New combo therapy shows promise for Tough-to-Treat kidney cancer
NCT ID NCT04987203
First seen May 10, 2026 · Last updated May 16, 2026 · Updated 2 times
Summary
This study tested whether adding an immunotherapy drug (nivolumab) to a targeted therapy (tivozanib) helps people with advanced kidney cancer whose disease worsened after prior treatment, including immunotherapy. The trial enrolled 343 adults and compared the combination against tivozanib alone. The main goal was to see if the combo could delay cancer growth or death.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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ACEREY Centro de Investigación Clínica Oncológica
Viña del Mar, Valparaiso, 2520612, Chile
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AO S.Camillo-Forlanini
Roma, Roma, 00152, Italy
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AOUC Azienda Ospedaliero-Universitaria Careggi
Florence, 50134, Italy
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AZ Groeninge - Campus Kennedylaan
Kortrijk, 8500, Belgium
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Addenbrooke's Hospital - Oncology
Cambridge, Cambridgeshire, CB2 0QQ, United Kingdom
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Allegheny General Hospital (AGH)
Pittsburgh, Pennsylvania, 15212-4756, United States
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Azienda Mater Domini
Catanzaro, Catanzaro, 88100, Italy
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Azienda Ospedaliera Santa Maria di Terni
Terni, Terni, 05100, Italy
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BC Cancer - Vancouver Centre
Vancouver, British Columbia, V5Z 4E6, Canada
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C.H.U. de Orense
Ourense, 32005, Spain
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CHD Vendee La Roche sur Yon - Gastro-Entérologie
La Roche-sur-Yon, 85925, France
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CHU Brugmann - Victor Horta
Brussels, 1020, Belgium
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CHU Michallon - Hopital Nord - Cancérologie Et Hématologie
Grenoble, Isère, 38043, France
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COPERNICUS Podmiot Leczn. Sp z o.o.,Wojew. Centrum Onkologii
Gdansk, Pomeranian Voivodeship, 80-219, Poland
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Centralny Szpital Kliniczny Ministerstwa Spraw Wewnetrznych
Warsaw, 02-507, Poland
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Centre Hospitalier de Poitiers
Poitiers, Poitou-Charentes, 86021, France
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Centre Leon Berard - departement d'oncologie medicale
Lyon, Rhône, 69373, France
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Centre de Lutte Contre le Cancer (CLCC)
Nice, 06189, France
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Centre de Lutte Contre le Cancer (CLCC) - Gustave Roussy (Institut de Cancerologie Gustave-Roussy)
Villejuif, Île-de-France Region, 94805, France
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Centro Gaucho Integrado de Onc
Porto Alegre, Rio Grande do Sul, 90110-270, Brazil
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Centro Oncologico de Rosario
Rosario, Santa Fe Province, S2000KZE, Argentina
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Centro Oncológico Korben
Buenos Aires, Ciudad Autónoma de Buenos Aire, C1280AEB, Argentina
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Centro de Estudios Clinicos In
Santiago, Región Metropolitana de Santia, 8420383, Chile
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Centro de Estudios Clínicos SAGA SpA
Santiago, Región Metropolitana de Santia, Chile
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Centro para la Atención Integral del paciente Oncológico
San Miguel de Tucumán, Tucumán Province, T4000GTB, Argentina
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Chao Family Comprehensive Cancer Center, UC Irvine
Irvine, California, 92868, United States
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Chattanooga Oncology and Hematology Associates
Chattanooga, Tennessee, 37404, United States
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City of Hope Comprehensive Cancer Center
Duarte, California, 91010, United States
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Cleveland Clinic
Cleveland, Ohio, 44195-0001, United States
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Clinica de Neoplasias Litoral
Itajaí, Santa Catarina, 88301-220, Brazil
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Clinique Victor Hugo - Hematologie
Le Mans, Sarthe, 72000, France
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Clínica Viedma
Viedma, Río Negro Province, R8500JYJ, Argentina
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Dana-Farber Cancer Institute - Medicine
Boston, Massachusetts, 02215, United States
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European Institute of Oncology
Milan, Milano, 20141, Italy
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Europejskie Centrum Zdrowia Otwock, Szpital im. F. Chopina
Otwock, Masovian Voivodeship, 05-400, Poland
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FN Hradec Kralove
Hradec Králové, 500 05, Czechia
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FN Kralovske Vinohrady
Prague, 100 34, Czechia
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Fakultni Thomayerova nemocnice
Prague, Praha 4, 140 59, Czechia
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Florida Cancer Specialists & Res Inst
Fort Myers, Florida, 33901, United States
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Florida Cancer Specialists & Research Institute (FCS) - Tampa Cancer Center Location
St. Petersburg, Florida, 33705, United States
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Fondazione Policlinico Universitario Agostino Gemelli
Roma, Roma, '00168, Italy
