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New drug combo aims to extend life in advanced kidney cancer

NCT ID NCT07227402

Recruiting now Disease control Sponsor: Merck Sharp & Dohme LLC Source: ClinicalTrials.gov ↗

First seen Nov 12, 2025 · Last updated May 14, 2026 · Updated 26 times

Summary

This study tests whether a combination of two drugs (belzutifan and zanzalintinib) works better than the standard drug cabozantinib for people with advanced kidney cancer that came back after previous treatment. About 904 participants will be randomly assigned to one of the two treatment groups. The main goals are to see if the new combination helps people live longer and keeps the cancer from growing.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • A.O.U.C. Policlinico di Bari ( Site 1602)

    RECRUITING

    Bari, 70124, Italy

    Contact Phone: •••-•••-••••

  • AIDPORT Sp. z o.o. ( Site 1716)

    RECRUITING

    Skórzewo, Greater Poland Voivodeship, 60-185, Poland

    Contact Phone: •••-•••-••••

  • Aarhus University Hospital Skejby ( Site 1001)

    RECRUITING

    Aarhus, Central Jutland, 8200, Denmark

    Contact Phone: •••-•••-••••

  • Alexandra General Hospital of Athens ( Site 1300)

    RECRUITING

    Athens, Attica, 115 28, Greece

    Contact Phone: •••-•••-••••

  • Asan Medical Center ( Site 2501)

    RECRUITING

    Seoul, 05505, South Korea

    Contact Phone: •••-•••-••••

  • Asociación de Beneficencia Hospital Sirio Libanés ( Site 0205)

    RECRUITING

    Caba, Buenos Aires, C1419AHN, Argentina

    Contact Phone: •••-•••-••••

  • Azienda Ospedaliera Di Rilievo Nazionale A. Cardarelli ( Site 1609)

    RECRUITING

    Naples, Campania, 80131, Italy

    Contact Phone: •••-•••-••••

  • Azienda Ospedaliera S. Luigi Gonzaga ( Site 1607)

    RECRUITING

    Orbassano, Piedmont, 10043, Italy

    Contact Phone: •••-•••-••••

  • Azienda Ospedaliera Universitaria Careggi ( Site 1608)

    RECRUITING

    Florence, Tuscany, 50134, Italy

    Contact Phone: •••-•••-••••

  • Azienda USL 8 di Arezzo ( Site 1605)

    RECRUITING

    Arezzo, 52100, Italy

    Contact Phone: •••-•••-••••

  • CHD Vendee ( Site 1103)

    RECRUITING

    La Roche-sur-Yon, Vendee, 85000, France

    Contact Phone: •••-•••-••••

  • CHU GRENOBLE ALPES ( Site 1101)

    RECRUITING

    La Tronche, Isere, 38700, France

    Contact Phone: •••-•••-••••

  • CHU de Bordeaux Hop St ANDRE ( Site 1115)

    RECRUITING

    Bordeaux, Gironde, 33075, France

    Contact Phone: •••-•••-••••

  • CHU de Rouen ( Site 1108)

    RECRUITING

    Rouen, Seine-Maritime, 76031, France

    Contact Phone: •••-•••-••••

  • CIO - Centro de Inmuno-Oncología de Occidente ( Site 0503)

    RECRUITING

    Guadalajara, Jalisco, 44630, Mexico

    Contact Phone: •••-•••-••••

  • Casa di Cura Dott. Pederzoli - UO Oncologia ( Site 1610)

    RECRUITING

    Peschiera del Garda, Veneto, 37019, Italy

    Contact Phone: •••-•••-••••

  • Centre Hospitalier Universitaire d'Angers-Urology ( Site 1104)

    RECRUITING

    Angers, Pays de la Loire Region, 49933, France

    Contact Phone: •••-•••-••••

  • Centre Hospitalier de la Côte Basque ( Site 1113)

    RECRUITING

    Bayonne, Pyrenees-Atlantiques, 64109, France

    Contact Phone: •••-•••-••••

  • Centre d'Oncologie de Gentilly ( Site 1117)

    RECRUITING

    Nancy, Lorraine, 54100, France

    Contact Phone: •••-•••-••••

  • Centre de Cancérologie du Grand Montpellier ( Site 1112)

