Metastatic neoplasm

This early-phase trial tests a new mRNA vaccine called PAN-NeoVax, designed by artificial intelligence to target multiple cancer types. The vaccine is injected directly into tumors in 9 patients with advanced solid cancers who have run out of standard options. The main goal is to…

This phase III trial is testing whether a precise, high-dose radiation technique called stereotactic radiosurgery (SRS) is better at preserving memory and thinking than the current standard of whole brain radiation that avoids the hippocampus (the brain's memory center) plus a dr…

This early-stage study tests a new drug called AO-252 in people with advanced solid tumors, including those that have spread to the brain. The main goals are to check safety, find the best dose, and see if the drug can shrink tumors or stop them from growing. About 86 adults whos…

This study tests whether adding a new targeted medicine (vepugratinib) to two standard cancer drugs can help people with advanced bladder cancer that has a specific genetic change (FGFR3). About 450 adults whose cancer has spread or cannot be removed by surgery will take part. Th…

This phase III trial tests whether proton craniospinal irradiation (pCSI) can improve survival compared to standard involved-field radiation therapy (IFRT) for patients with breast or non-small cell lung cancer that has spread to the lining of the brain and spinal cord (leptomeni…

This study tests whether a combination of two drugs (ZEN003694 and talazoparib) can shrink tumors in people with advanced solid cancers that have stopped responding to standard treatments. About 88 adults will take part. Researchers will also look at participants' genes to see if…

This early-phase trial tests a new drug called metarrestin in people with advanced solid tumors that have spread (metastasized). The goal is to find a safe dose and see if it can shrink tumors. The study includes adults with pancreatic, breast, or other solid tumors, and children…

This Phase III trial tests whether giving radiation in three smaller doses (FSRS) works better than a single large dose (SRS) for cancer that has spread to the brain. About 269 adults with lung, breast, melanoma, kidney, or gastrointestinal cancers will be randomly assigned to on…

This study tests personalized radiotherapy approaches for people with lung cancer, brain metastases, or other solid tumors. It aims to see if adapting radiation based on how a patient responds is safe and effective. About 45 adults will participate, receiving either extra radiati…

This early-phase trial is testing a new drug, FOG-001, in about 595 people with advanced or metastatic solid tumors, including colorectal, prostate, and liver cancers. The drug is given alone or with other cancer treatments to see if it is safe and shrinks tumors. The study is cu…

This phase 2 trial is testing a type of radiation called craniospinal irradiation that avoids the hippocampus, a brain area key for memory. It is for people with breast or lung cancer that has spread to the fluid and lining around the brain and spinal cord. The goal is to see if …

This study tests a new drug called CR-001 in adults with advanced solid tumors that have spread. The goal is to find the safest dose and see if it can shrink tumors. About 290 people will take part in this early-phase trial.

This early-stage trial tests two experimental pills (PF-07799544 and PF-07799933) taken twice daily at home by adults with advanced solid tumors that have a specific gene change called BRAF V600. The study aims to find safe doses and see if the drugs can shrink tumors. About 124 …

This phase 2 trial is testing a combination of three drugs—datopotamab deruxtecan, carboplatin, and pembrolizumab—in 46 people with non-small cell lung cancer that has spread to the brain and who have not had prior treatment for those brain tumors. The goal is to see how well the…

This trial tests whether delivering chemotherapy directly to the liver through a pump, combined with standard systemic chemotherapy, can shrink liver tumors from colorectal cancer enough to allow surgery. The study enrolls people whose liver metastases are initially inoperable bu…

This early-phase trial tests a new drug called MRG007 (ARR-217) in people with advanced solid tumors that have not responded to standard treatments. The study aims to find a safe dose and check if the drug can shrink tumors. About 405 participants with colorectal, gastric, or pan…

This phase 2 trial tests whether specially selected immune cells taken from a patient's own tumor, grown in large numbers in the lab, and given back along with the drug pembrolizumab (Keytruda) can shrink tumors in people with metastatic colorectal, pancreatic, ovarian, breast, o…

This early-phase study tests CBX-12 in about 35 adults with advanced solid tumors that have spread and stopped responding to prior treatments. CBX-12 works by entering cancer cells and damaging their DNA, which can kill the cells. Researchers will measure how well the drug trigge…

This trial tests a new type of cell therapy for people with solid tumors that have spread to the lining of the chest, abdomen, or brain. The treatment uses a patient's own immune cells, engineered to recognize and attack cancer cells through two different targets. The goal is to …

This phase II trial is testing whether the combination of cabozantinib (a targeted therapy) and nivolumab (an immunotherapy) can shrink or stabilize advanced melanoma and head and neck cancers that have stopped responding to prior immunotherapy. Researchers are also checking if t…

This phase II trial tests whether a combination of amivantamab and hyaluronidase works as well as cetuximab for treating skin squamous cell carcinoma that has come back or spread. The study enrolls 86 immunocompromised participants, including organ transplant recipients. The goal…

This study tests an experimental drug called HRX215 in people who had part of their liver removed because colon cancer spread there. The drug is meant to help the liver grow back and work better after surgery. About 80 adults will take either HRX215 or a placebo for 28 days, and …

This early-phase study tests a new treatment called MQ710, a modified virus injected directly into tumors, alone or with the immunotherapy drug pembrolizumab. It is for people with advanced solid tumors (like skin cancer or head and neck cancer) that have not responded to standar…

This early-phase study tests a new drug called BH3120, alone or with pembrolizumab, in adults with advanced solid tumors that have stopped responding to standard treatments. The main goals are to check safety, find the best dose, and see if the drug can shrink tumors. About 245 p…

This early-phase study tests a new drug called DS-3939a in about 540 people with advanced solid tumors that have spread or cannot be removed. The main goals are to check safety and see if the drug shrinks tumors. Participants must have measurable disease and good organ function.

This early-phase trial tests MGC026, a biologic drug given by IV, in 250 adults with advanced solid tumors that have not responded to standard treatments. The study has two parts: first, finding a safe dose, then expanding to see if the drug shrinks tumors. Participants receive u…

This phase II trial is testing whether an anti-viral drug called valganciclovir (Valcyte) can help treat breast cancer that has spread to the brain. The study includes 28 adults with progressive brain metastases who also have evidence of a common virus called CMV. Participants ta…

This early-phase trial tests a new drug called BGB-B455 in about 90 people with advanced or metastatic solid tumors that have a specific protein (CLDN6). The main goals are to find a safe dose and see what side effects occur. The study has two parts: first finding the right dose,…

This study tests a device that uses both freezing and heating to destroy liver tumors in people with liver cancer or colorectal cancer that has spread to the liver. The goal is to see if this approach improves how long patients live without their cancer growing, and whether it ac…

This early-stage trial tests an experimental oral drug called SHY-ONC6 in people with advanced or metastatic solid tumors (including breast, colon, lung, pancreatic, and others) that have stopped responding to standard treatments. The study aims to find a safe dose and check for …

This early-phase trial tests a combination of two drugs—DS-8201a and olaparib—in people with advanced HER2-expressing cancers that have spread or cannot be removed. DS-8201a delivers chemotherapy directly to HER2-positive tumor cells, while olaparib blocks DNA repair in cancer ce…

This trial is testing a new drug called DS1025a in people with advanced solid tumors that have spread, cannot be removed by surgery, or have stopped responding to other treatments. The main goals are to check the drug's safety, how the body processes it, and whether it shows any …

This study tests a procedure called pulmonary suffusion, which delivers the chemotherapy drug cisplatin directly to the lungs through a minimally invasive method. The goal is to control any remaining cancer cells after surgery or ablation in patients with sarcoma or colorectal ca…

This early-stage trial tests the safety and best dose of two oral drugs, ZEN003694 and binimetinib, taken together. It is for people with advanced solid tumors that have RAS pathway changes or triple-negative breast cancer that has spread or cannot be removed. The goal is to find…

This study tests a new drug called rezatapopt (PC14586) in people with advanced solid tumors that have a specific TP53 Y220C mutation. The drug is designed to reactivate the p53 protein, which normally helps stop cancer growth. The trial will also test rezatapopt combined with th…

This trial is for people with a specific type of lung cancer (EGFR-mutant non-small cell lung cancer) that has spread to the lining of the brain and spinal cord (leptomeningeal metastasis) and has stopped responding to third-generation targeted pills. The study tests whether a pe…

This early-stage trial tests a new drug called GAIA-102 in children whose neuroblastoma or other solid tumors have not responded to standard treatments. The study has four groups, testing GAIA-102 alone or combined with other cancer drugs. The main goal is to check safety and fin…

This study tests a new drug, LY4050784, in people with advanced solid tumors that have a specific change in the SMARCA4 gene. The goal is to see if the drug is safe and works, either alone or with other cancer treatments. About 340 adults whose cancer has not responded to standar…

This study tests whether adding a new drug (LY4064809) to standard hormone therapy and CDK4/6 inhibitors can better control advanced HR+ HER2- breast cancer with a PIK3CA mutation. About 920 adults who have not had prior treatment for advanced disease will participate. The goal i…

This large Phase 3 study tests a new medicine called Sofetabart Mipitecan for people with ovarian, fallopian tube, or peritoneal cancer. It includes two groups: those whose cancer stopped responding to platinum chemotherapy within six months (platinum-resistant), and those whose …

This study tests whether giving focused radiation (radiosurgery) before surgically removing brain metastases can prevent the tumors from coming back. About 36 adults with 1 to 4 brain metastases will receive radiosurgery followed by surgery. Researchers will also monitor side eff…

This study tests a new drug, LY4257496, that delivers radiation directly to cancer cells with a specific protein (GRPR). It is for adults with advanced solid tumors like breast, prostate, or colorectal cancer that have not responded to other treatments. The goal is to see if the …

This early-phase trial tests the safety and best dose of two drugs—neratinib and trastuzumab deruxtecan—given together to people with advanced solid tumors that have HER2 gene changes. The goal is to see if the combination can shrink tumors that have spread or can't be removed by…

This study tests a drug called ifinatamab deruxtecan (I-DXd) in people with 13 types of advanced solid tumors that have come back or spread. The trial aims to see how well the drug shrinks tumors and what side effects it causes. About 520 participants will receive the drug intrav…

This study tests a new drug called AVZO-103 in people with advanced bladder cancer or other solid tumors that have spread. The drug is designed to seek out and attack cancer cells while sparing healthy ones. The trial will enroll about 355 adults and is the first time this drug i…

This early-stage trial tests a new drug called LY4052031, which is designed to deliver a cancer-killing agent directly to tumor cells that have a protein called Nectin-4. The study includes 420 adults with advanced or metastatic solid tumors such as bladder, breast, lung, and oth…

This study tests whether adding cetuximab to standard immunotherapy (pembrolizumab) helps people with advanced head and neck cancer that has stopped responding to platinum chemotherapy live longer. About 158 adults with cancer that has returned or spread will receive either pembr…

This phase 3 trial is testing whether adding a chemotherapy pump that delivers drugs directly to the liver (hepatic arterial infusion, or HAI) can help people with colorectal cancer that has spread to the liver and cannot be removed by surgery. About 408 participants will receive…

This early-phase study tests a new experimental drug (BI 3819026) alone and with another drug (ezabenlimab) in adults with advanced solid cancers that have not responded to standard treatments. The main goal is to find the safest dose and check for side effects. About 60 particip…

