Promising combo for tough cancers? early trial shows safety
NCT ID NCT03239145
First seen Mar 17, 2026 · Last updated Jun 12, 2026 · Updated 12 times
Summary
This early-phase study tested the safety of combining two drugs—pembrolizumab and AMG386—in 62 people with advanced solid tumors like melanoma, ovarian, kidney, or colorectal cancer. The goal was to find the safest dose and see if the combination could shrink tumors. While the treatment showed some promise, it is not a cure and requires ongoing management.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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Beth Israel Deaconess Medical Center
Boston, Massachusetts, 02215, United States
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Dana Farber Cancer Institute
Boston, Massachusetts, 02215, United States
Conditions
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