New combo therapy shows promise for Tough-to-Treat kidney cancer

NCT ID NCT04987203

First seen May 10, 2026 · Last updated May 16, 2026 · Updated 2 times

Summary

This study tested whether adding an immunotherapy drug (nivolumab) to a targeted therapy (tivozanib) helps people with advanced kidney cancer whose disease worsened after prior treatment, including immunotherapy. The trial enrolled 343 adults and compared the combination against tivozanib alone. The main goal was to see if the combo could delay cancer growth or death.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Locations

  • ACEREY Centro de Investigación Clínica Oncológica

    Viña del Mar, Valparaiso, 2520612, Chile

  • AO S.Camillo-Forlanini

    Roma, Roma, 00152, Italy

  • AOUC Azienda Ospedaliero-Universitaria Careggi

    Florence, 50134, Italy

  • AZ Groeninge - Campus Kennedylaan

    Kortrijk, 8500, Belgium

  • Addenbrooke's Hospital - Oncology

    Cambridge, Cambridgeshire, CB2 0QQ, United Kingdom

  • Allegheny General Hospital (AGH)

    Pittsburgh, Pennsylvania, 15212-4756, United States

  • Azienda Mater Domini

    Catanzaro, Catanzaro, 88100, Italy

  • Azienda Ospedaliera Santa Maria di Terni

    Terni, Terni, 05100, Italy

  • BC Cancer - Vancouver Centre

    Vancouver, British Columbia, V5Z 4E6, Canada

  • C.H.U. de Orense

    Ourense, 32005, Spain

  • CHD Vendee La Roche sur Yon - Gastro-Entérologie

    La Roche-sur-Yon, 85925, France

  • CHU Brugmann - Victor Horta

    Brussels, 1020, Belgium

  • CHU Michallon - Hopital Nord - Cancérologie Et Hématologie

    Grenoble, Isère, 38043, France

  • COPERNICUS Podmiot Leczn. Sp z o.o.,Wojew. Centrum Onkologii

    Gdansk, Pomeranian Voivodeship, 80-219, Poland

  • Centralny Szpital Kliniczny Ministerstwa Spraw Wewnetrznych

    Warsaw, 02-507, Poland

  • Centre Hospitalier de Poitiers

    Poitiers, Poitou-Charentes, 86021, France

  • Centre Leon Berard - departement d'oncologie medicale

    Lyon, Rhône, 69373, France

  • Centre de Lutte Contre le Cancer (CLCC)

    Nice, 06189, France

  • Centre de Lutte Contre le Cancer (CLCC) - Gustave Roussy (Institut de Cancerologie Gustave-Roussy)