This trial is testing whether combining two drugs—amivantamab given intravenously and pemetrexed injected directly into the spinal fluid—can safely help people with a specific type of lung cancer that has spread to the membranes around the brain and spinal cord. This condition, c…

This pilot study explores whether people with melanoma or non-small cell lung cancer that has spread to the brain can safely skip stereotactic radiosurgery (focused radiation) after having a brain tumor surgically removed. Instead of radiation, participants receive systemic thera…

This early-stage trial tests a technique called PIPAC, which turns chemotherapy into a fine mist and sprays it directly into the abdomen during a keyhole surgery. The goal is to see if this method is safe and reduces side effects for people with biliary tract cancer that has spre…

This early-phase study tests a new drug (PLN-101095) alone or with pembrolizumab in adults whose advanced solid tumors have stopped responding to standard immunotherapy. About 124 participants will receive the treatment to check safety and early signs of tumor shrinkage. The goal…

This trial investigates the safest and most effective dose of fractionated stereotactic radiation therapy (FSRT) for people with large brain metastases (tumors that have spread from other cancers). Participants receive radiation in several small doses over 1.5 to 2 weeks. The stu…

This study tests whether combining experimental RAS(ON) inhibitors with ivonescimab (an immunotherapy) can shrink or control advanced solid tumors that have a RAS mutation. About 370 adults with cancers like non-small cell lung cancer or colorectal cancer will receive these drugs…

This early-phase trial tests an antibiotic called novobiocin in people with advanced solid tumors that have specific DNA repair mutations (like BRCA). The drug blocks a protein cancer cells use to fix their damaged DNA, which may cause them to die. The study aims to find the safe…

This study tests a drug called tarlatamab in 35 adults with small cell lung cancer that has spread to the brain but is not causing symptoms. The goal is to see if the drug can shrink or control these brain tumors. Participants must have already had standard chemotherapy and be in…

This phase 2 trial tests a drug called BMS-986504 in people with advanced solid tumors that have lost a gene called MTAP. The drug is given alone or with other cancer medicines. The study aims to see if the drug shrinks tumors and how safe it is. About 260 adults will take part.

This phase 2 trial is testing a combination of three therapies—modified immune cells (PD-L1 t-haNK), an immune-boosting protein (NAI/Anktiva), and a targeted antibody (cetuximab)—in 25 people with recurrent or metastatic head and neck cancer that has not responded to prior immuno…

This early-stage trial tests whether a specially engineered herpes virus (G207) is safe to inject directly into the brain tumors of children whose cancer has returned. Up to 24 children aged 3 to 21 will receive the virus, and some will also get a small dose of radiation to help …

This phase II trial is testing whether continuing targeted therapy or immunotherapy based on a tumor's molecular profile can benefit patients with advanced solid tumors that have stopped responding to prior treatment. After an initial treatment period, patients whose disease is s…

This phase II trial tests a special way of delivering whole-brain radiation called pulsed reduced dose-rate (PRDR) along with the drug memantine to help protect memory and thinking in people with brain metastases. About 53 adults with solid tumors that have spread to the brain wi…

This early-phase study tests an experimental drug called ZE94-0605 in about 60 adults with advanced solid tumors that have not responded to standard treatments. The main goals are to find a safe dose and check for any signs of tumor shrinkage. The study is not yet recruiting.

This study tests an experimental drug called IDP-001 in people with advanced or metastatic solid tumors, including certain lung, head and neck, and other cancers. The trial has two phases: first to check safety and find the right dose, then to see if the drug can shrink tumors. A…

This trial is testing an experimental drug called petosemtamab (MCLA-158) in people with advanced solid tumors, including colorectal, head and neck, and lung cancers. The drug is a bispecific antibody designed to block two cancer-related proteins, EGFR and LGR5. Researchers want …

This trial is testing whether giving radiation in two separate doses works better than a single high dose for people with cancer that has spread to the spine. The goal is to see which approach controls tumor growth longer while keeping side effects low. About 274 adults with up t…

This phase 2 trial tests a new drug called zanzalintinib, taken as a pill, combined with a bone-strengthening agent for people with advanced kidney cancer that has spread to the bones. The study enrolls 20 participants whose cancer has worsened after 1–3 prior treatments, includi…

This early-stage trial is testing a new drug called IBI3028 in people with advanced solid tumors that cannot be removed by surgery or have spread. The drug works by attaching to two proteins (EGFR and c-Met) found on some cancer cells and delivering two anti-cancer agents directl…

This phase 2 trial tests whether adding the drug narlumosbart and precise radiation therapy to standard first-line treatment can help people with advanced non-small cell lung cancer that has spread to the bones. The study will enroll 27 adults who have not had prior systemic ther…

This study tests whether a focused ultrasound device can safely open the blood-brain barrier in people with non-small cell lung cancer that has spread to the brain. About 30 participants will receive standard immunotherapy plus the ultrasound procedure. The goal is to see if this…

This phase II trial tests whether giving focused, high-dose radiation (SABR) to a small number of growing tumors, while continuing the same systemic therapy, can delay overall cancer progression in people with metastatic cancer. About 46 patients whose cancer has started to progr…

This phase II trial tests whether injecting two chemotherapy drugs—thiotepa and methotrexate—directly into the spinal fluid can shrink or control breast cancer that has spread to the leptomeninges (the lining of the brain and spinal cord). Participants receive the drugs through a…

This study tests a new way to plan brain tumor surgery by creating detailed maps of each patient's brain networks using advanced MRI. Instead of relying only on standard anatomy, surgeons can see the white matter pathways and functional networks that could be affected. The goal i…

This phase IIa trial tests a combination of a dendritic cell vaccine (targeting HER2/HER3 proteins) and the immunotherapy drug pembrolizumab (Keytruda) in 23 women with breast cancer that has spread to the brain. The vaccine aims to train the immune system to attack cancer cells,…

This early-phase trial tests a new drug called STC-15, either alone or combined with an immunotherapy drug (toripalimab), in people with advanced solid tumors or certain sarcomas. The study aims to check safety and whether the drugs shrink tumors. About 107 participants will be e…

This study tests an experimental treatment called OBX-115 for people with advanced melanoma or non-small cell lung cancer that has spread or stopped responding to standard therapy. OBX-115 uses a patient's own immune cells (tumor-infiltrating lymphocytes) that are modified in the…

This study tests an oral drug called NEO212 in people with specific brain tumors (astrocytoma, glioblastoma) or cancers that have spread to the brain. The goal is to find the safest dose and see if it helps control tumor growth. About 134 adults will take NEO212 alone or with sta…

This phase 2 trial tests whether two drugs, tucatinib and T-DM1, can control HER2-positive solid tumors that have spread to the brain. About 30 participants will receive both drugs, and researchers will monitor side effects and how well the treatment works. The goal is to find a …

This early-phase trial tests a wearable device that creates electric fields (tumor treating fields) combined with either cabozantinib or nab-paclitaxel and atezolizumab in 43 people with advanced solid tumors in the abdomen or chest. The goal is to find the safest dose and see if…

This trial compares two surgical methods for reattaching the hip abductor muscles after proximal femur replacement, a surgery often needed for bone cancer or metastases. The goal is to see which method leads to better walking and hip function. Researchers will also test a simple …

This phase 1 trial tests an experimental drug called ACM-CpG, given as a shot into the muscle, in people with advanced solid tumors that have not responded to standard immunotherapy. The drug is designed to activate the immune system to attack tumors. The study aims to find the s…

This early-phase study tests a new mRNA-based treatment for people with advanced solid tumors that have not responded to standard therapies. The treatment aims to control tumor growth by delivering a specific protein (IL-22BP) using a peptide carrier. The main goals are to check …

This early-phase trial tests whether deferoxamine, a drug given directly into the spinal fluid, is safe for people with leptomeningeal metastases—cancer that has spread to the lining of the brain and spinal cord. Researchers will test different doses in 35 adults with solid tumor…

This study compares bevacizumab (Avastin) to standard steroid treatment (dexamethasone) as the first therapy for people with brain radiation necrosis—a side effect of radiation therapy for brain tumors. About 408 participants with high-grade glioma or brain metastases will be ran…

This early-phase trial tests the safety and best dose of a new drug combination—pidnarulex plus trastuzumab deruxtecan—in people with advanced breast cancer and other solid tumors that have the HER2 protein. The study enrolls 36 adults whose cancer has spread or cannot be surgica…

This study looks at different ways to perform a liver transplant in people whose colorectal cancer has spread to the liver and cannot be removed by surgery. Researchers will compare living versus deceased donor transplants, whole versus split organs, and one-stage versus two-stag…

This study tests a dendritic cell vaccine given directly into the spinal fluid for people with breast cancer that has spread to the lining of the brain and spinal cord (leptomeningeal disease). The vaccine is combined with either trastuzumab (for HER2-positive cancer) or nivoluma…

This phase 2 trial tests belvarafenib, a daily pill that targets cancers with a BRAF mutation, in people with primary or metastatic brain tumors. Participants take the drug for about six months, and doctors monitor tumor response with scans. The goal is to see if the drug can con…

This early-phase trial tests whether combining three drugs—axatilimab, retifanlimab, and paclitaxel—is safe and effective for people with advanced or metastatic solid tumors. The study will enroll 38 adults whose cancer has spread or not responded to prior treatment. Researchers …

This trial looks at whether surgically removing the primary lung tumor can help people with M1a stage lung cancer, where cancer cells are found in the chest lining during surgery. The study includes 66 adults aged 18–80 who have not had prior lung cancer treatment. Researchers wi…

This study is testing an experimental oral drug called ATX-295 in people with advanced solid tumors, including ovarian cancer, that have not responded to standard treatments. The main goal is to find a safe and tolerable dose and to see if the drug can shrink tumors. About 90 par…

This study tests a high dose of the chemotherapy drug methotrexate given through a vein in people with breast cancer that has spread to the lining of the brain. The goal is to see if it helps them live longer. The trial includes adults with triple-negative, HER2-positive, or horm…

This early-stage trial tests a new drug called HLX48 in 72 people with advanced or metastatic solid tumors that have not responded to standard treatments. HLX48 is designed to target two cancer-related proteins (EGFR and c-MET) and deliver a toxic payload directly to cancer cells…

This early-stage trial tests whether giving a higher dose of focused radiation (stereotactic radiosurgery) to brain metastases is safe. About 50 people with 1 to 5 brain tumors who have never had brain radiation will receive an experimental dose on one tumor, while other tumors g…

This study compares two radiotherapy schedules for men whose prostate cancer has returned after surgery. The standard treatment takes 5 weeks, while the shorter one takes 4 weeks. Researchers want to see if the shorter schedule causes no more side effects and controls the cancer …

This trial tests a precise type of radiation called SABR on all visible tumors in people with 11 or more metastases. Participants are randomly assigned to either standard palliative radiation or SABR to every tumor. The goal is to see if this aggressive approach improves overall …

This study tests a personalized vaccine made from a patient's own tumor proteins, given alone or with the immunotherapy drug pembrolizumab. The goal is to see if the combination is safe and helps the immune system attack advanced solid tumors. About 132 people with various advanc…

This study tests whether removing as much tumor as possible through surgery before giving a targeted radioactive drug (Lutetium Lu 177 dotatate) works better for people with slow-growing neuroendocrine tumors that have spread to the liver. Six adults with grade 1 or 2 tumors will…