    RECRUITING

    Montpellier, Herault, 34070, France

    Contact Phone: •••-•••-••••

  • Centro de Educación Médica e Investigaciones clínicas "Dr. Norberto Quirno" (CEMIC) ( Site 0208)

    RECRUITING

    Caba., Buenos Aires F.D., C1431FWO, Argentina

    Contact Phone: •••-•••-••••

  • Centro de Investigacion Clinica de Oaxaca ( Site 0502)

    RECRUITING

    Oaxaca City, Oaxaca, 68020, Mexico

    Contact Phone: •••-•••-••••

  • Centrum Onkologii im. Prof. Franciszka Lukaszczyka ( Site 1707)

    RECRUITING

    Bydgoszcz, Kuyavian-Pomeranian Voivodeship, 85-796, Poland

    Contact Phone: •••-•••-••••

  • Chang Gung Memorial Hospital - Linkou Branch ( Site 2604)

    RECRUITING

    Taoyuan, 333, Taiwan

    Contact Phone: •••-•••-••••

  • Charité Universitaetsmedizin Berlin - Campus Mitte ( Site 1203)

    RECRUITING

    Berlin, 10117, Germany

    Contact Phone: •••-•••-••••

  • China Medical University Hospital ( Site 2603)

    RECRUITING

    Taichung, 40447, Taiwan

    Contact Phone: •••-•••-••••

  • Chonnam National University Hwasun Hospital ( Site 2505)

    RECRUITING

    Hwasun-gun, Jeonranamdo, 58128, South Korea

    Contact Phone: •••-•••-••••

  • Chungnam National University Hospital ( Site 2506)

    RECRUITING

    Taejŏn, Taejon-Kwangyokshi, 35015, South Korea

    Contact Phone: •••-•••-••••

  • Clinica Integral Internacional de Oncología ( Site 0506)

    RECRUITING

    Puebla City, 72530, Mexico

    Contact Phone: •••-•••-••••

  • Cliniques Universitaires Saint-Luc ( Site 0703)

    RECRUITING

    Brussels, Bruxelles-Capitale, Region de, 1200, Belgium

    Contact Phone: •••-•••-••••

  • Cork University Hospital ( Site 1501)

    RECRUITING

    Cork, T12 YK23, Ireland

    Contact Phone: •••-•••-••••

  • Fakultni nemocnice Hradec Kralove ( Site 0902)

    RECRUITING

    Hradec Králové, 500 05, Czechia

    Contact Phone: •••-•••-••••

  • Fakultni nemocnice Olomouc ( Site 0901)

    RECRUITING

    Olomouc, 779 00, Czechia

    Contact Phone: •••-•••-••••

  • Fakultni nemocnice Ostrava ( Site 0904)

    RECRUITING

    Ostrava, Ostrava Mesto, 708 52, Czechia

    Contact Phone: •••-•••-••••

  • Fakultni nemocnice v Motole ( Site 0900)

    RECRUITING

    Prague, 150 06, Czechia

    Contact Phone: •••-•••-••••

  • Fondazione IRCCS Istituto Nazionale dei Tumori ( Site 1600)

    RECRUITING

    Milan, Milano, 20133, Italy

    Contact Phone: •••-•••-••••

  • Fondazione Policlinico Universitario Agostino Gemelli IRCCS - Università Cattolica del Sacro Cuore ( Site 1601)

    RECRUITING

    Rome, Roma, 00618, Italy

    Contact Phone: •••-•••-••••

  • Fundación Instituto Valenciano de Oncología ( Site 1808)

    RECRUITING

    Valencia, Valenciana, Comunitat, 46009, Spain

    Contact Phone: •••-•••-••••

  • Fundação Faculdade Regional de Medicina de São José do Rio Preto ( Site 0302)

    RECRUITING

    São José do Rio Preto, São Paulo, 15090-000, Brazil

    Contact Phone: •••-•••-••••

  • HELIOS Klinikum Erfurt ( Site 1208)

    RECRUITING

    Erfurt, Thuringia, 99089, Germany

    Contact Phone: •••-•••-••••

  • HENRI MONDOR HOSPITAL ( Site 1116)