    Villejuif, Île-de-France Region, 94805, France

  • Centro Gaucho Integrado de Onc

    Porto Alegre, Rio Grande do Sul, 90110-270, Brazil

  • Centro Oncologico de Rosario

    Rosario, Santa Fe Province, S2000KZE, Argentina

  • Centro Oncológico Korben

    Buenos Aires, Ciudad Autónoma de Buenos Aire, C1280AEB, Argentina

  • Centro de Estudios Clinicos In

    Santiago, Región Metropolitana de Santia, 8420383, Chile

  • Centro de Estudios Clínicos SAGA SpA

    Santiago, Región Metropolitana de Santia, Chile

  • Centro para la Atención Integral del paciente Oncológico

    San Miguel de Tucumán, Tucumán Province, T4000GTB, Argentina

  • Chao Family Comprehensive Cancer Center, UC Irvine

    Irvine, California, 92868, United States

  • Chattanooga Oncology and Hematology Associates

    Chattanooga, Tennessee, 37404, United States

  • City of Hope Comprehensive Cancer Center

    Duarte, California, 91010, United States

  • Cleveland Clinic

    Cleveland, Ohio, 44195-0001, United States

  • Clinica de Neoplasias Litoral

    Itajaí, Santa Catarina, 88301-220, Brazil

  • Clinique Victor Hugo - Hematologie

    Le Mans, Sarthe, 72000, France

  • Clínica Viedma

    Viedma, Río Negro Province, R8500JYJ, Argentina

  • Dana-Farber Cancer Institute - Medicine

    Boston, Massachusetts, 02215, United States

  • European Institute of Oncology

    Milan, Milano, 20141, Italy

  • Europejskie Centrum Zdrowia Otwock, Szpital im. F. Chopina

    Otwock, Masovian Voivodeship, 05-400, Poland

  • FN Hradec Kralove

    Hradec Králové, 500 05, Czechia

  • FN Kralovske Vinohrady

    Prague, 100 34, Czechia

  • Fakultni Thomayerova nemocnice

    Prague, Praha 4, 140 59, Czechia

  • Florida Cancer Specialists & Res Inst

    Fort Myers, Florida, 33901, United States

  • Florida Cancer Specialists & Research Institute (FCS) - Tampa Cancer Center Location

    St. Petersburg, Florida, 33705, United States

  • Fondazione Policlinico Universitario Agostino Gemelli

    Roma, Roma, '00168, Italy

  • Fundación Instituto Valenciano

    Valencia, Valencia, 46009, Spain

  • H. Prof. Doutor Fernando Fonseca

    Amadora, Lisbon District, 2720-276, Portugal

  • H. Santo Antonio. Centro Hospitalar do Porto

    Porto, Porto District, 4099-001, Portugal

  • H. de Santa Maria. Centro Hospitalar Lisboa Norte - Oncologia

    Lisbon, Lisbon District, 1649-035, Portugal

  • H.G.U. de Elche

    Elche, Alicante, 03203, Spain

  • Henry Ford Hospital

    Detroit, Michigan, 48202, United States

  • Hopital Foch

    Suresnes, Hauts-de-Seine, 92151, France

  • Hopital Saint-Andre - Service d'Oncologie Medicale

    Bordeaux, Gironde, 33075, France

  • Hopital Trousseau - medical oncology

    Tours, 37044, France

  • Hospices Civils de Lyon (HCL) - Centre Hospitalier Lyon-Sud

    Pierre-Bénite, Auvergne-Rhône-Alpes, 69495, France

  • Hospital Clínico San Carlos

    Madrid, Madrid, 28040, Spain

  • Hospital Del Mar

    Barcelona, Barcelona, 8003, Spain

  • Hospital Nossa Senhora da Conc

    Porto Alegre, 90610-000, Brazil

  • Hospital Particular do Algarve - Gambelas-Faro

    Faro, Faro District, 8005-226, Portugal

  • Hospital U. 12 Octubre

    Madrid, Madrid, 28041, Spain

  • Hospital Universitari Parc Tau

    Sabadell, Barcelona, 8208, Spain

  • Hospital Universitario La Paz

    Madrid, Madrid, 28046, Spain

  • Hospital Universitario Ramón y Cajal

    Madrid, Madrid, 28034, Spain

  • Hospital Universitario Son Espases

    Palma de Mallorca, Balearic Islands, 07010, Spain

  • Hospital Universitario Vall d'

    Barcelona, Barcelona, 08035, Spain

  • Hospital Universitario Virgen

    Seville, Sevilla, 41009, Spain

  • Hospital Universitario Y Politécnico La Fe

    Valencia, Valenciana, Comunidad, 46026, Spain

  • Hospital de La Santa Creu i Sant Pau

    Barcelona, Barcelona, 08025, Spain

  • Hôpital privé Le Bois

    Lille, Nord, 59000, France

  • ICO - Site Rene Gauducheau - Oncologie Medicale

    Saint-Herblain, 44805, France

  • ICO-Hospital Universitari de G

    Girona, Girona, 17007, Spain

  • IRCCS Fondazione "Giovanni Pas

    Naples, 80131, Italy

  • IRCCS Policlinico San Matteo

    Pavia, Pavia, 27100, Italy

  • IRST

    Meldola (Fc), Forli, 47014, Italy

  • Imperial College Healthcare NHS Trust - Hammersmith Hospital

    London, London, City of, W6 8RF, United Kingdom

  • Institut Catalá d´Oncología (I.C.O.)