This study tests whether adding AGuIX gadolinium-based nanoparticles to standard brain radiation can better control brain metastases that are at high risk of coming back. About 134 adults with certain cancers (like melanoma, lung, breast, or colorectal) that have spread to the br…

This study is for people whose brain metastases have come back or caused radiation damage after initial treatment. It compares a laser-based procedure (LITT) plus standard care against standard care alone (steroids or repeat radiation). The goal is to see if LITT can better contr…

This early-stage trial is testing whether combining two drugs—niraparib and irinotecan—can safely treat advanced solid tumors that have mutations in DNA repair genes like BRCA. The study will enroll 24 adults with various cancers, including breast, ovarian, pancreatic, and others…

This study tests whether combining radiation therapy with three drugs (platinum chemotherapy, adebrelimab, and bevacizumab) can control brain metastases from triple-negative breast cancer. About 58 adults aged 18-70 with this specific type of advanced breast cancer will receive t…

This study tests whether adding the experimental drug CGT9486 to the standard drug sunitinib helps people with advanced GIST live longer without their cancer growing. About 482 adults with GIST that cannot be removed by surgery or has spread will take part. The goal is to see if …

This phase 2 trial is testing three different drugs—abiraterone acetate, enzalutamide, and apalutamide—in 192 veterans with castrate-sensitive prostate cancer that has spread. The goal is to see which drug works best as a first treatment when combined with hormone therapy. Resear…

This phase 1 trial tests a new therapy called MSK-TCR5 for people with advanced solid tumors that have a specific genetic change (RAS G12D mutation) and a certain immune type (HLA-A*11:01). The therapy uses a patient's own T-cells, modified in a lab to better recognize and attack…

This study tests whether adding targeted radiation to immunotherapy can help control advanced non-small cell lung cancer better than standard chemotherapy. It is for patients whose cancer has worsened after previous immunotherapy. About 39 adults will be randomly assigned to one …

This study looks at whether giving focused radiation before or after surgery works better for people with brain tumors that started elsewhere in the body. About 140 adults with one brain tumor that can be removed will be randomly assigned to get radiation either before or after s…

This early-phase trial is testing a new treatment called MEM-288, a virus designed to infect and kill cancer cells while also boosting the immune system. The study involves 40 adults with advanced solid tumors, including lung, skin, and breast cancers, who have not responded to s…

This study tests an experimental drug called YH32364 in adults with advanced solid tumors that have high levels of EGFR and have not responded to previous treatments. The trial has two parts: first, finding a safe dose in about 30 people, then testing that dose in 50 people with …

This study tests a new experimental drug called PLX-61639 for people with advanced solid tumors that have a specific genetic change (SMARCA4 mutation) and have stopped responding to standard treatments. The drug is taken as a daily pill and aims to shrink or control the cancer. A…

This study is for people with stage IV cancer that has started to grow in only a few places (oligoprogression). It compares adding local treatments like radiation or surgery to all growing spots versus switching to a new systemic therapy. The goal is to see if this approach can b…

This early-phase study tests a new drug, ASP2998, that targets a protein called TROP2 found on many solid tumors. The drug is given alone or with standard treatments like pembrolizumab or carboplatin. The main goals are to check safety and find the right dose. About 428 adults wi…

This study looks at whether adding a new anti-tumor drug to standard radiation therapy can help control advanced breast cancer that has spread to the brain. About 100 adults with this condition will be observed to see how long the cancer stays under control and if the treatment i…

This phase II trial is testing the drug pemetrexed in people with advanced bladder cancer or other solid tumors that have spread and carry certain gene mutations (MLL4, UTX, or MTAP). The goal is to see if pemetrexed can shrink tumors. About 64 participants will receive the drug …

This study looks at whether getting standard immunotherapy in the morning (before 11 am) or afternoon (after 12 pm) changes how well it fights advanced or metastatic solid tumors. Researchers think the body's internal clock (circadian rhythm) might affect immune activity. About 1…

This study tests whether adding the drug olutasidenib to standard chemotherapy (temozolomide) can help children and young adults with a specific type of brain cancer (IDH1-mutant high-grade glioma) live longer. About 60 participants will receive the combination as maintenance the…

This study tests a new immunotherapy for people with advanced HPV-related cancers, such as cervical, throat, anal, and penile cancers. Participants receive specially engineered immune cells designed to attack cancer cells carrying the HPV16 virus. The goal is to see if this treat…

This study tests a new treatment using specially engineered natural killer (NK) cells to attack advanced lung cancer that has spread. About 60 adults whose tumors have certain markers will receive chemotherapy followed by an infusion of these cells. The goal is to find a safe dos…

This phase 2 trial tests the drug avapritinib in 50 adults with advanced solid tumors that have mutations in the CKIT or PDGFRA genes. The drug blocks enzymes that help cancer cells grow. The main goal is to see how many patients' tumors shrink or disappear. Researchers will also…

This early-phase study is testing whether a dietary supplement called zeaxanthin, taken alone or with the immunotherapy drug pembrolizumab, is safe for people with advanced solid tumors that have not responded to standard treatments. The trial will enroll 72 participants to find …

This study tests two different chemotherapy combinations for people with metastatic colorectal cancer that has spread and needs a second treatment. About 280 adults will be randomly assigned to receive either FOLFIRI or irinotecan, with or without bevacizumab. The goal is to see …

This early-phase trial is testing a new type of cell therapy for people with advanced pancreatic cancer that has spread or cannot be removed by surgery. The treatment uses specially engineered natural killer (NK) cells that target two proteins found on cancer cells. Up to 42 part…

This study tests an experimental drug called NEOK002 in people with advanced solid tumors that have spread and cannot be removed by surgery. The drug is designed to target two proteins on cancer cells to deliver a toxic payload. The study has two parts: first, finding the safest …

This study tests whether a combination of two drugs, sacituzumab tirumotecan and bevacizumab, can shrink or control brain tumors in people with triple-negative breast cancer that has spread to the brain. About 24 adults whose cancer cannot be removed by surgery or radiation will …

This early-stage trial is testing the drug sacituzumab govitecan in 30 people with advanced solid tumors who also have moderate liver impairment. The main goal is to find a safe starting dose by monitoring side effects and how the drug moves through the body. Participants receive…

This early-phase study tests a new radioactive drug (BRP-020063) in 10 people with advanced solid tumors that have spread. The drug is used first for imaging to find tumors, then a low dose is given to see if it's safe and how it travels in the body. The goal is to gather informa…

This study combines two treatments—laser heat to destroy tumors near the spinal cord and precise radiation—to better control spine tumors that have spread from other cancers. About 60 adults with solid tumors will receive both therapies. The goal is to improve tumor control, redu…

This study tests an experimental drug called INV-6452 in adults with advanced breast cancer (HR+/HER2-) or other solid tumors that have stopped responding to standard treatments. The goal is to find the safest dose and see if the drug can shrink tumors. About 201 participants wil…

This study tests a new drug called HRS-6719 in people with advanced solid tumors that lack a gene called MTAP. The trial has two phases: first to find the safest dose, then to see if it shrinks tumors. About 120 participants will take part across multiple centers.

This early-stage trial tests whether adding a chemotherapy drug (5-Azacitidine) to standard immunotherapy can help patients whose solid tumors have stopped responding to PD-1/PD-L1 inhibitors. About 35 adults with advanced or metastatic cancers will receive the combination to fin…

This early-stage trial tests a new drug called HLX316 in people with advanced solid tumors that have not responded to standard treatments. The drug is designed to help the immune system attack cancer cells. The study will check for safety, side effects, and whether the drug can s…

This early-phase trial tests a new drug called NEOK001 in people with advanced solid tumors that have stopped responding to standard treatments. NEOK001 is designed to deliver a cancer-killing agent directly to tumor cells by targeting two specific proteins. The study will first …

This study tests a new drug called repotrectinib in people with advanced solid tumors that have certain gene changes (ALK, ROS1, or NTRK). The trial has two parts: first, finding a safe dose, and second, seeing how well the drug shrinks tumors. About 500 adults with advanced canc…

This early-phase trial is testing a new drug called KK2260 in people with advanced solid tumors that have not responded to standard treatments. The study will first find the safest dose, then test different dosing schedules in patients with esophageal or head and neck cancers. Ab…

This study tests whether people with brain metastases from solid tumors can avoid radiation therapy if their brain tumors shrink or stay stable with systemic treatments like immunotherapy, targeted therapy, or chemotherapy. About 45 participants will be monitored with regular bra…

This early-stage trial is testing whether the drug sotorasib can get into KRAS G12C+ brain tumors and how safe and effective it is. Sixteen adults with these tumors who are already scheduled for brain surgery will receive the drug. Researchers will measure how much drug reaches t…

This study is for women with advanced ovarian, fallopian tube, or peritoneal cancer whose tumors did not shrink enough with standard chemotherapy. Researchers are testing a new method called PIPAC, which delivers chemotherapy as a pressurized spray directly into the abdomen, comb…

This study tests whether a 4-week ketogenic diet before liver surgery can reduce fat in the liver and lower the need for blood transfusions. About 124 adults with fatty liver and colorectal cancer that spread to the liver will either follow the diet or get standard dietary advice…

This Phase 2 trial tests whether adding the experimental drug givastomig to standard immunotherapy and chemotherapy can help people with advanced stomach or esophageal cancer live longer without their cancer growing. About 180 adults whose tumors have certain proteins (CLDN18.2 a…

This study tests a new treatment called EB-NK-301, which uses specially engineered immune cells (CAR NK cells) to target a protein called TROP2 found on many solid tumors. The trial enrolls 60 adults with advanced or metastatic cancers that have not responded to standard treatmen…

This study is testing whether a lower dose of radiation can effectively treat metastatic tumors that have a specific genetic change called an ATM mutation. The goal is to find the smallest effective dose to reduce side effects. About 45 adults with advanced cancer and an ATM muta…

This study tests whether injecting a PD-1 inhibitor (tislelizumab or pembrolizumab) plus pemetrexed directly into the spinal fluid can help people with non-small cell lung cancer that has spread to the lining of the brain (leptomeningeal metastases). The trial will enroll 17 adul…

This phase 2 trial is testing a new drug, trastuzumab rezetecan, against an existing drug, trastuzumab deruxtecan, in 150 women with a common type of advanced breast cancer (HR-positive, HER2-low). The goal is to see which dose works best to slow cancer growth. Participants must …

This early-phase study is testing whether a combination of low-dose radiation to the whole brain, an immunotherapy drug (PD-1 inhibitor), and chemotherapy given directly into the spinal fluid can safely treat lung cancer that has spread to the lining of the brain and spinal cord.…

This early-stage trial tests a combination of low dose radiotherapy, focused radiation (SBRT), and the immunotherapy drug tislelizumab in people with large solid tumors that have not responded to standard treatments. The study aims to see if this approach is safe and tolerable. A…

This study tests whether giving focused radiation before surgery for large brain metastases works better than giving it after surgery. About 146 adults with solid tumors and one large brain metastasis will be randomly assigned to one of the two timing schedules. The main goal is …

This early-phase trial tests whether injecting methotrexate-loaded vesicles (tiny drug-carrying particles made from patients' own tumor cells) into the spinal fluid can safely treat lung cancer that has spread to the brain lining. About 14 adults who have failed standard treatmen…