    RECRUITING

    Créteil, Val-de-Marne, 94010, France

    Contact Phone: •••-•••-••••

  • Helios Kliniken Schwerin GmbH ( Site 1206)

    RECRUITING

    Schwerin, Mecklenburg-Vorpommern, 19055, Germany

    Contact Phone: •••-•••-••••

  • Herlev Hospital ( Site 1002)

    RECRUITING

    Herlev, Capital Region, 2730, Denmark

    Contact Phone: •••-•••-••••

  • Higiea Oncologia ( Site 0504)

    RECRUITING

    Mexico City, 11810, Mexico

    Contact Phone: •••-•••-••••

  • Hospital Aleman ( Site 0204)

    RECRUITING

    CABA, Buenos Aires, C1118AAT, Argentina

    Contact Phone: •••-•••-••••

  • Hospital Alemao Oswaldo Cruz ( Site 0311)

    RECRUITING

    São Paulo, São Paulo, 01327-001, Brazil

    Contact Phone: •••-•••-••••

  • Hospital Clinic de Barcelona ( Site 1810)

    RECRUITING

    Barcelona, 08036, Spain

    Contact Phone: •••-•••-••••

  • Hospital Clinico San Carlos ( Site 1802)

    RECRUITING

    Madrid, 28040, Spain

    Contact Phone: •••-•••-••••

  • Hospital Italiano de Buenos Aires. ( Site 0203)

    RECRUITING

    Caba, Buenos Aires, C1199ABB, Argentina

    Contact Phone: •••-•••-••••

  • Hospital Moinhos de Vento ( Site 0309)

    RECRUITING

    Porto Alegre, Rio Grande do Sul, 90560-032, Brazil

    Contact Phone: •••-•••-••••

  • Hospital Privado Universitario de Córdoba ( Site 0207)

    RECRUITING

    Córdoba, X5016KEH, Argentina

    Contact Phone: •••-•••-••••

  • Hospital Universitari Vall d'Hebron ( Site 1804)

    RECRUITING

    Barcelona, 08035, Spain

    Contact Phone: •••-•••-••••

  • Hospital Universitario 12 de Octubre ( Site 1800)

    RECRUITING

    Madrid, 28041, Spain

    Contact Phone: •••-•••-••••

  • Hospital Universitario Fundacion Jimenez Diaz ( Site 1803)

    RECRUITING

    Madrid, 28040, Spain

    Contact Phone: •••-•••-••••

  • Hospital Universitario Marqués de Valdecilla ( Site 1807)

    RECRUITING

    Santander, Cantabria, 39008, Spain

    Contact Phone: •••-•••-••••

  • Hospital Universitario Ramón y Cajal ( Site 1801)

    RECRUITING

    Madrid, Madrid, Comunidad de, 28034, Spain

    Contact Phone: •••-•••-••••

  • Hospital Universitario Reina Sofia ( Site 1809)

    RECRUITING

    Córdoba, 14004, Spain

    Contact Phone: •••-•••-••••

  • Hôpital Foch ( Site 1118)

    RECRUITING

    Suresnes, Hauts-de-Seine, 92150, France

    Contact Phone: •••-•••-••••

  • I CAN ONCOLOGY CENTER S.A. DE C.V. ( Site 0507)

    RECRUITING

    Monterrey, Nuevo León, 64710, Mexico

    Contact Phone: •••-•••-••••

  • IPC - MT Instituto de Pesquisas Clínicas do Mato Grosso ( Site 0305)

    RECRUITING

    Cuiabá, Mato Grosso, 78020-500, Brazil

    Contact Phone: •••-•••-••••

  • IRCCS Azienda Ospedaliero-Universitaria di Bologna, Policlinico di Sant'Orsola ( Site 1604)

    RECRUITING

    Bologna, 40138, Italy

    Contact Phone: •••-•••-••••

  • Institut Català d'Oncologia (ICO) - Girona ( Site 1806)

    RECRUITING

    Girona, Gerona, 17007, Spain

    Contact Phone: •••-•••-••••

  • Institut Català d'Oncologia - L'Hospitalet ( Site 1805)

    RECRUITING

    L'Hospitalet de Llobregat, Barcelona, 08908, Spain

    Contact Phone: •••-•••-••••

  • Instituto Alexander Fleming ( Site 0202)