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Fundación Instituto Valenciano
Valencia, Valencia, 46009, Spain
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H. Prof. Doutor Fernando Fonseca
Amadora, Lisbon District, 2720-276, Portugal
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H. Santo Antonio. Centro Hospitalar do Porto
Porto, Porto District, 4099-001, Portugal
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H. de Santa Maria. Centro Hospitalar Lisboa Norte - Oncologia
Lisbon, Lisbon District, 1649-035, Portugal
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H.G.U. de Elche
Elche, Alicante, 03203, Spain
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Henry Ford Hospital
Detroit, Michigan, 48202, United States
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Hopital Foch
Suresnes, Hauts-de-Seine, 92151, France
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Hopital Saint-Andre - Service d'Oncologie Medicale
Bordeaux, Gironde, 33075, France
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Hopital Trousseau - medical oncology
Tours, 37044, France
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Hospices Civils de Lyon (HCL) - Centre Hospitalier Lyon-Sud
Pierre-Bénite, Auvergne-Rhône-Alpes, 69495, France
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Hospital Clínico San Carlos
Madrid, Madrid, 28040, Spain
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Hospital Del Mar
Barcelona, Barcelona, 8003, Spain
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Hospital Nossa Senhora da Conc
Porto Alegre, 90610-000, Brazil
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Hospital Particular do Algarve - Gambelas-Faro
Faro, Faro District, 8005-226, Portugal
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Hospital U. 12 Octubre
Madrid, Madrid, 28041, Spain
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Hospital Universitari Parc Tau
Sabadell, Barcelona, 8208, Spain
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Hospital Universitario La Paz
Madrid, Madrid, 28046, Spain
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Hospital Universitario Ramón y Cajal
Madrid, Madrid, 28034, Spain
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Hospital Universitario Son Espases
Palma de Mallorca, Balearic Islands, 07010, Spain
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Hospital Universitario Vall d'
Barcelona, Barcelona, 08035, Spain
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Hospital Universitario Virgen
Seville, Sevilla, 41009, Spain
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Hospital Universitario Y Politécnico La Fe
Valencia, Valenciana, Comunidad, 46026, Spain
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Hospital de La Santa Creu i Sant Pau
Barcelona, Barcelona, 08025, Spain
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Hôpital privé Le Bois
Lille, Nord, 59000, France
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ICO - Site Rene Gauducheau - Oncologie Medicale
Saint-Herblain, 44805, France
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ICO-Hospital Universitari de G
Girona, Girona, 17007, Spain
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IRCCS Fondazione "Giovanni Pas
Naples, 80131, Italy
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IRCCS Policlinico San Matteo
Pavia, Pavia, 27100, Italy
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IRST
Meldola (Fc), Forli, 47014, Italy
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Imperial College Healthcare NHS Trust - Hammersmith Hospital
London, London, City of, W6 8RF, United Kingdom
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Institut Catalá d´Oncología (I.C.O.)
Barcelona, Barcelona, 08908, Spain
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Institut Jules Bordet - Oncologie Médicale
Anderlecht, Brussels Capital, 1070, Belgium
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Institut Paoli Calmettes - Hôpital de jour
Marseille, Bouches-du-Rhône, 13273, France
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Institut de Cancérologie de Lorraine
Vandœuvre-lès-Nancy, 54511, France
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Institut de cancérologie de Strasbourg Europe - ICANS
Strasbourg, Alsace, 67200, France
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Instituto Brasileiro de Controle do Cancer - ibcc
São Paulo, São Paulo, 03102-002, Brazil
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Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán
Tlalpan, 14080, Mexico
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Instituto Português Oncologia Francisco Gentil do Porto
Porto, 4200-072, Portugal
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Jessa Ziekenhuis - Campus Virga Jesse - Medische Oncologie
Hasselt, Limburg, 3500, Belgium
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John Hopkins Medicine - Hematology/oncology
Baltimore, Maryland, 21287, United States
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Kaiser Permanente Riverside Medical Center
Riverside, California, 92505, United States
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Leeds Teaching Hospitals NHS Trust
Leeds, LS9 7TF, United Kingdom
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Lehigh Valley Physician Group
Allentown, Pennsylvania, 18103-6218, United States
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Leland Stanford Junior University
Redwood City, California, 94063, United States
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Liverpool Hospital Cancer Therapy Centre
Liverpool, New South Wales, 2170, Australia
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Maryland Oncology Hematology
Clinton, Maryland, 20735, United States
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Mater Misericordiae Limited
Brisbane, Queensland, 4101, Australia
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Meditek Ltda.
