New drug combo aims to fight advanced kidney cancer

NCT ID NCT07227402

Recruiting now Disease control Sponsor: Merck Sharp & Dohme LLC Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Aug 04, 2026 · Updated 9 times

Summary

This study tests whether a combination of two oral drugs, belzutifan and zanzalintinib, works better than the current standard drug cabozantinib for people with advanced kidney cancer that has come back after prior treatment. About 904 participants will be randomly assigned to one of the two treatment groups. The main goals are to see if the new combination helps people live longer or delays cancer progression.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: belzutifan and zanzalintinib (drugs taken by mouth)
What this could lead to: If this works, it could offer a new treatment option that helps people with advanced kidney cancer live longer or delay cancer growth.
What could go wrong: This is an early-stage Phase 3 trial, so results are not guaranteed. The new drug combination may not be better than the existing treatment and could have side effects.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

carcinoma clear cell renal carcinoma renal cell carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

RENAL CELL CARCINOMA

Contacts and locations

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Study contacts

Contact

Email: •••••@•••••

Locations

A.O.U.C. Policlinico di Bari ( Site 1602)
RECRUITING

Bari, 70124, Italy
AIDPORT Sp. z o.o. ( Site 1716)
RECRUITING

Skórzewo, Greater Poland Voivodeship, 60-185, Poland
Aarhus University Hospital Skejby ( Site 1001)
RECRUITING

Aarhus, Central Jutland, 8200, Denmark
Addenbrookes Hospital ( Site 2005)
RECRUITING

Cambridge, Cambridgeshire, CB2 0QQ, United Kingdom
Alaska Oncology and Hematology ( Site 0133)
RECRUITING

Anchorage, Alaska, 99508, United States
Alexandra General Hospital of Athens ( Site 1300)
RECRUITING

Athens, Attica, 115 28, Greece
Asan Medical Center ( Site 2501)
RECRUITING

Seoul, 05505, South Korea
Asociación de Beneficencia Hospital Sirio Libanés ( Site 0205)
RECRUITING

Caba, Buenos Aires, C1419AHN, Argentina
Azienda Ospedaliera Di Rilievo Nazionale A. Cardarelli ( Site 1609)
RECRUITING

Naples, Campania, 80131, Italy
Azienda Ospedaliera S. Luigi Gonzaga ( Site 1607)
RECRUITING

Orbassano, Piedmont, 10043, Italy
Azienda Ospedaliera Universitaria Careggi ( Site 1608)
RECRUITING

Florence, Tuscany, 50134, Italy
Azienda Ospedaliera Universitaria di Parma ( Site 1603)
RECRUITING

Parma, 43126, Italy
Azienda USL 8 di Arezzo ( Site 1605)
RECRUITING

Arezzo, 52100, Italy
CHD Vendee ( Site 1103)
RECRUITING

La Roche-sur-Yon, Vendee, 85000, France
CHU GRENOBLE ALPES ( Site 1101)
RECRUITING

La Tronche, Isere, 38700, France
CHU de Bordeaux Hop St ANDRE ( Site 1115)
RECRUITING

Bordeaux, Gironde, 33075, France
CHU de Rouen ( Site 1108)
RECRUITING

Rouen, Seine-Maritime, 76031, France
CIO - Centro de Inmuno-Oncología de Occidente ( Site 0503)
RECRUITING

Guadalajara, Jalisco, 44630, Mexico
Carolina Oncology Specialists, PA ( Site 9002)
RECRUITING

Charlotte, North Carolina, 28207, United States
Casa di Cura Dott. Pederzoli - UO Oncologia ( Site 1610)
RECRUITING

Peschiera del Garda, Veneto, 37019, Italy
Cedars-Sinai Medical Center ( Site 0112)
RECRUITING

Los Angeles, California, 90048, United States
Centre Hospitalier Universitaire d'Angers-Urology ( Site 1104)
RECRUITING

Angers, Pays de la Loire Region, 49933, France
Centre Hospitalier de la Cote Basque ( Site 1113)
RECRUITING

Bayonne, Pyrenees-Atlantiques, 64109, France
Centre d'Oncologie de Gentilly ( Site 1117)
RECRUITING

Nancy, Lorraine, 54100, France
Centre de Cancérologie du Grand Montpellier ( Site 1112)
RECRUITING

Montpellier, Herault, 34070, France
Centro de Educación Médica e Investigaciones clínicas "Dr. Norberto Quirno" (CEMIC) ( Site 0208)
RECRUITING

Caba., Buenos Aires F.D., C1431FWO, Argentina
Centro de Investigacion Clinica UC CICUC ( Site 0402)
RECRUITING

