New pill-and-immunotherapy cocktail takes on advanced tumors
NCT ID NCT06362369
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests an experimental oral drug called Alintegimod (7HP349) combined with two standard immunotherapies (ipilimumab and nivolumab) in people with advanced solid tumors like melanoma, lung, kidney, and liver cancers. The trial has two parts: first, finding a safe dose (phase 1b), then comparing the combo against standard treatment (phase 2a). About 126 participants will be enrolled. The goal is to see if the combination is safe and helps shrink tumors.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Alintegimod (oral drug) combined with ipilimumab and nivolumab (immunotherapies)
- What this could lead to
- If successful, this could offer a new treatment option for people with advanced cancers that have not responded to prior therapies.
- What could go wrong
- This is an early-phase trial (phase 1b/2a) with a small number of participants, so safety and effectiveness are not yet proven. There is a risk of side effects from the drug combination.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for ADVANCED CANCER are added.
By submitting, you agree to our Terms of use
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Show contact details
Enter your email to view the contact information for this study.
By submitting, you agree to our Terms of use
Study contacts
-
Contact
Phone: •••-•••-•••• Email: •••••@•••••
-
Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
-
Brown University Health Cancer Institute
RECRUITINGProvidence, Rhode Island, 02906, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
-
Dartmouth Hitchcock
RECRUITINGLebanon, New Hampshire, 03756, United States
Contact
Contact Phone: •••-•••-••••
-
Florida Cancer Specialists
COMPLETEDLake Mary, Florida, 32746, United States
-
MD Anderson Cancer Center
RECRUITINGHouston, Texas, 77030, United States
Contact
Contact Phone: •••-•••-••••
-
University of Colorado Cancer Center
RECRUITINGAurora, Colorado, 84005, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Can a Chest-Injected drug drain Cancer's fluid trap?
- Can a cancer vaccine prime the body to better fight liver tumors?
- Can a Two-Pronged antibody boost Chemo's power against lung cancer?
- Can we predict who will survive a bowel surgery leak?
- Can a radioactive tracer reveal whether immunotherapy is working?
- Could an AI-Designed pill take on Hard-to-Treat cancers?