New triple therapy aims to boost immune attack on tough cancers

NCT ID NCT04495257

First seen Nov 01, 2025 · Last updated May 12, 2026 · Updated 22 times

Summary

This early-phase study tests whether adding an experimental drug (APX005M) to two standard immunotherapies is safe and tolerable for people with advanced melanoma or kidney cancer. About 26 adults who have not had prior immune therapy for their advanced disease will receive the combination. The main goals are to find the best dose and to monitor side effects.

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Contacts and locations

Locations

  • Yale Cancer Center

    New Haven, Connecticut, 06519, United States

  • Yale New Haven Hospital

    New Haven, Connecticut, 06520, United States

Conditions

Explore the condition pages connected to this study.