    RECRUITING

    CABA, Buenos Aires, C1426ANZ, Argentina

    Contact Phone: •••-•••-••••

  • Instituto de Oncología de Rosario ( Site 0209)

    RECRUITING

    Rosario, Santa Fe Province, S2000KZE, Argentina

    Contact Phone: •••-•••-••••

  • Istituto Clinico Humanitas ( Site 1613)

    RECRUITING

    Rozzano, Milano, 20089, Italy

    Contact Phone: •••-•••-••••

  • Istituto Nazionale Tumori Regina Elena ( Site 1611)

    RECRUITING

    Rome, Lazio, 00144, Italy

    Contact Phone: •••-•••-••••

  • Klinikum Stuttgart - Katharinenhospital ( Site 1201)

    RECRUITING

    Stuttgart, Baden-Wurttemberg, 70174, Germany

    Contact Phone: •••-•••-••••

  • Klinički Bolnički Centar Split ( Site 0802)

    RECRUITING

    Split, Split-Dalmatia County, 21000, Croatia

    Contact Phone: •••-•••-••••

  • Liga Norte Riograndense Contra o Câncer ( Site 0307)

    RECRUITING

    Natal, Rio Grande do Norte, 59062-000, Brazil

    Contact Phone: •••-•••-••••

  • MTZ Clinical Research Powered by Pratia ( Site 1705)

    RECRUITING

    Warsaw, Masovian Voivodeship, 02-172, Poland

    Contact Phone: •••-•••-••••

  • Macquarie University-MQ Health Clinical Trials Unit ( Site 2100)

    RECRUITING

    Sydney, New South Wales, 2109, Australia

    Contact Phone: •••-•••-••••

  • Marienhospital Herne ( Site 1215)

    RECRUITING

    Herne, North Rhine-Westphalia, 44625, Germany

    Contact Phone: •••-•••-••••

  • Masarykuv onkologicky ustav ( Site 0903)

    RECRUITING

    Brno, Brno-mesto, 656 53, Czechia

    Contact Phone: •••-•••-••••

  • Mazowiecki Szpital Wojewódzki w Siedlcach-Siedleckie Centrum Onkologii ( Site 1702)

    RECRUITING

    Siedlce, Masovian Voivodeship, 08-110, Poland

    Contact Phone: •••-•••-••••

  • Medizinische Universitat Wien ( Site 0601)

    RECRUITING

    Vienna, 1090, Austria

    Contact Phone: •••-•••-••••

  • Metropolitan Hospital ( Site 1302)

    RECRUITING

    Athens, Attica, 185 47, Greece

    Contact Phone: •••-•••-••••

  • National Cancer Centre Singapore ( Site 2401)

    RECRUITING

    Singapore, Central Singapore, 168583, Singapore

    Contact Phone: •••-•••-••••

  • National University Hospital ( Site 2400)

    RECRUITING

    Singapore, Central Singapore, 119074, Singapore

    Contact Phone: •••-•••-••••

  • Nemocnice České Budějovice ( Site 0905)

    RECRUITING

    České Budějovice, 370 01, Czechia

    Contact Phone: •••-•••-••••

  • Odense Universitetshospital ( Site 1000)

    RECRUITING

    Odense, Region Syddanmark, 9000, Denmark

    Contact Phone: •••-•••-••••

  • Ordensklinikum Linz GmbH Elisabethinen-Urologie ( Site 0600)

    RECRUITING

    Linz, Upper Austria, 4020, Austria

    Contact Phone: •••-•••-••••

  • Ospedale San Martino ( Site 1606)

    RECRUITING

    Genova, 16132, Italy

    Contact Phone: •••-•••-••••

  • Pratia MCM Krakow ( Site 1713)

    RECRUITING

    Krakow, Lesser Poland Voivodeship, 30-727, Poland

    Contact Phone: •••-•••-••••

  • Prince of Wales Hospital ( Site 2200)

    RECRUITING

    Hong Kong, Hong Kong

    Contact Phone: •••-•••-••••

  • Queen Mary Hospital ( Site 2201)

    RECRUITING

    Hong Kong, Hong Kong

    Contact Phone: •••-•••-••••

  • Samsung Medical Center ( Site 2502)