Santiago, Santiago Metropolitan, 8420383, Chile
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Medizinische Hochschule Hannover
Hanover, Lower Saxony, 30625, Germany
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Memorial Sloan Kettering Cancer Center (MSKCC) - Memorial Hospital
New York, New York, 10065, United States
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Memorial Sloan Kettering Cancer Center - Monmouth - Oncology
Middletown, New Jersey, 07748-3052, United States
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Memorial Sloan Kettering Cancer Center - Nassau
Uniondale, New York, 11553, United States
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Memorial Sloan Kettering Cancer Center - Westchester
East White Plains, New York, 10604, United States
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Mount Vernon Cancer Centre
Northwood, England, HA6 2JW, United Kingdom
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Narodowy Instytut Onkologii im. Marii Skłodowskiej-Curie - Państwowy Instytut Badawczy
Warsaw, 02-781, Poland
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New Cross Hospital
Wolverhampton, Wolverhampton, WV10 0QP, United Kingdom
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Northwest Medical Specialties PLLC
Tacoma, Washington, 98405-5016, United States
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Nzoz Mrukmed Lekarz Beata Madej-Mruk I Partner Sp. P.
Rzeszów, Podkarpackie Voivodeship, 35-021, Poland
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Oncology Hematology West PC dba Nebraska Cancer Specialists
Omaha, Nebraska, 68130, United States
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Ospedale S.Donato, AUSL 8 di Arezzo
Arezzo, Arezzo, 52100, Italy
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P.O. Ss. Annunziata
Chieti Scalo, Chieti, 66013, Italy
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PO di Cremona, ASST di Cremona - Oncologia medica
Cremona, Italy
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Pontificia Universidade
Porto Alegre, 90610-000, Brazil
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Princess Alexandra Hospital
Woolloongabba, Queensland, 4102, Australia
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Roswell - Roswell Park Cancer Institute - Medical Oncology
Buffalo, New York, 14263, United States
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Royal Blackburn Hospital - Oncology
Preston, Lancashire, PR2 9HT, United Kingdom
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Royal Derby Hospital
Derby, DE22 3NE, United Kingdom
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Royal Marsden - Sutton
Sutton, Surrey, SM2 5PT, United Kingdom
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Royal Marsden Hospital
Sutton, Surrey, SM2 5PT, United Kingdom
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St. Vincent Frontier Cancer Center
Billings, Montana, 59102-6746, United States
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Sunnybrook Research Institute, sunnybrook Health Sciences Ct
Toronto, Ontario, M4N 3M5, Canada
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Sunshine Hospital
Geelong, Victoria, 3220, Australia
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Szpital Kliniczny Przemienienia Panskiego UM w Poznaniu
Poznan, Greater Poland Voivodeship, 60-569, Poland
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Szpital Specjalist. w Brzozowie,Podkarpacki Ośrodek Onkologi
Brzozów, Podkarpackie Voivodeship, 36-200, Poland
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Szpital Specjalistyczny im. L. Rydygiera w Krakowie
Krakow, Lesser Poland Voivodeship, 31-826, Poland
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Tennessee Oncology, PLLC
Nashville, Tennessee, 37203, United States
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Texas Oncology - Baylor Charles A. Sammons Cancer Center
Dallas, Texas, 75246, United States
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Texas Oncology - Central Austin Cancer Center
Austin, Texas, 78731, United States
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The Christie NHS Foundation Trust - Medical Oncology
Manchester, Manchester, M20 4BX, United Kingdom
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The University of Kansas Cancer Center
Westwood, Kansas, 66205-2005, United States
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Tom Baker Cancer Centre
Calgary, Alberta, T2N 4N2, Canada
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Tulane Cancer Center Clinic - Oncology
New Orleans, Louisiana, 70112, United States
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UH Cleveland Medical Center
Columbia, South Carolina, 29210, United States
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US Oncology - Rocky Mountain Cancer Centers - Midtown
Denver, Colorado, 80218-1237, United States
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US Oncology Texas Oncology (CCC of South Texas) - San Antonio Medical Center
San Antonio, Texas, 78240, United States
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UZ Gent - Medische Oncologie
Ghent, Oost-Vlaanderen, 9000, Belgium
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Universidade Estadual de Campi
Campinas, São Paulo, 13083-970, Brazil
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University Health Network - Princess Margaret Cancer Centre
Toronto, Ontario, M5G 2M9, Canada
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University Hospital Brno
Brno, Brno-město, 625 00, Czechia
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University Of Washington - Medical Center
Seattle, Washington, 98109, United States
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University of California San Diego
La Jolla, California, 92037, United States
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University of Kentucky UK Markey Cancer Center
Lexington, Kentucky, 40536, United States
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University of Maryland Medical Center-Greenebaum Cancer Ctr
Baltimore, Maryland, 21201, United States
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University of New Mexico - Comprehensive Cancer Center
Albuquerque, New Mexico, 87131-0001, United States
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Universitätsklinikum Heidelberg
Heidelberg, Baden-Wurttemberg, 69120, Germany
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Vanderbilt-Ingram Cancer Center
Nashville, Tennessee, 37232, United States
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Wojewodzki Szpital Specjalistyczny
Biała Podlaska, 21-500, Poland
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ZNA Jan Palfijn
Merksen, Antwerpen, 2170, Belgium
Conditions
Explore the condition pages connected to this study.