Santiago, Region M. de Santiago, 833000, Chile
Centro de Investigacion Clinica de Oaxaca ( Site 0502)
RECRUITING

Oaxaca City, Oaxaca, 68020, Mexico
Chang Gung Memorial Hospital - Linkou Branch ( Site 2604)
RECRUITING

Taoyuan, 333, Taiwan
Charité Universitaetsmedizin Berlin - Campus Mitte ( Site 1203)
RECRUITING

Berlin, 10117, Germany
China Medical University Hospital ( Site 2603)
RECRUITING

Taichung, 40447, Taiwan
Chonnam National University Hwasun Hospital ( Site 2505)
RECRUITING

Hwasun-gun, Jeonranamdo, 58128, South Korea
Chungnam National University Hospital ( Site 2506)
RECRUITING

Taejŏn, Taejon-Kwangyokshi, 35015, South Korea
Clinica Integral Internacional de Oncología ( Site 0506)
RECRUITING

Puebla City, 72530, Mexico
Cliniques Universitaires Saint-Luc ( Site 0703)
RECRUITING

Brussels, Bruxelles-Capitale, Region de, 1200, Belgium
Cork University Hospital ( Site 1501)
RECRUITING

Cork, T12 YK23, Ireland
Fakultni nemocnice Hradec Kralove ( Site 0902)
RECRUITING

Hradec Králové, 500 05, Czechia
Fakultni nemocnice Olomouc ( Site 0901)
RECRUITING

Olomouc, 779 00, Czechia
Fakultni nemocnice Ostrava ( Site 0904)
RECRUITING

Ostrava, Ostrava Mesto, 708 52, Czechia
Fakultni nemocnice v Motole ( Site 0900)
RECRUITING

Prague, 150 06, Czechia
Fondazione IRCCS Istituto Nazionale dei Tumori ( Site 1600)
RECRUITING

Milan, Milano, 20133, Italy
Fondazione Policlinico Universitario Agostino Gemelli IRCCS - Università Cattolica del Sacro Cuore ( Site 1601)
RECRUITING

Rome, Roma, 00618, Italy
Fundacion Arturo Lopez Perez ( Site 0401)
RECRUITING

Santiago, Region M. de Santiago, 7500921, Chile
Fundación Instituto Valenciano de Oncología ( Site 1808)
RECRUITING

Valencia, Valenciana, Comunitat, 46009, Spain
Fundação Faculdade Regional de Medicina de São José do Rio Preto ( Site 0302)
RECRUITING

São José do Rio Preto, São Paulo, 15090-000, Brazil
Greater Baltimore Medical Center ( Site 0145)
RECRUITING

Baltimore, Maryland, 21204, United States
HELIOS Klinikum Erfurt ( Site 1208)
RECRUITING

Erfurt, Thuringia, 99089, Germany
HENRI MONDOR HOSPITAL ( Site 1116)
RECRUITING

Créteil, Val-de-Marne, 94010, France
Helios Kliniken Schwerin GmbH ( Site 1206)
RECRUITING

Schwerin, Mecklenburg-Vorpommern, 19055, Germany
Herlev Hospital ( Site 1002)
RECRUITING

Herlev, Capital Region, 2730, Denmark
Higiea Oncologia ( Site 0504)
RECRUITING

Mexico City, 11810, Mexico
Hospital Aleman ( Site 0204)
RECRUITING

CABA, Buenos Aires, C1118AAT, Argentina
Hospital Alemao Oswaldo Cruz ( Site 0311)
RECRUITING

São Paulo, São Paulo, 01327-001, Brazil
Hospital Clinic de Barcelona ( Site 1810)
RECRUITING

Barcelona, 08036, Spain
Hospital Clinico San Carlos ( Site 1802)
RECRUITING

Madrid, 28040, Spain
Hospital Italiano de Buenos Aires. ( Site 0203)
RECRUITING

Caba, Buenos Aires, C1199ABB, Argentina
Hospital Moinhos de Vento ( Site 0309)
RECRUITING

Porto Alegre, Rio Grande do Sul, 90560-032, Brazil
Hospital Privado Universitario de Córdoba ( Site 0207)
RECRUITING

Córdoba, X5016KEH, Argentina
Hospital Universitari Vall d'Hebron ( Site 1804)
RECRUITING

Barcelona, 08035, Spain
Hospital Universitario 12 de Octubre ( Site 1800)
RECRUITING