    RECRUITING

    Seoul, 06351, South Korea

    Contact Phone: •••-•••-••••

  • Sanatorio Parque ( Site 0201)

    RECRUITING

    Rosario, Santa Fe Province, S2000DSV, Argentina

    Contact Phone: •••-•••-••••

  • Seoul National University Bundang Hospital ( Site 2504)

    RECRUITING

    Seongnam, Kyonggi-do, 13620, South Korea

    Contact Phone: •••-•••-••••

  • Severance Hospital, Yonsei University Health System ( Site 2503)

    RECRUITING

    Seoul, 03722, South Korea

    Contact Phone: •••-•••-••••

  • Szpital Specjalistyczny im. Ludwika Rydygiera w Krakowie ( Site 1703)

    RECRUITING

    Krakow, Lesser Poland Voivodeship, 31-826, Poland

    Contact Phone: •••-•••-••••

  • Szpital Wojewodzki im. Mikolaja Kopernika w Koszalinie ( Site 1701)

    RECRUITING

    Koszalin, West Pomeranian Voivodeship, 75-581, Poland

    Contact Phone: •••-•••-••••

  • Taichung Veterans General Hospital ( Site 2602)

    RECRUITING

    Taichung, 40705, Taiwan

    Contact Phone: •••-•••-••••

  • Taipei Veterans General Hospital ( Site 2600)

    RECRUITING

    Taipei, 11217, Taiwan

    Contact Phone: •••-•••-••••

  • Tallaght University Hospital ( Site 1500)

    RECRUITING

    Dublin, D24 NR0A, Ireland

    Contact Phone: •••-•••-••••

  • UZ Gent ( Site 0702)

    RECRUITING

    Ghent, Oost-Vlaanderen, 9000, Belgium

    Contact Phone: •••-•••-••••

  • UZ Leuven ( Site 0700)

    RECRUITING

    Leuven, Vlaams-Brabant, 3000, Belgium

    Contact Phone: •••-•••-••••

  • UniversitaetsklInikum Tuebingen ( Site 1207)

    RECRUITING

    Tübingen, Baden-Wurttemberg, 72076, Germany

    Contact Phone: •••-•••-••••

  • Universitaetsklinikum Carl Gustav Carus Dresden ( Site 1213)

    RECRUITING

    Dresden, Saxony, 01307, Germany

    Contact Phone: •••-•••-••••

  • Universitaetsklinikum Hamburg-Eppendorf ( Site 1214)

    RECRUITING

    Hamburg, 20246, Germany

    Contact Phone: •••-•••-••••

  • Universitaetsklinikum Muenster ( Site 1202)

    RECRUITING

    Münster, North Rhine-Westphalia, 70174, Germany

    Contact Phone: •••-•••-••••

  • University General Hospital ''Attikon'' - General Hospital of West Attica "H AGIA VARVARA" ( Site 1301)

    RECRUITING

    Chaïdári, Attica, 124 62, Greece

    Contact Phone: •••-•••-••••

  • Universitätsklinikum Jena ( Site 1204)

    RECRUITING

    Jena, Thuringia, 07747, Germany

    Contact Phone: •••-•••-••••

  • Universitätsmedizin Göttingen - Georg-August-Universität ( Site 1211)

    RECRUITING

    Göttingen, Lower Saxony, 37075, Germany

    Contact Phone: •••-•••-••••

  • Vseobecna fakultni nemocnice v Praze ( Site 0906)

    RECRUITING

    Prague, 128 08, Czechia

    Contact Phone: •••-•••-••••

  • Wojewodzki Szpital im. Sw. Ojca Pio w Przemyslu ( Site 1710)

    RECRUITING

    Przemyśl, Podkarpackie Voivodeship, 37-700, Poland

    Contact Phone: •••-•••-••••

  • Ziekenhuis Oost-Limburg, Campus St.-Jan ( Site 0701)

    RECRUITING

    Genk, Limburg, 3600, Belgium

    Contact Phone: •••-•••-••••

  • centre hospitalier lyon sud ( Site 1102)

    RECRUITING

    Pierre-Bénite, Rhone, 69310, France

    Contact Phone: •••-•••-••••

Conditions

Explore the condition pages connected to this study.

RENAL CELL CARCINOMA