This study compares two ways of giving the chemotherapy drug 5-FU to people with head and neck cancer that has spread or come back after prior treatments. One group gets the drug over two days every two weeks, the other over four days every three weeks. The goal is to see which s…

This study compares two ways to prevent brain tumors from growing back after surgery. One group gets a chemotherapy wafer (GLIADEL) placed directly where the tumor was removed, while the other group receives radiation treatment within six weeks. The trial aims to see if the wafer…

This early-stage study tests a two-part system to find and treat metastatic cancer. First, a radioactive tracer is used to spot tumors on a PET scan. Then, a similar radioactive drug is given to deliver radiation directly to the cancer cells. The goal is to see if this approach i…

This pilot study is testing a precise form of radiation called proton SBRT for people with cancer that has spread to the spine and cannot be treated effectively with standard photon radiation. The study will enroll 12 participants and aims to see if the treatment can be delivered…

This early-phase study tests a new drug called DR30206 in about 216 adults with advanced or metastatic solid tumors who have no other treatment options. The main goals are to check the drug's safety, find the best dose, and see if it can shrink tumors. Participants will receive t…

This study tests a new treatment using natural killer (NK) cells, a type of immune cell, for adults with aggressive brain tumors that have not responded to standard therapies. The NK cells are grown in a lab and then given through a vein and directly into the brain. The main goal…

This study is for people with endometrial cancer that has come back or spread to a few other spots. It tests a new drug called cadonilimab given together with standard chemotherapy and radiation. The goal is to see if this combination can shrink tumors and help people live longer…

This early-stage trial tests a new drug called KGX101, given alone or with another immunotherapy (envafolimab), in people with advanced or metastatic solid tumors that have not responded to standard treatments. The main goals are to check safety and find the best dose. About 57 p…

This early-phase study is testing a new drug called JZP815 in people with advanced or spreading solid tumors that have specific changes in the MAPK pathway. The main goals are to check the drug's safety, find the right dose, and see if it can shrink tumors. About 332 adults who h…

This study tests a higher dose of a targeted therapy (EGFR-TKI) combined with two other drugs for people with advanced lung cancer that has spread to the lining of the brain and worsened on standard treatment. About 30 participants will receive the triple combination to see if it…

This study tests whether precise, high-dose radiation (stereotactic radiotherapy) can restore the effectiveness of anti-PD1 immunotherapy in patients with metastatic solid tumors. Participants are those who initially responded well to immunotherapy for at least 6 months but then …

This study tests whether using a smaller, more precise radiation target for spinal tumors can control cancer just as well as treating the whole vertebra. One hundred adults with spine metastases will be randomly assigned to standard or smaller-target radiation. The goal is to see…

This study tests whether two drugs, zanzalintinib and pembrolizumab, can help control advanced soft-tissue sarcoma that has spread. About 20 adults with specific sarcoma types will receive the combination. The main goal is to check safety and see if the treatment slows tumor grow…

This phase 2 trial tests the drug IMC-001 in 30 adults with advanced solid tumors that have a high number of genetic mutations (TMB-H). Participants receive the drug by IV every two weeks. The main goal is to see if the drug shrinks tumors. Researchers will also monitor side effe…

This early-phase study tests a personalized treatment called GT101 for adults with advanced solid tumors that have spread or come back. Doctors take immune cells from the patient's own tumor, grow them in a lab, and infuse them back after mild chemotherapy. The goal is to see if …

This early-stage trial is testing a new drug called ATG-022 in people with advanced or metastatic solid tumors that have not responded to standard treatments. The main goal is to find a safe dose and check for side effects. Up to 156 participants will receive the drug every three…

This study tests two drugs, abemaciclib and bicalutamide, together in people with a type of metastatic breast cancer that has spread and is positive for androgen receptors but negative for HER2. The goal is to find the safest dose and see if the combination can control the diseas…

This study tests whether giving radiation in one session or several sessions works better for people whose cancer has spread to the brain. About 90 adults with brain tumors between 2 and 4 cm will be randomly assigned to one of two radiation approaches. The goal is to see which m…

This early-phase trial is testing a new approach to CAR-T cell therapy for adults with advanced solid tumors that have not responded to standard treatments. The therapy uses a patient's own immune cells, engineered to recognize two cancer-specific targets chosen based on each per…

This study tests a treatment called electrochemotherapy for people with tumors in organs like the liver or pancreas that cannot be removed by surgery. The treatment uses short electrical pulses to help chemotherapy drugs enter cancer cells more effectively. The goal is to shrink …

This study is for people with cancer that has spread to the spine. It tests whether adding a procedure called vertebroplasty (which repairs broken spine bones) to standard radiation and immunotherapy can help prevent fractures and improve survival. About 200 participants will rec…

This study tests a new way to treat stomach cancer that has spread to the lining of the belly. Doctors will use a robot to remove visible cancer and then deliver heated chemotherapy directly into the abdomen during surgery. The goal is to help patients recover faster and have few…

This phase III trial tests whether adding nitroglycerin patches to standard radiation therapy helps shrink brain tumors better than radiation alone in people with a specific type of lung cancer (EGFR-mutant non-small cell lung cancer). 74 participants will receive either radiatio…

This study tests a new treatment using donor immune cells (CAR-NK cells) that are engineered to recognize and attack cancer. The treatment is personalized based on a tumor's unique markers. It is for adults with advanced solid tumors that have not responded to other therapies. Th…

This trial is testing a new approach for people with head and neck cancer that has come back or spread and cannot be removed. It combines a device called DaRT, which is a tiny radioactive seed placed directly into the tumor, with the immunotherapy drug pembrolizumab (Keytruda). T…

This phase 2 trial tests whether adding a chemotherapy drug (thiotepa) directly into the spinal fluid can prevent glioblastoma from spreading to the brain and spinal cord lining. The study enrolls 38 newly diagnosed patients whose tumors touch brain fluid spaces or whose surgery …

This phase 3 trial tests two ways to treat lung cancer that has spread to the brain. One group gets targeted radiation to each tumor plus a drug (bevacizumab) that starves tumors of blood. The other group gets whole-brain radiation that tries to avoid the memory centers. The stud…

This early-stage trial tests a new mRNA vaccine called ABO2102, designed to target cancers with specific KRAS mutations. About 101 adults with advanced solid tumors will receive the vaccine alone or with another drug (Sintilimab). The study focuses on safety and how the body resp…

This early-phase trial is testing an investigational drug called SYS6043 in adults with advanced or metastatic solid tumors that have spread or no longer respond to standard treatments. The study aims to find a safe dose and watch for side effects, while also looking for early si…

This trial is testing a higher, every-other-day dose of the drug furmonertinib in people with a specific type of lung cancer (EGFR-mutant NSCLC) that has spread to the lining of the brain and spinal cord (leptomeningeal metastasis). The study will compare this high-dose schedule …

This study is for people with metastatic breast cancer that has spread to the brain, with at least two brain tumors. Participants receive an immunotherapy drug called pembrolizumab every three weeks, plus a precise, one-time radiation treatment to just one of the brain tumors. Th…

This early-phase trial tests an experimental drug called HMPL-A580 in 186 adults with advanced or metastatic solid tumors that cannot be removed by surgery. The study aims to find a safe dose and check for early signs that the drug shrinks tumors. It is currently recruiting parti…

This early-stage trial is testing a new daily oral medication called ETX-19477 in about 120 adults with advanced solid tumors, including breast, ovarian, prostate, and other cancers. The drug blocks a protein called PARG to interfere with cancer cells' ability to repair themselve…

This phase 2 trial tests a combination of pemetrexed (given into the spinal fluid) and a tyrosine kinase inhibitor for people with a specific type of lung cancer (EGFR-mutant NSCLC) that has spread to the lining of the brain and spinal cord (leptomeningeal metastasis) after the d…

This early-phase trial tests CPO301, a drug designed to seek out and attack cancer cells that have a protein called EGFR on their surface. About 132 adults with advanced solid tumors (including lung, breast, and head & neck cancers) will receive the drug by IV every three weeks. …

This study is testing whether giving an extra 'boost' of radiation to spinal tumors that have spread from other cancers can better control the tumor, reduce pain, and limit side effects. The trial will enroll 108 adults with confirmed or suspected solid tumors that have spread to…

This study tests whether adding four drugs (gefitinib, trametinib, disulfiram, and sunitinib) to standard chemotherapy helps people with osteosarcoma that has spread. About 45 participants with newly diagnosed or advanced disease will be enrolled. Researchers will check if the co…

This early-phase trial is testing an experimental drug called INV-1120, either by itself or combined with the immunotherapy pembrolizumab (Keytruda), in adults with advanced solid tumors that have stopped responding to standard treatments. The main goals are to find safe doses an…

This early-phase study tests a new drug called CCI-001 in people with advanced solid tumors that have come back or spread. The main goals are to check the drug's safety and find the best dose. About 70 participants will receive CCI-001 alone or with standard chemotherapy drugs li…

This early-phase trial is testing a new drug called DCSZ11 alongside standard chemotherapy or immunotherapy in 9 people with advanced or metastatic solid tumors, including head and neck cancer. The main goal is to see if the combination is safe and whether it can shrink tumors. B…

This study is testing a bone marrow transplant from a half-matched family donor for people with high-risk solid tumors that have come back or not responded to treatment. Participants receive mild chemotherapy and radiation before the transplant, along with drugs to prevent reject…

This study compares two radiation therapies for people with 4 to 15 brain metastases from cancer: stereotactic radiosurgery (SRS), which is done in 1-2 sessions, versus whole-brain radiotherapy (WBRT), which takes 10 sessions. The goal is to see if SRS offers similar survival wit…

This study tests whether adding the drug sarilumab to chemotherapy (capecitabine) can eliminate tiny amounts of cancer left behind after standard treatment in people with triple negative breast cancer, a very aggressive type. The goal is to prevent the cancer from coming back and…

This study is for people whose brain metastases have returned after initial radiation. It combines either laser ablation or surgery with a second round of targeted radiation. The goal is to control the disease and monitor side effects in 155 participants.