Madrid, 28041, Spain
Hospital Universitario Austral ( Site 0212)
RECRUITING

Pilar, Buenos Aires, B1629AHJ, Argentina
Hospital Universitario Fundacion Jimenez Diaz ( Site 1803)
RECRUITING

Madrid, 28040, Spain
Hospital Universitario Marqués de Valdecilla ( Site 1807)
RECRUITING

Santander, Cantabria, 39008, Spain
Hospital Universitario Ramón y Cajal ( Site 1801)
RECRUITING

Madrid, Madrid, Comunidad de, 28034, Spain
Hospital Universitario Reina Sofia ( Site 1809)
RECRUITING

Córdoba, 14004, Spain
Hôpital Foch ( Site 1118)
RECRUITING

Suresnes, Hauts-de-Seine, 92150, France
I CAN ONCOLOGY CENTER S.A. DE C.V. ( Site 0507)
RECRUITING

Monterrey, Nuevo León, 64710, Mexico
IPC - MT Instituto de Pesquisas Clínicas do Mato Grosso ( Site 0305)
RECRUITING

Cuiabá, Mato Grosso, 78020-500, Brazil
IRCCS Azienda Ospedaliero-Universitaria di Bologna, Policlinico di Sant'Orsola ( Site 1604)
RECRUITING

Bologna, 40138, Italy
Institut Català d'Oncologia (ICO) - Girona ( Site 1806)
RECRUITING

Girona, Gerona, 17007, Spain
Institut Català d'Oncologia - L'Hospitalet ( Site 1805)
RECRUITING

L'Hospitalet de Llobregat, Barcelona, 08908, Spain
Instituto Alexander Fleming ( Site 0202)
RECRUITING

CABA, Buenos Aires, C1426ANZ, Argentina
Instituto de Oncología de Rosario ( Site 0209)
RECRUITING

Rosario, Santa Fe Province, S2000KZE, Argentina
Istituto Clinico Humanitas ( Site 1613)
RECRUITING

Rozzano, Milano, 20089, Italy
Istituto Nazionale Tumori Regina Elena ( Site 1611)
RECRUITING

Rome, Lazio, 00144, Italy
Istituto Oncologico Veneto IRCCS ( Site 1612)
RECRUITING

Castelfranco Veneto, Veneto, 31033, Italy
Klinikum Stuttgart - Katharinenhospital ( Site 1201)
RECRUITING

Stuttgart, Baden-Wurttemberg, 70174, Germany
Klinički Bolnički Centar Split ( Site 0802)
RECRUITING

Split, Split-Dalmatia County, 21000, Croatia
Klinički bolnički centar Sestre milosrdnice ( Site 0801)
RECRUITING

Zagreb, City of Zagreb, 10000, Croatia
Klinički bolnički centar Zagreb ( Site 0800)
RECRUITING

Zagreb, City of Zagreb, 10000, Croatia
Liga Norte Riograndense Contra o Câncer ( Site 0307)
RECRUITING

Natal, Rio Grande do Norte, 59062-000, Brazil
MTZ Clinical Research Powered by Pratia ( Site 1705)
RECRUITING

Warsaw, Masovian Voivodeship, 02-172, Poland
Macquarie University-MQ Health Clinical Trials Unit ( Site 2100)
RECRUITING

Sydney, New South Wales, 2109, Australia
Marienhospital Herne ( Site 1215)
RECRUITING

Herne, North Rhine-Westphalia, 44625, Germany
Masarykuv onkologicky ustav ( Site 0903)
RECRUITING

Brno, Brno-mesto, 656 53, Czechia
Mazowiecki Szpital Wojewódzki w Siedlcach-Siedleckie Centrum Onkologii ( Site 1702)
RECRUITING

Siedlce, Masovian Voivodeship, 08-110, Poland
Medizinische Universitat Wien ( Site 0601)
RECRUITING

Vienna, 1090, Austria
Metro-Minnesota Community Clinical Oncology ( Site 0144)
RECRUITING

Saint Louis Park, Minnesota, 55426, United States
Metropolitan Hospital ( Site 1302)
RECRUITING

Athens, Attica, 185 47, Greece
National Cancer Centre Singapore ( Site 2401)
RECRUITING

Singapore, Central Singapore, 168583, Singapore
National University Hospital ( Site 2400)
RECRUITING

Singapore, Central Singapore, 119074, Singapore
Nemocnice České Budějovice ( Site 0905)
RECRUITING

České Budějovice, 370 01, Czechia
New England Cancer Specialists ( Site 0132)
RECRUITING

Westbrook, Maine, 04092, United States
Odense Universitetshospital ( Site 1000)
RECRUITING

