine and lorigerlimab) in 31 people with advanced solid tumors like prostate, melanoma, and pancreatic cancer. The main goal was to check safety and find the right dose. Participants recei…

This study tested whether transferring gut bacteria from people who responded well to immunotherapy could help others with advanced kidney cancer. 50 participants received either a fecal transplant or a placebo alongside their standard immunotherapy. The goal was to see if this a…

This study tested a combination of two drugs, pembrolizumab and lenvatinib, in 160 people with a rare type of advanced kidney cancer (non-clear cell renal cell carcinoma) that had not been treated before. The goal was to see if the drugs could shrink tumors. The treatment helped …

This early-phase study tested a drug called gevokizumab alongside standard cancer treatments in 167 adults with advanced colorectal, stomach, or kidney cancer. The goal was to find a safe dose and see if the combination helps control tumor growth. While not a cure, it aims to imp…

This study tested a new type of stem cell transplant for children and young adults (ages 2-21) with cancers that came back or didn't respond to treatment. The approach uses a special cell filter to speed up immune recovery after transplant. The main goal was to see if the procedu…

This study tested a combination of two drugs (pembrolizumab and axitinib) against the standard single drug (sunitinib) in 861 people with advanced kidney cancer that had spread. The goal was to see if the combo could help people live longer and keep the cancer from growing. Resul…

This study observed 100 older adults (age 70+) with advanced kidney cancer to see how safe and effective the drug Cabozantinib is. The main goal was to track side effects. The study was completed, but it was observational, meaning it just watched what happened without giving a ne…

This study tested a fast-recovery program for people having minimally invasive kidney surgery (laparoscopic or robotic) to remove part or all of a kidney due to early-stage cancer. The goal was to see if the program could shorten hospital stays by at least one day without increas…

This study looked at whether people with advanced cancers (melanoma, kidney, or lung cancer) receiving first-line immunotherapy can successfully collect small blood samples at home using a finger-prick method. 24 patients participated, and the goal was to see if home testing is p…

This study looked at 91 adults with advanced kidney cancer to see if tiny particles in blood and urine (called exosomal miRNAs) can predict how well treatment works. Patients were treated with standard therapies like immune checkpoint inhibitors or targeted drugs. Researchers col…

This study looked at how immune checkpoint inhibitors, a type of cancer drug, might harm blood vessels and speed up artery disease. Researchers followed 39 cancer patients before and after starting these drugs, using ultrasound and blood tests to track changes. The goal was to be…

This study tested whether taking the kidney cancer drug cabozantinib with a light breakfast changes how much drug gets into the body. Twelve patients with advanced kidney cancer took the drug both with and without breakfast to compare drug levels. The goal is to find a dosing sch…

This study looked at whether it's possible to use a child's tumor DNA to choose their next treatment. 186 children with cancers that came back or didn't respond to standard therapy had their tumors analyzed. The goal was to see if this approach could be done quickly enough to gui…

This study looked at whether tiny particles called exosomes, found in blood and urine, can help predict how well advanced kidney cancer responds to treatment. Researchers followed 91 patients receiving standard therapies and collected samples over 16 weeks. The goal was to find p…