This early-phase trial tests a personalized vaccine made from a patient's own tumor cells, given alone or with the immunotherapy drug pembrolizumab, for people with head and neck cancer that has returned or spread. The main goals are to check safety, find the best dose, and see i…

This early-stage study tests a new drug called tolododekin alfa (ANK-101) for people with advanced solid tumors that have not responded to standard treatments. The drug is injected directly into the tumor to see if it is safe and tolerable. About 97 adults with various solid canc…

This early-stage study tests an experimental drug called TJ033721 (givastomig) in people with advanced or metastatic solid tumors that have stopped responding to standard treatments. The main goals are to check the drug's safety, find the right dose, and see how the body processe…

This study tests whether giving a single dose of radiation before surgery for brain metastases can lower the chance of cancer spreading to the lining of the brain, compared to five doses after surgery. About 200 adults with brain tumors that can be removed will take part. The goa…

This study tests a new drug called JK06, designed to seek out and attack cancer cells while sparing healthy ones. It is for adults with advanced solid tumors that cannot be removed by surgery or have spread. The main goals are to find the safest dose and see if the drug can shrin…

This study tests a procedure called chemoembolization for people with non-small cell lung cancer or lung tumors that have spread from other cancers. Doctors inject chemotherapy directly into the artery feeding the tumor and then block that artery with tiny beads. This traps the c…

This early-phase trial is testing an investigational drug called risvutatug rezetecan in 15 people with recurrent glioblastoma or brain metastases. The drug is designed to seek out and deliver a cancer-killing payload to tumor cells. The study first measures how much drug gets in…

This phase 2 study is testing stereotactic body radiation therapy (SBRT) for people with non-small cell lung cancer or other cancers that have spread to the lung. Instead of daily radiation for weeks, participants receive high doses in just 3 to 10 sessions over 1 to 2 weeks. The…

This study is for people with metastatic melanoma whose cancer has started growing in a few spots despite treatment. Researchers want to see if giving high-dose, precise radiation to those spots can delay further spread. About 52 adults will take part, and the main goal is to see…

This early study tests whether injecting two cancer drugs (pemetrexed and bevacizumab) directly into the spinal fluid is safe for people with a specific type of lung cancer that has spread to the lining of the brain. The trial will enroll 19 adults whose cancer has worsened despi…

This pilot study tests whether giving precise, high-dose radiation to all visible tumors (up to 10) can improve the effectiveness of immunotherapy in people with advanced solid tumors that have spread. About 28 adults with 3-10 metastases will receive radiation over 3 weeks while…

This early-phase trial is testing MBRC-101, a drug that seeks out cancer cells and delivers a chemotherapy payload directly to them. It is for people with advanced solid tumors that have not responded to standard treatments. The study will first find the safest dose, then check f…

This early-phase study tests HLX37, a new drug that targets two cancer growth pathways (PD-L1 and VEGF) at once, in people with advanced solid tumors that have spread. The main goals are to check safety, find the right dose, and see how the drug behaves in the body. Up to 254 par…

This study is testing a highly precise radiation method called SBRT for people with cancer that has spread to the spine. The goal is to deliver strong radiation doses while protecting nearby healthy tissue. Researchers will track side effects and how well the treatment controls t…

This study is for people with HER2+ breast cancer that has spread to the lining of the brain and spinal cord (leptomeningeal disease). It combines targeted drugs (tucatinib, trastuzumab, capecitabine) with radiation to the brain or spine. The goal is to see if this approach helps…

This study tests a new drug called SYS6043 in people with advanced or metastatic solid tumors that have not responded to standard treatments. The drug is an antibody-drug conjugate designed to target and kill cancer cells. The trial will first find the safest dose, then expand to…

This study tests whether giving radiation early to spine tumors that are not yet painful can prevent serious problems like fractures or spinal cord compression. About 74 adults with cancer that has spread to the spine will receive radiation before symptoms get worse. The goal is …

This study tests a combination of three drugs (trastuzumab-deruxtecan, capecitabine, and bevacizumab) as a first treatment for people with HER-2 positive colorectal cancer that has spread or cannot be removed by surgery. The goal is to see how well the drugs shrink tumors. About …

This early-stage trial tests whether combining high-intensity focused ultrasound (HIFU) with immune checkpoint inhibitors (ipilimumab and nivolumab) is safe and feasible for people with metastatic or unresectable cancer that has worsened after standard treatments. 24 adults will …

This phase II trial tests whether adding lovastatin, a common cholesterol-lowering drug, to the immunotherapy pembrolizumab can help shrink tumors in people with head and neck cancer that has returned or spread. The study will enroll 28 adults whose tumors express PD-L1. Research…

This study tests a treatment using a patient's own immune cells (called tumor-infiltrating lymphocytes or TILs) combined with chemotherapy and interleukin-2 for people with advanced cutaneous squamous cell carcinoma or Merkel cell carcinoma who have already tried immunotherapy. T…

This early-stage trial tests AGX101, a drug that delivers chemotherapy directly to cancer cells by targeting a protein called TM4SF1. About 80 adults with advanced solid tumors (like breast, prostate, or pancreatic cancer) who have run out of standard options will receive the dru…

This early-stage trial tests whether a topical cream called diphencyprone (DPCP) can help standard immunotherapy work better in people with advanced cancer that has spread to the skin. About 100 participants will apply DPCP twice a week for 12 weeks alongside their usual PD-1 or …

This study is testing a drug called zorifertinib as the first treatment for people with advanced non-small cell lung cancer that has a specific gene mutation (EGFR) and has spread to the brain or spinal cord. The trial will enroll 800 participants and compare zorifertinib to othe…

This early-stage trial tests an experimental oral drug called CSCJC3456 in 102 people with advanced solid tumors that have not responded to standard treatments. The study aims to find a safe dose and check for any signs that the drug can shrink tumors. Participants take the table…

This phase 2 trial tests whether giving precise radiation (SBRT) to a few growing cancer spots can help women with ER+/HER2- metastatic breast cancer stay on their current hormone therapy or CDK4/6 inhibitor longer. The study enrolls 48 women whose cancer has started to progress …

This phase 3 trial tests whether treating 1 to 10 metastatic tumors right away with precise radiation improves survival compared to waiting 3 months. It includes 800 adults with lung, colorectal, or prostate cancer that has spread to a few spots. Participants are randomly assigne…

This study tests a chemotherapy drug called pemetrexed, given directly into the spinal fluid, for people with a specific type of lung cancer that has spread to the lining of the brain and spinal cord. The cancer must have gotten worse even after taking a high dose of a targeted t…

This early-stage trial tests the safety of a new drug called KK2269, given alone or with chemotherapy (docetaxel), in adults with advanced solid tumors that have no standard treatment options. About 101 participants will take part. The study has two parts: first testing KK2269 al…

This early-phase trial is testing a personalized vaccine made from a patient's own tumor, given alone or with immune-boosting drugs (pembrolizumab or ipilimumab), for triple negative breast cancer. The goal is to see if the vaccine is safe and can train the immune system to attac…

This early-phase study tests a new treatment called PTC13, which uses specially engineered immune cells (CAR-T cells) to attack cancer cells that have a protein called CEA. The study includes 18 adults with advanced colorectal, stomach, pancreatic, or other solid tumors that have…

This early-phase trial is testing an experimental drug called SIM0610 in 260 adults with advanced solid tumors, including lung, colorectal, head and neck, and liver cancers. The main goals are to check the drug's safety, find the right dose, and see if it shrinks tumors. Particip…

This study tests a new drug, FZ-AD004, for the first time in people with advanced solid tumors that have spread or cannot be removed. The goal is to find a safe dose and see if it can shrink tumors. About 121 adults aged 18 to 75 will take part.

This study is testing a procedure called radiation segmentectomy for adults with liver cancer. Doctors deliver tiny radioactive resin beads directly to the tumor's blood supply to kill cancer cells while sparing healthy tissue. The goal is to find the best radiation dose for comp…

This study tests a combination of two experimental drugs, SHR-1501 and adbelizumab, in people with advanced or metastatic solid tumors that have not responded to standard treatments. The goal is to find a safe dose and see if the combination can shrink tumors. About 203 adults ag…

This study tests a new gel called INT001 that is injected directly into liver tumors to kill them. About 31 adults with liver cancer who cannot have surgery will receive one injection and be followed for 90 days. The goal is to see if the gel safely destroys the tumor and what si…

This Phase 1 trial tests TQB6411, an antibody-drug conjugate designed to bind to EGFR and c-Met proteins on tumor cells, blocking their growth signals and releasing a toxin to kill the cells. The study will enroll 216 adults with advanced malignant tumors to find the safest dose …

This study tests whether giving radiotherapy early to high-risk bone metastases that are not yet causing symptoms can prevent future bone complications like fractures. About 120 adults with solid tumors and at least three bone metastases will be randomly assigned to either standa…

This early-stage trial is testing a new drug called IL12-L19L19 (Dodekin) in 80 adults with advanced or metastatic solid tumors that have stopped responding to standard immunotherapy. The drug combines an antibody with an immune-boosting protein to target and attack cancer cells.…

This early-phase trial tests an inhaled mRNA vaccine called BMD006 in 83 people with advanced lung cancer or solid tumors that have spread to the lungs. The vaccine is designed to train the immune system to attack tumor-associated antigens. The study will check safety, tolerabili…

This early-stage study tests a new drug called ASD141 in 21 adults with advanced solid tumors that have not responded to standard treatments. The main goals are to check the drug's safety, find the right dose, and see if it can shrink tumors. Participants will receive the drug an…

This study tests a new drug called ADG126 combined with pembrolizumab (a standard immunotherapy) in people with advanced or metastatic solid tumors that have not responded to other treatments. The goal is to find the safest dose and see if the combination can shrink tumors. About…

This study is tracking 50 people with cancer that has spread to the bones (bone metastases) to see if freezing those tumors with a special probe (cryoablation) can control them. The goal is to prevent local tumor growth, ease pain, and improve quality of life. Participants have l…

This study tests a new injection called SHR-2017 in 210 adults with solid tumors that have spread to their bones. The goal is to see if it can prevent bone complications like fractures and pain, compared to an existing drug (denosumab). Participants will receive either high or lo…

This early-stage study tests a new drug called PMC-309, alone or with another drug (pembrolizumab), in people with advanced solid tumors that have not responded to other treatments. The main goal is to check safety and find the best dose. About 67 adults will take part.

This phase III trial tests whether adding stereotactic ablative radiotherapy (SABR) to standard treatment (chemotherapy, hormone therapy, or palliative radiation) improves survival in adults with 1 to 10 metastatic tumors and an active primary cancer. About 180 participants will …

This study tests a new way to treat small lung tumors by freezing them. Doctors use a special scope to guide a freezing probe directly to the tumor. The trial includes 40 adults with early-stage or limited metastatic lung cancer. The goal is to see if the procedure is safe and ca…

This early-stage trial is testing an experimental drug called RBS2418, taken as a pill, to see if it can help the immune system fight advanced cancers that have spread or come back. The study involves 164 adults with various solid tumors who have already tried standard treatments…

This study tests a combination of three drugs (surufatinib, sintilimab, and capecitabine) in people with advanced small bowel or appendix cancer that has spread and stopped responding to standard treatments. The goal is to see if this mix can shrink tumors or slow cancer growth. …

This early-stage trial is testing an investigational drug called JZP898, both by itself and together with the immunotherapy pembrolizumab, in adults with advanced or metastatic solid tumors that have not responded to standard treatments. The main goals are to check safety, find t…

This early-phase study tests a new drug, LNCB74, in people with advanced solid tumors (ovarian, breast, endometrial, bile duct, or lung cancer) that have not responded to standard treatments. The drug is designed to deliver a cancer-killing agent directly to tumor cells. The main…

This study looks at whether giving two chemotherapy drugs (capecitabine and temozolomide) after surgery can prevent or delay the return of high-risk pancreatic neuroendocrine tumors. About 141 people who have had their tumor removed will be randomly assigned to receive the drugs …

This study compares carbon fiber and titanium screws in people with cancer that has spread to the spine. The goal is to see if carbon screws cause fewer imaging problems, making it easier to plan radiation therapy and spot cancer return. About 226 adults will take part, and the s…

This phase II trial tests a treatment called HIPEC, where heated chemotherapy drugs are placed directly into the abdomen during surgery. It is for people with pancreatic cancer that has spread to the lining of the abdomen. The study will enroll 40 participants to see if this appr…

This study tests whether a precise, high-dose radiation technique called SABR works better than standard palliative radiation for people whose cancer has spread to a few new spots while on treatment. About 194 adults with solid tumors (excluding lymphoma or myeloma) and up to 5 g…