    Barcelona, Barcelona, 08908, Spain

  • Institut Jules Bordet - Oncologie Médicale

    Anderlecht, Brussels Capital, 1070, Belgium

  • Institut Paoli Calmettes - Hôpital de jour

    Marseille, Bouches-du-Rhône, 13273, France

  • Institut de Cancérologie de Lorraine

    Vandœuvre-lès-Nancy, 54511, France

  • Institut de cancérologie de Strasbourg Europe - ICANS

    Strasbourg, Alsace, 67200, France

  • Instituto Brasileiro de Controle do Cancer - ibcc

    São Paulo, São Paulo, 03102-002, Brazil

  • Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán

    Tlalpan, 14080, Mexico

  • Instituto Português Oncologia Francisco Gentil do Porto

    Porto, 4200-072, Portugal

  • Jessa Ziekenhuis - Campus Virga Jesse - Medische Oncologie

    Hasselt, Limburg, 3500, Belgium

  • John Hopkins Medicine - Hematology/oncology

    Baltimore, Maryland, 21287, United States

  • Kaiser Permanente Riverside Medical Center

    Riverside, California, 92505, United States

  • Leeds Teaching Hospitals NHS Trust

    Leeds, LS9 7TF, United Kingdom

  • Lehigh Valley Physician Group

    Allentown, Pennsylvania, 18103-6218, United States

  • Leland Stanford Junior University

    Redwood City, California, 94063, United States

  • Liverpool Hospital Cancer Therapy Centre

    Liverpool, New South Wales, 2170, Australia

  • Maryland Oncology Hematology

    Clinton, Maryland, 20735, United States

  • Mater Misericordiae Limited

    Brisbane, Queensland, 4101, Australia

  • Meditek Ltda.

    Santiago, Santiago Metropolitan, 8420383, Chile

  • Medizinische Hochschule Hannover

    Hanover, Lower Saxony, 30625, Germany

  • Memorial Sloan Kettering Cancer Center (MSKCC) - Memorial Hospital

    New York, New York, 10065, United States

  • Memorial Sloan Kettering Cancer Center - Monmouth - Oncology

    Middletown, New Jersey, 07748-3052, United States

  • Memorial Sloan Kettering Cancer Center - Nassau

    Uniondale, New York, 11553, United States

  • Memorial Sloan Kettering Cancer Center - Westchester

    East White Plains, New York, 10604, United States

  • Mount Vernon Cancer Centre

    Northwood, England, HA6 2JW, United Kingdom

  • Narodowy Instytut Onkologii im. Marii Skłodowskiej-Curie - Państwowy Instytut Badawczy

    Warsaw, 02-781, Poland

  • New Cross Hospital

    Wolverhampton, Wolverhampton, WV10 0QP, United Kingdom

  • Northwest Medical Specialties PLLC

    Tacoma, Washington, 98405-5016, United States

  • Nzoz Mrukmed Lekarz Beata Madej-Mruk I Partner Sp. P.