Odense, Region Syddanmark, 9000, Denmark
Oncocentro Valdivia ( Site 0408)
RECRUITING

Valdivia, Los Ríos Region, 5112129, Chile
Oncology Hematology West P.C. dba Nebraska Cancer Specialists ( Site 0131)
RECRUITING

Omaha, Nebraska, 68130-2042, United States
Ordensklinikum Linz GmbH Elisabethinen-Urologie ( Site 0600)
RECRUITING

Linz, Upper Austria, 4020, Austria
Ospedale San Martino ( Site 1606)
RECRUITING

Genova, 16132, Italy
Pratia MCM Krakow ( Site 1713)
RECRUITING

Krakow, Lesser Poland Voivodeship, 30-727, Poland
Prince of Wales Hospital ( Site 2200)
RECRUITING

Hong Kong, Hong Kong
Providence Medical Foundation ( Site 0141)
RECRUITING

Fullerton, California, 92835, United States
Queen Mary Hospital ( Site 2201)
RECRUITING

Hong Kong, Hong Kong
Samsung Medical Center ( Site 2502)
RECRUITING

Seoul, 06351, South Korea
Sanatorio Parque ( Site 0201)
RECRUITING

Rosario, Santa Fe Province, S2000DSV, Argentina
Seoul National University Bundang Hospital ( Site 2504)
RECRUITING

Seongnam, Kyonggi-do, 13620, South Korea
Severance Hospital, Yonsei University Health System ( Site 2503)
RECRUITING

Seoul, 03722, South Korea
Szpital Specjalistyczny im. Ludwika Rydygiera w Krakowie ( Site 1703)
RECRUITING

Krakow, Lesser Poland Voivodeship, 31-826, Poland
Szpital Wojewodzki im. Mikolaja Kopernika w Koszalinie ( Site 1701)
RECRUITING

Koszalin, West Pomeranian Voivodeship, 75-581, Poland
Taichung Veterans General Hospital ( Site 2602)
RECRUITING

Taichung, 40705, Taiwan
Taipei Veterans General Hospital ( Site 2600)
RECRUITING

Taipei, 11217, Taiwan
Tallaght University Hospital ( Site 1500)
RECRUITING

Dublin, D24 NR0A, Ireland
Thompson Cancer Survival Center ( Site 0125)
RECRUITING

Knoxville, Tennessee, 37916, United States
USC Norris Comprehensive Cancer Center ( Site 0126)
RECRUITING

Los Angeles, California, 90033, United States
UZ Gent ( Site 0702)
RECRUITING

Ghent, Oost-Vlaanderen, 9000, Belgium
UZ Leuven ( Site 0700)
RECRUITING

Leuven, Vlaams-Brabant, 3000, Belgium
UniversitaetsklInikum Tuebingen ( Site 1207)
RECRUITING

Tübingen, Baden-Wurttemberg, 72076, Germany
Universitaetsklinikum Carl Gustav Carus Dresden ( Site 1213)
RECRUITING

Dresden, Saxony, 01307, Germany
Universitaetsklinikum Hamburg-Eppendorf ( Site 1214)
RECRUITING

Hamburg, 20246, Germany
Universitaetsklinikum Muenster ( Site 1202)
RECRUITING

Münster, North Rhine-Westphalia, 70174, Germany
University General Hospital ''Attikon'' - General Hospital of West Attica "H AGIA VARVARA" ( Site 1301)
RECRUITING

Chaïdári, Attica, 124 62, Greece
Universitätsklinikum Jena ( Site 1204)
RECRUITING

Jena, Thuringia, 07747, Germany
Universitätsmedizin Göttingen - Georg-August-Universität ( Site 1211)
RECRUITING

Göttingen, Lower Saxony, 37075, Germany
Vseobecna fakultni nemocnice v Praze ( Site 0906)
RECRUITING

Prague, 128 08, Czechia
Wojewodzki Szpital im. Sw. Ojca Pio w Przemyslu ( Site 1710)
RECRUITING

Przemyśl, Podkarpackie Voivodeship, 37-700, Poland
Zakład Diagnostyki Laboratoryjnej, Centrum Onkologii ( Site 1707)
RECRUITING

Bydgoszcz, Kuyavian-Pomeranian Voivodeship, 85-796, Poland
Ziekenhuis Oost-Limburg, Campus St.-Jan ( Site 0701)
RECRUITING

Genk, Limburg, 3600, Belgium
centre hospitalier lyon sud ( Site 1102)
RECRUITING

Pierre-Bénite, Rhone, 69310, France

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