This early-stage trial tests an experimental drug called ADU-1805, alone or combined with the immunotherapy Keytruda, in adults with advanced solid tumors that have stopped responding to standard treatments. The main goals are to check safety and find the right dose. About 130 pa…

This early-phase trial tests a new therapy called NW-101C, which uses a patient's own immune cells (T cells) that have been genetically modified to recognize and attack cancer cells carrying a protein called PRAME. The study will enroll 24 adults with advanced solid tumors that h…

This early-phase trial is testing a new approach called Peptide Alarm Therapy (PAT) for people with advanced solid tumors that have not responded to at least one prior treatment, including immunotherapy. PAT is injected directly into a tumor along with a standard PD-1 inhibitor d…

This early-phase study tests a new drug called SIM0609 in adults with advanced solid tumors that have not responded to standard treatments. The main goals are to check the drug's safety, find the right dose, and see if it can shrink tumors. About 232 participants will take part a…

This study tests two or three drugs (defactinib, avutometinib, and possibly encorafenib) in people with advanced melanoma that has spread to the brain. The goal is to see if these combinations can shrink brain tumors and how safe they are. About 33 adults whose melanoma worsened …

This study tests whether giving two drugs directly into the spinal fluid can shrink or control breast cancer that has spread to the lining of the brain. It is for people with HER2-positive breast cancer. The drugs are given through a small device placed under the scalp. The goal …

This study tests a new treatment called BioTTT001, a modified virus designed to attack cancer cells, in 42 adults with recurrent non-small cell lung cancer that has spread to the lining of the brain. The treatment is given through a small device placed in the head. The main goals…

This study tests a new drug called RC278 in people with advanced solid tumors that cannot be removed by surgery or have spread. The main goals are to find a safe dose and see if the drug can shrink tumors. About 312 adults aged 18 to 75 with good overall health are being recruite…

This early-phase study tests a technique called in vivo lung perfusion (IVLP) that delivers chemotherapy directly into the lung during surgery to remove sarcoma tumors that have spread to the lungs. The goal is to kill any tiny cancer cells left behind that could cause the cancer…

This study is for people with HER2-negative breast cancer that has spread to the lining of the brain (leptomeningeal metastasis). It compares standard chemotherapy given through the veins or by mouth to the same treatment plus extra chemotherapy delivered directly into the spinal…

This early-phase trial is testing a new approach for people with liver metastases (cancer that has spread to the liver from elsewhere). Doctors are using a procedure called TACE to deliver the drug bevacizumab directly into the liver's blood vessels, aiming to concentrate the tre…

This early-phase trial is testing whether a new imaging agent called SLR-108 can improve PET scans for people with metastatic solid tumors. SLR-108 is an antibody that carries a small amount of radioactivity and is designed to attach to tumor cells, making them more visible on a …

This study tests a new type of PET scan that uses a special tracer (Ga68-PSMA) to see if it can tell the difference between a growing tumor and radiation damage in people with brain metastases from lung cancer, melanoma, or breast cancer. About 100 adults who have had radiation t…

This phase 1 trial is testing whether a new imaging tracer called 18F-TRX can safely and effectively detect solid tumors using PET scans. The tracer targets unstable iron levels, which are often elevated in cancerous tissue. Adults with advanced solid tumors, including certain pr…

This trial evaluates a radioactive tracer called 68Ga-DOTA/NOTA-FAPI-04, given as a single injection before a PET/CT scan, to see if it can better identify primary tumors and metastases in people with various cancers. Researchers will measure how strongly the tracer accumulates i…

This pilot study tests a special PET/MRI scan that uses a radioactive tracer to find HER2+ breast cancer that has spread to the brain. The scan aims to show whether the cancer cells take up the tracer, which might predict if they will respond to the standard drug trastuzumab deru…

This study tests a new type of PET/MRI scan to see if it can better tell the difference between a growing brain tumor and changes caused by radiation or immunotherapy. About 30 adults with brain metastases who have had radiation in the last 2 years will get a single 3-hour scan s…

This study is testing whether a new contrast agent called gadopiclenol (VUEWAY) can improve MRI scans to detect leptomeningeal disease (LMD), a condition where cancer spreads to the lining of the brain and spinal cord. Researchers will compare it to the standard contrast agent ga…

This study looks at whether adding an early PET scan right after the injection can better tell the difference between a brain tumor coming back and damage from radiation therapy. About 50 adults with brain metastases who already need a PET scan will get an extra 15-minute scan ri…

This early-phase study tests a new radioactive tracer called FAP-2286 to see how well it can detect cancer that has spread in adults with solid tumors. About 191 participants will receive the tracer and then have a PET scan. The goal is to measure safety and how clearly the trace…

This study tests a new type of PET/CT scan that uses a radioactive tracer called 68Ga-ABS011 to detect HER2, a protein found on some cancer cells. The goal is to see if this scan can more accurately determine HER2 status in people with metastatic breast cancer or other solid tumo…

This study is testing a new, quick MRI technique called Magnetic Resonance Fingerprinting (MRF) to better tell the difference between a brain tumor coming back and damage from radiation therapy (radiation necrosis). About 90 people will take part, including healthy volunteers, pa…

This study aims to develop a blood test that detects RNA from tiny particles (exosomes) to predict if prostate cancer has spread to the bones. Researchers will analyze blood samples from 1,000 men with newly diagnosed prostate cancer and compare results with PSMA PET scans. The g…

This early-stage trial is testing a new radioactive tracer called 68Ga-FXX489 (NNS309) for PET/CT scans. The goal is to see if it can safely and accurately detect tumors and their spread in 30 adults with suspected cancer. Researchers will measure how the tracer moves through the…

This study tests a radioactive tracer called FET that lights up brain tumor cells on a PET scan. Researchers want to see if FET can better detect whether a brain tumor has come back after treatment, and help tell high-grade from low-grade tumors. About 199 people with known or su…

This study compares whole body diffusion-weighted MRI (DWI) to standard FDG PET/MRI scans in 30 adults with metastatic cancer. The goal is to see if DWI can spot cancer lesions as well as the PET scan, which uses a radioactive tracer. Participants will undergo both scans, and res…

This study aims to see if a special MRI scan called CEST can accurately tell apart radiation damage from tumor growth in people with lung cancer that has spread to the brain. About 60 adults who have had radiation therapy for brain metastases and show new changes on follow-up MRI…

This phase I/II trial tests a radioactive tracer called 64Cu-GRIP B, which targets granzyme B—a substance released by immune cells. By using PET scans, researchers hope to see immune activity in tumors and predict whether immunotherapy will work. The study involves about 91 adult…

This study tests a special MRI technique to help doctors tell whether an enlarged spot in the brain after radiation is the tumor growing back or harmless scar tissue from the radiation. About 100 adults with brain metastases who had radiation will get this MRI before any surgery.…

This study compares a special PET scan (68Ga-PSMA) with standard CT scans to see which better detects where kidney cancer has spread in 300 adults with advanced disease. Participants will receive both scans, and doctors will check if the PET scan changes treatment plans. The goal…

This study tests whether using two contrast agents (gadolinium and ferumoxytol) in one MRI session can improve the detection and diagnosis of brain and central nervous system abnormalities. About 150 participants with neurological symptoms or known brain lesions will undergo imag…

This early-phase study is testing a new radioactive tracer for PET scans that may better detect non-small cell lung cancer that has spread to the brain. About 20 adults with this type of lung cancer and brain metastases will receive the tracer and undergo imaging. The goal is to …

This study tests a special dye, panitumumab-IRDye800, that attaches to lung cancer cells and makes them glow under a special camera during surgery. The goal is to help surgeons see and remove all cancer tissue more accurately. About 30 adults with lung cancer or lung metastases w…

This study tests a device called the CONVIVO system, which acts like a high-powered microscope during brain tumor surgery. It helps surgeons tell the difference between normal and abnormal tissue right away. About 30 adults with various brain tumors will take part. The goal is to…

This study is testing an artificial intelligence model that combines CT scans, tissue images, and patient data to predict whether colorectal cancer will spread to the liver after surgery. Researchers will enroll 160 patients across multiple hospitals and follow them for two years…

This study tests a new MRI sequence that aims to make brain tumors (metastases) more visible after a standard contrast injection. Researchers will compare the new method to the usual MRI in 100 adults with known or suspected brain tumors. The goal is to see if the new scan finds …

This early study tests a special PET/CT scan that uses a modified tryptophan molecule to make tumors light up more clearly than normal tissue. About 24 adults with brain, breast, neuroendocrine, or rectal cancers will get one scan to see if this method helps doctors tell tumors a…

This study tests two advanced MRI techniques to better tell apart brain tumors that have come back from tissue damage caused by radiation therapy. About 42 adults with brain metastases will be scanned before surgery or radiation. The goal is to help doctors make more accurate tre…

This study aims to improve how doctors find and treat breast cancer that has spread to the brain. Twenty adults with ER-positive breast cancer and brain tumors will get an extra PET scan (FES PET/CT) before their standard radiation planning. Researchers will compare this scan wit…

This study tests a mobile app called PACT that helps people with advanced cancer talk about and plan the care they would want if they couldn't speak for themselves. The app involves patients and their loved ones in these discussions. Researchers want to see if the app is easy to …

This study tests whether a single, quick radiation session can treat painful bone metastases without the usual planning visit. About 40 adults with cancer and one or two painful bone spots will get one dose of radiation in a single trip to the hospital. The goal is to see if this…

This early-phase trial is testing whether a minimally invasive procedure using special light-activated nails can help stabilize the pelvis in people whose cancer has spread to the bone around the hip socket. Fifty adults with confirmed cancer and visible pelvic metastases will be…

This phase 3 trial tests whether a precise, high-dose radiation technique (SBRT) provides better pain relief than standard radiation for cancer patients with painful bone metastases not in the spine. About 230 adults with solid tumors and moderate to severe pain will be randomly …

This study tests whether a CPAP device can reduce tumor movement in lung cancer patients during stereotactic body radiation therapy (SBRT). About 30 participants will use CPAP or deep inspiration breath hold to see which better stabilizes tumors. The goal is to improve treatment …

This study tests a practical geriatric assessment (PGA) for adults aged 70+ with advanced cancer. The PGA is a questionnaire completed before a doctor visit, and results are shared with the care team to help guide chemotherapy dosing. Researchers will also track step counts with …

This study tests whether giving spine radiation in one session or two sessions better prevents bone fractures in people with cancer that has spread to the spine. About 130 adults with spine tumors will receive either one or two focused radiation treatments. The goal is to find wh…

This study is for people whose cancer has spread to the brain. It compares two types of whole brain radiation: one that avoids only the memory center (hippocampus) and one that also avoids other brain areas tied to thinking. The goal is to see which better preserves memory and co…

This study tests whether adding telephone health coaching to a symptom management handbook helps reduce symptom burden and improve quality of life for people with metastatic breast, GI, or melanoma cancer and their caregivers. About 200 participants will be split into two groups:…

This study tests the ApricityCare program, which helps people with metastatic cancer and their doctors spot treatment side effects early. The goal is to manage these side effects quickly so patients can stay on their cancer therapy longer. About 425 adults starting systemic cance…

This Phase 2 trial tests a new type of radiation therapy designed to avoid key brain areas involved in memory and thinking. Sixty adults with 1 to 3 small brain metastases will receive cognitive-sparing stereotactic radiosurgery. The main goal is to see if this approach better pr…

This study tests a new program called EASE, which uses a simple writing exercise to help adults with advanced cancer manage their fear of the future and related trauma symptoms. The study will include 250 people with advanced solid tumors, glioblastoma, or certain ovarian or lung…

This study tests whether group sessions that teach stress management skills can lower distress in people with cancer. About 400 adults with cancer who have moderate distress will take part. The program helps patients recognize and reduce stress in their daily lives.