    Rzeszów, Podkarpackie Voivodeship, 35-021, Poland

  • Oncology Hematology West PC dba Nebraska Cancer Specialists

    Omaha, Nebraska, 68130, United States

  • Ospedale S.Donato, AUSL 8 di Arezzo

    Arezzo, Arezzo, 52100, Italy

  • P.O. Ss. Annunziata

    Chieti Scalo, Chieti, 66013, Italy

  • PO di Cremona, ASST di Cremona - Oncologia medica

    Cremona, Italy

  • Pontificia Universidade

    Porto Alegre, 90610-000, Brazil

  • Princess Alexandra Hospital

    Woolloongabba, Queensland, 4102, Australia

  • Roswell - Roswell Park Cancer Institute - Medical Oncology

    Buffalo, New York, 14263, United States

  • Royal Blackburn Hospital - Oncology

    Preston, Lancashire, PR2 9HT, United Kingdom

  • Royal Derby Hospital

    Derby, DE22 3NE, United Kingdom

  • Royal Marsden - Sutton

    Sutton, Surrey, SM2 5PT, United Kingdom

  • Royal Marsden Hospital

    Sutton, Surrey, SM2 5PT, United Kingdom

  • St. Vincent Frontier Cancer Center

    Billings, Montana, 59102-6746, United States

  • Sunnybrook Research Institute, sunnybrook Health Sciences Ct

    Toronto, Ontario, M4N 3M5, Canada

  • Sunshine Hospital

    Geelong, Victoria, 3220, Australia

  • Szpital Kliniczny Przemienienia Panskiego UM w Poznaniu

    Poznan, Greater Poland Voivodeship, 60-569, Poland

  • Szpital Specjalist. w Brzozowie,Podkarpacki Ośrodek Onkologi

    Brzozów, Podkarpackie Voivodeship, 36-200, Poland

  • Szpital Specjalistyczny im. L. Rydygiera w Krakowie

    Krakow, Lesser Poland Voivodeship, 31-826, Poland

  • Tennessee Oncology, PLLC

    Nashville, Tennessee, 37203, United States

  • Texas Oncology - Baylor Charles A. Sammons Cancer Center

    Dallas, Texas, 75246, United States

  • Texas Oncology - Central Austin Cancer Center

    Austin, Texas, 78731, United States

  • The Christie NHS Foundation Trust - Medical Oncology

    Manchester, Manchester, M20 4BX, United Kingdom

  • The University of Kansas Cancer Center

    Westwood, Kansas, 66205-2005, United States

  • Tom Baker Cancer Centre

    Calgary, Alberta, T2N 4N2, Canada

  • Tulane Cancer Center Clinic - Oncology

    New Orleans, Louisiana, 70112, United States

  • UH Cleveland Medical Center

    Columbia, South Carolina, 29210, United States

  • US Oncology - Rocky Mountain Cancer Centers - Midtown

    Denver, Colorado, 80218-1237, United States

  • US Oncology Texas Oncology (CCC of South Texas) - San Antonio Medical Center

    San Antonio, Texas, 78240, United States

  • UZ Gent - Medische Oncologie

    Ghent, Oost-Vlaanderen, 9000, Belgium

  • Universidade Estadual de Campi

    Campinas, São Paulo, 13083-970, Brazil

  • University Health Network - Princess Margaret Cancer Centre

    Toronto, Ontario, M5G 2M9, Canada

  • University Hospital Brno

    Brno, Brno-město, 625 00, Czechia

  • University Of Washington - Medical Center

    Seattle, Washington, 98109, United States

  • University of California San Diego

    La Jolla, California, 92037, United States

  • University of Kentucky UK Markey Cancer Center

    Lexington, Kentucky, 40536, United States

  • University of Maryland Medical Center-Greenebaum Cancer Ctr

    Baltimore, Maryland, 21201, United States

  • University of New Mexico - Comprehensive Cancer Center

    Albuquerque, New Mexico, 87131-0001, United States

  • Universitätsklinikum Heidelberg

    Heidelberg, Baden-Wurttemberg, 69120, Germany

  • Vanderbilt-Ingram Cancer Center

    Nashville, Tennessee, 37232, United States

  • Wojewodzki Szpital Specjalistyczny

    Biała Podlaska, 21-500, Poland

  • ZNA Jan Palfijn

    Merksen, Antwerpen, 2170, Belgium

Conditions

Explore the condition pages connected to this study.