This study tests whether a very low dose of radiation (2 Gy) can relieve bone pain in people with multiple myeloma that has spread to the bones. The goal is to see if this gentler approach works as well as standard radiation but with fewer side effects and less disruption to chem…

This study is looking at whether combining two treatments — a minimally invasive procedure called percutaneous ablation and standard radiation therapy — can better relieve pain from bone cancer that has spread. Researchers will follow 120 people whose pain is not controlled by me…

This phase 2 trial tests whether a higher dose of radiation (40-50 Gy over 10 sessions) can better relieve pain from cancer that has spread to bones or other areas. Researchers hope to double the complete pain response rate at one month compared to standard doses. The study invol…

This study looks at whether asking people with advanced cancer about their financial struggles each month can help reduce their worry and improve their quality of life. About 1,000 adults receiving treatment for advanced or metastatic cancer will be randomly assigned to either mo…

This study tests whether offering a palliative care consultation early—when patients with advanced cancer and bone metastases start radiotherapy—improves their satisfaction with care and quality of life. About 246 participants will be randomly assigned to receive either a tailore…

This study looks at whether a procedure called arterial embolization can reduce pain and improve quality of life in people with bone metastases (cancer that has spread to the bones). The procedure blocks blood flow to the tumor, which may shrink it and ease symptoms. Researchers …

This study tests whether having spine surgery and radiation on the same day helps people with painful spinal tumors recover physical function faster than the usual approach of surgery followed by radiation weeks later. About 100 adults with unstable spinal metastases will be rand…

This study tests a special type of radiation called lattice therapy for people with large, hard-to-treat tumors. The goal is to see if it can shrink tumors better than standard radiation and help people feel better. About 37 adults with advanced solid tumors will receive this tre…

This study tests whether a single, precise dose of radiation (SBRT) can relieve pain and improve quality of life in people with cancer that has spread, compared to the usual multiple sessions of standard radiation. About 1,500 participants with metastatic tumors causing symptoms …

This study tests whether combining three treatments—kyphoplasty (spine stabilization), radiofrequency ablation (heat to destroy tumor tissue), and standard radiation—can better reduce pain from spine tumors. About 70 adults with cancer that has spread to the middle or lower back …

This study tests a new type of whole brain radiation that spares healthy tissue, aiming to improve quality of life and reduce symptoms for people with brain metastases. About 41 adults with solid tumors and brain metastases will receive this radiation plus a standard drug. Resear…

This study tests a procedure that uses radiofrequency heat to destroy spine tumors, followed by bone cement to stabilize the spine. Sixteen people with cancer that has spread to the spine will receive the treatment. The goal is to see if the tumors become less active on PET scans…

This study compares a new radiation technique called lattice radiation therapy (LRT) to standard stereotactic body radiation therapy (SBRT) for people with solid tumors that have spread to soft tissues. The goal is to see if LRT shrinks tumors better and helps the immune system f…

This early trial tests whether minoxidil (Rogaine) — applied to the scalp or taken as a pill — can help with hair loss caused by hormone therapy in breast cancer patients. About 50 women with stage I-IV breast cancer who report hair thinning since starting endocrine therapy will …

This study tests a parenting support program for 120 parents with advanced cancer and their spouses. The program aims to reduce parenting worries, improve family communication about cancer, and boost emotional wellbeing. Participants must have a child aged 4-16 living at home and…

This study tests whether a cream containing tretinoin (a form of vitamin A) can prevent or reduce the acne-like rash that often occurs in patients taking certain cancer drugs. About 25 adults with advanced solid tumors will apply the cream to one side of their face and a placebo …

This study tests whether slowly reducing the dose of the steroid dexamethasone after brain tumor surgery can lower side effects like high blood sugar and poor wound healing, while still preventing brain swelling. About 200 adults with certain brain tumors will be randomly assigne…

This study tests a new way of giving palliative radiation (HART) to people with metastatic cancer. The goal is to see if it causes fewer stomach and bowel side effects than standard radiation. About 103 adults with cancer that has spread will receive HART to bones or soft tissues…

This study compares a single, higher-dose palliative radiotherapy session to the usual 5-10 sessions for people with metastatic cancer. The goal is to see if one strong dose can keep symptoms away longer, up to 12 months. About 100 participants will be enrolled to measure how lon…

This study compares intensive multi-disciplinary care (a team of specialists working together) to standard care for 40 adults with newly diagnosed brain metastases from solid tumors. The goal is to see if the team approach reduces symptom burden and helps patients better understa…

This study tests a new program designed to help people with brain metastases manage thinking and memory problems. About 140 patients will receive different levels of support based on their needs, from educational materials to one-on-one coaching. The goal is to see if the program…

This study tests a newer, more precise radiation method called SBRT against standard radiation to see which better relieves pain from cancer that has spread to the bones. About 220 adults with solid tumors or multiple myeloma and pain at the treatment site will take part. The goa…

This study tests two support programs for parents with advanced cancer who have children aged 10 to 25. One program provides information and tips; the other adds exercises and emotional support. Researchers want to see which helps parents communicate better and feel more confiden…

This study tests a high-fiber product called NBT-NM108 in 42 people with advanced colon cancer who are receiving a chemotherapy drug called irinotecan. The goal is to see if the supplement can reduce or prevent the severe diarrhea that often comes with this treatment. By helping …

This study tests whether adding a special heat treatment (water-filtered infrared, or wIRA) to standard palliative radiation can help shrink tumors and ease symptoms in people with advanced head, neck, or skin cancer that cannot be cured. About 60 adults will receive the combined…

This phase 3 trial is testing whether adding chaplain-provided spiritual care or psychotherapy/meditation to standard palliative care can improve survival and quality of life in people with advanced, non-curable cancer. About 854 participants with a life expectancy of one year or…

This study tests whether using an MRI machine to guide radiotherapy can treat metastatic spinal cord compression in a single one-hour appointment, instead of the usual two visits (a planning CT scan then radiotherapy). About 72 adults with confirmed spinal cord compression will b…

This study uses special MRI scans to see how radiation treatment affects the brain's white matter and thinking skills in people with cancer that has spread to the brain. Researchers will follow 15 patients to find early signs of memory or concentration problems. The goal is to be…

This early-phase trial will test a new PET imaging agent called 64Cu-DOTA-pembrolizumab in 6 people with stage IV non-small cell lung cancer who are already on the immunotherapy drug pembrolizumab. The goal is to see if the imaging agent can safely tell the difference between tum…

This study looks at men with advanced prostate cancer that has spread to the bones. Researchers want to see if certain DNA repair problems in the cancer cells make the drug radium-223 work better or worse. The goal is to help doctors choose the best treatment for each patient in …

This study is observing about 800 adults with advanced breast cancer (HER2-positive, low, or ultralow) who are receiving the drug trastuzumab deruxtecan as part of their normal care in Germany. Researchers are tracking how long patients stay on the drug before switching treatment…

This large screening trial enrolls up to 2,900 people with advanced solid tumors that have spread or not responded to standard treatment. Researchers use genetic tests on tumor samples to find specific mutations, then assign patients to treatment trials testing drug combinations …

This study provides ongoing check-ups for people who received a donor stem cell transplant at the NIH at least three years ago. Researchers will monitor for late side effects, disease return, and overall health. Participants will have yearly visits that may include blood tests, b…

This study explores whether a tool called SmartMatch can quickly analyze tumor tissue from standard surgeries or biopsies to suggest personalized treatment options for people with rare, advanced gynecologic cancers. The goal is to see how often SmartMatch can produce a useful tre…

This study explores whether magnetic resonance spectroscopy (MRS) can be used to safely evaluate spinal cord lesions. Researchers will test the technique in healthy volunteers and patients with leptomeningeal disease who are receiving radiation. The main goal is to see if MRS is …

This study is testing whether a smartwatch can track changes in walking and daily activities in people with bone cancer (osteosarcoma or metastatic bone disease). The goal is to see if the watch can help doctors spot problems early and personalize care. About 60 participants will…

This pilot study will test whether a special PET/MRI scan can detect real-time artery inflammation in the heart after chest radiation therapy. Ten adults with stage II-III or limited stage IV cancer who are at high risk for heart problems will be scanned before and 6 months after…

This study collects tissue and blood samples from 1,500 people with prostate or bladder cancer that has come back or spread. Researchers will analyze the samples to find genetic changes and other markers that may explain why some cancers stop responding to treatment. The goal is …

This study tests whether a brain mapping technique called navigated transcranial magnetic stimulation (nTMS) can help doctors plan radiation therapy better for people with brain metastases near the motor cortex. About 30 patients who had surgery for a brain tumor will get both a …

This study looks at why some older adults with serious conditions like cancer or fractures become vulnerable or frail. Researchers will follow about 1500 patients to find out how common different causes of vulnerability are and how they affect outcomes like survival and quality o…

This pilot study is exploring whether a one-time sample of spinal fluid (taken via a lumbar puncture) can detect cancer DNA in patients with solid tumors that have spread to the brain or spinal cord. Researchers will enroll 60 participants across three groups: those with leptomen…

This large observational study is testing whether a blood-based 'liquid biopsy' can detect tumor mutations and track disease progression in people with metastatic or advanced solid tumors who are receiving palliative care. Researchers will compare results from liquid biopsies wit…

This study aims to safely collect health information like heart rate and activity levels from cancer patients using devices like smartphones and wearables. Researchers will use this data to learn more about how it relates to cancer diagnosis, treatment response, and risk factors.…

This study is testing a special type of MRI scan to see if it can better measure how colorectal cancer liver tumors respond to chemotherapy. About 70 people with liver metastases that have not been treated yet will get the scan before and after chemo. The goal is to improve how d…

This study looks at whether detailed genetic testing of tumor tissue or blood can help doctors make better treatment decisions for people with advanced solid tumors or primary brain cancers. About 550 participants will have their tumors genetically profiled, and a smaller group w…

This study collects health information from 500 adults with painful bone metastases that have spread from other cancers. Researchers aim to better understand the disease and track survival over time. No new treatments are given; participants simply share their medical data.

This study tests whether offering hearing tests close to home or remotely increases how many head and neck cancer patients get their hearing checked during treatment. Many patients on cisplatin chemotherapy or radiation near the ear can lose hearing, but not all complete recommen…

This study is testing whether wearing a fitness tracker (like a Fitbit) can give doctors a better picture of how active cancer patients are, and whether that activity level relates to how well they are doing overall. About 590 people with various cancers will wear activity monito…

This study tests whether having a specialist review genetic test results and guide treatment decisions can increase the use of targeted therapies for people with advanced solid tumors, including breast, lung, colorectal, and bladder cancers. Participants will have their tumor or …

This study enrolls 1,000 adults with advanced solid tumors that have progressed after standard treatment. Researchers will use genetic tests to match patients to specific drugs, like Alectinib or Atezolizumab, based on their tumor's gene changes. The goal is to see if this person…

This study from Mayo Clinic is looking at how T cells (a type of immune cell) change during anti-PD-1 immunotherapy in people with advanced melanoma, lung cancer, or other solid tumors. Researchers will collect blood and tissue samples from 500 participants to measure specific ma…

This observational study tracks over 10,000 people with advanced or metastatic cancer to understand why outcomes vary by race and background. Researchers collect social, genetic, and treatment data from patients at four cancer centers. The goal is to identify factors—like social …

This study looks at 100 people with advanced solid tumors whose cancer stopped responding to immunotherapy. Researchers will take a fresh tumor sample and blood tests to compare genetic and immune differences between those who never responded and those who initially improved but …

This study looks at DNA and protein changes in tumor samples from 50 adults with aggressive or metastatic cancer. Researchers aim to find new markers for diagnosis and potential drugs. Participants provide blood, cheek swabs, and tissue from standard biopsies or surgeries.

This study uses a special microscope called intravital microscopy to look at blood vessels inside solid tumors while patients are in surgery. Researchers want to see how these vessels work and how well they let blood and dye flow through. The goal is to learn whether tumor vessel…

This study looks at genetic changes in patients with colorectal cancer that has spread only to the liver and cannot be removed by surgery. Researchers will perform liver transplants and then analyze tumor genetics and blood samples to better understand why the cancer spreads and …

This study looks at whether precise radiation (SRS or SBRT) can help preserve thinking and memory in people with multiple brain tumors that have spread from other cancers. About 90 adults with 1 to 10 brain metastases will get radiation and then take thinking tests over 4 months.…

This study looks back at 600 patients who had surgery for a broken or about-to-break upper thigh bone caused by cancer that spread from elsewhere. Researchers will compare two surgical methods—a metal rod inside the bone or a replacement joint—to see which one leads to fewer comp…

This study is testing whether a special PET scan (using 18F-Fluciclovine) can help doctors see if brain tumors are responding to radiation treatment. About 46 adults with brain metastases will get the scan before and after stereotactic radiosurgery. The goal is to find a better w…

This study is building a registry of 500 children, teens, and young adults (ages 1-39) diagnosed with cancer. Participants will complete physical and mental function tests, surveys, and provide blood samples over time. The goal is to learn how cancer and its treatments affect agi…

This study is testing a simple scoring system to predict whether people with metastatic cancer will survive at least 30 days after starting palliative radiation therapy. The score uses lab results, emergency room visits, and cancer type. About 214 adults will join to see if the t…

This registry is collecting information from 2,000 people with metastatic cancer who are receiving radiation therapy as part of their standard care. Researchers will gather clinical data and patient-reported outcomes to better understand how radiation affects cancer outcomes. The…

This study looks at whether a simple blood test can find tiny bits of cancer DNA left after surgery for stage III colorectal cancer. The goal is to see if this test can help doctors decide who really needs extra chemotherapy and who can skip it. About 590 people will give blood s…

This study looks at people with advanced lung cancer who have lived at least three years after diagnosis and are no longer on chemotherapy. Researchers want to understand their health, quality of life, and social or financial challenges. Participants will fill out questionnaires …

This study is testing a new radioactive tracer called [C-11]-CS1P1 that lights up inflammation in brain tumors during a PET scan. Researchers will scan 104 adults with primary or secondary brain cancers before and after treatment to see how inflammation patterns change. The goal …

This study tests whether a special PET scan (EstroTEP) and blood tests can help doctors pick the best second-line treatment for people with ER-positive, HER2-negative metastatic breast cancer. About 300 participants will be assigned to either endocrine therapy or chemotherapy bas…

This pilot study is looking for better ways to see if endocrine therapy is working in people with a type of breast cancer called metastatic invasive lobular carcinoma. Researchers will use a special PET scan and blood tests to measure changes in estrogen signaling after 4 weeks o…

This study creates a registry for people with leptomeningeal disease, a rare condition where cancer spreads to the lining of the brain and spinal cord. Researchers will collect information on how the disease progresses, what treatments are used, and any side effects. The goal is …

This study is testing whether using simple blood tests to decide when to do scans is as effective as the usual approach of regular scans for people with advanced breast cancer. About 739 participants will be randomly assigned to either blood test monitoring or standard care. The …

This study looks at the fluid around the brain (cerebrospinal fluid) in people with breast cancer that has spread to the brain or its lining. Researchers collect this fluid to study the cancer's genetic material without needing surgery. The goal is to better understand why breast…

This study will follow 2500 cancer patients with bone metastases to better understand why some respond to radiation therapy and others do not. Researchers will collect data to build tools that predict pain relief and survival, and to create a platform for testing new treatments. …

This study tests whether doing radiation planning and treatment on the same day can better target fast-growing brain metastases. About 60 adults with brain tumors that grow at least 1mm per week will be randomly assigned to receive radiation with a 1mm or 0mm safety margin. The g…

This study looks at people with small intestinal neuroendocrine tumors that have spread and cannot be cured. It compares those who had surgery to remove the main tumor plus other treatments against those who had only other treatments. The goal is to see if surgery helps patients …

This study looks at tissue samples from 30 adults with stomach or esophageal cancer that spread to the brain. Researchers compare the genetic markers of the original tumor and the brain tumor to see if they differ. The goal is to better understand how these cancers change when th…

This study looks at how Y90 radioembolization, a radiation treatment for liver tumors that have spread from colorectal cancer, actually works inside the body. Researchers will collect small tissue samples (biopsies) from the liver after treatment to see how much tumor damage occu…

This observational study uses a special MRI technique with hyperpolarized carbon-13 pyruvate to see how brain tumors use energy. Researchers will measure metabolic byproducts in 25 adults with brain tumors before any treatment. The goal is to learn more about tumor metabolism, no…

This study collects tissue and blood samples from up to 5,000 cancer patients of all ages. The samples are used to create lab models, such as cell lines and animal models, to help scientists better understand cancer and test new treatments. Participants do not receive direct trea…

This phase 2 trial is testing whether CT and MRI scans can act as biomarkers to predict how patients with brain metastases respond to radiation therapy. About 90 adults with brain metastases who are scheduled for radiation will get scans before and after treatment. The goal is to…

This study aims to develop and test a new MRI technique to distinguish between actual tumor growth and changes caused by radiation treatment in people with brain metastases. Researchers will include both healthy volunteers and patients who have had stereotactic radiosurgery. The …

This study is testing whether a special smart shirt, called Hexoskin, can help monitor side effects in 100 patients receiving palliative radiotherapy for cancer that has spread. The shirt tracks heart rate, breathing, and activity levels. The goal is to see if it's practical to u…

This study observes 100 adults with painful spinal metastases to see how doctors choose between two radiation types: standard palliative radiation (CRT) and a more precise, high-dose form (SBRT). Researchers will track pain relief, tumor control, and the reasons behind treatment …

This study looks at how much of the drug T-DXd enters brain tumors in people with HER2-positive brain cancers or glioblastoma. Thirty participants will receive T-DXd before surgery to remove a brain tumor, and researchers will measure drug levels in the tumor. The goal is to see …

This study is testing a new approach called Functional Precision Oncology for people with triple-negative or HR-low/HER2- breast cancer at high risk of early recurrence. Researchers will create personalized tumor models (in mice and lab dishes) from each patient's cancer to find …

This study looks back at medical records of 350 people with cervical cancer that has come back or spread to a few spots. The goal is to see how well treatments like radiation or surgery work, alone or with chemotherapy. Researchers want to find out which patients benefit most fro…

This study looks at how people with advanced cancer feel about stopping or reducing medications that may no longer help. Researchers will interview about 25 patients and survey 300 more to understand their attitudes and beliefs. The goal is to learn what factors influence their v…

This study is a registry that collects information from 300 adults with metastatic cancer who receive or have received a precise, high-dose form of radiation called ablative radiotherapy. The goal is to track short-term side effects and better understand the safety of this treatm…

This early-phase study tests a special PET imaging agent that highlights immune cells (CD8+ T-cells) in brain tumors. About 20 adults with brain tumors scheduled for surgery will receive an injection of the imaging agent before their PET scan. The goal is to see if this non-invas…

This study is testing a special MRI technique called CEST to create detailed maps of acidity (pH) inside brain tumors like gliomas and metastases. Researchers will scan 800 patients who are already getting a PET/MRI for their brain tumor. The goal is to see if pH levels can help …

This study looks at how much radiation reaches tumors and healthy organs during a treatment called 177Lu-PSMA-617 for advanced prostate cancer that has spread. Researchers want to see if the radiation dose can predict how well the treatment works and what side effects might occur…

This study is testing a special MRI technique that uses a substance called hyperpolarized 13C-pyruvate to look at how brain metastases (tumors that spread to the brain) use energy. The goal is to see if this scan can help doctors understand which tumors are more likely to resist …

This early-phase trial is testing whether a special PET scan can track immune cells called CD8+ T cells in cancer patients before and after radiation therapy. The study includes 10 people with lymphoma or solid tumors that have spread. Researchers hope this imaging method could o…

This study is collecting blood and tumor samples from 730 newly diagnosed lung cancer patients at Nantes University Hospital. Researchers will follow patients from diagnosis until death to understand how treatments work in real life, especially for patients often left out of clin…

This study is building a large collection of blood, tissue, and fluid samples from 7,000 people with lung cancer, other chest diseases, or lung transplants. The goal is to help researchers learn more about what causes these diseases, how to find them early, and how to treat them …

This study is for people with colorectal cancer that has spread to the liver and cannot be removed by surgery. Researchers want to learn how the body responds to a treatment called SIRT, which delivers tiny radioactive beads to the liver. They will collect blood and tissue sample…

This study uses brain mapping techniques like fMRI and MEG before, during, and after surgery to see how brain functions like movement and speech reorganize in people with brain tumors. Researchers hope to improve surgical planning and preserve important brain functions. The study…

This study looks at memory, thinking, and mood problems that can happen with certain targeted lung cancer drugs (ALK/ROS1 inhibitors). About 20 patients who have these side effects will undergo detailed brain and psychiatric tests. The goal is to better understand these issues an…

This study compares two ways of delivering precise radiation to brain tumors that have spread from other cancers. One group gets the standard extra 2-millimeter safety margin around the tumor, while the other group gets no extra margin. The goal is to see if skipping the margin l…

This study is looking at whether analyzing the DNA of a patient's tumor can help doctors pick more effective treatments. Researchers will profile tumors from 100 adults with advanced, incurable cancer to see if they can find genetic changes that match existing drugs or clinical t…

This study is growing miniature versions of breast cancer tumors, called organoids, from samples taken during surgery. Researchers want to see if these lab-grown organoids can predict how well a patient's cancer will respond to treatments like chemotherapy or radiation. If the or…

Researchers are gathering medical records, scans, and lab results from 250 patients with bone metastases that spread from other cancers. They will use this data to create a dataset called RAW, which will help develop computer models to predict fracture risk and life expectancy. T…

This study tests whether a special PET scan using an investigational agent called 18F-Fluciclovine can find leftover tumor tissue after brain metastasis surgery better than standard MRI. About 20 adults who have had brain tumor surgery and are scheduled for radiation will get an …

This study enrolls 30 adults with breast cancer that has spread to the lining of the brain or spinal cord (leptomeningeal disease). Researchers will collect tissue and fluid samples to learn more about this aggressive condition. The goal is to provide faster test results and trea…