New drug YH32364 targets Hard-to-Treat cancers in first human trial
NCT ID NCT06975410
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tests an experimental drug called YH32364 in adults with advanced solid tumors that have high levels of EGFR and have not responded to previous treatments. The trial has two parts: first, finding a safe dose in about 30 people, then testing that dose in 50 people with a specific type of head and neck cancer. The goal is to see if the drug is safe and can shrink tumors.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- YH32364 (an experimental drug)
- What this could lead to
- If successful, this could lead to a new treatment option for people with advanced cancers that have high levels of EGFR and have not responded to prior therapies.
- What could go wrong
- This is an early first-in-human study with a small number of participants. The drug may not shrink tumors or could cause unexpected side effects. It is too soon to know if it will work.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Email: •••••@•••••
Locations
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Korea University Anam Hospital
RECRUITINGSeoul, 02841, South Korea
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Samsung Medical Center
RECRUITINGSeoul, 06351, South Korea
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Seoul National University Hospital
RECRUITINGSeoul, 03080, South Korea
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Severance Hospital
RECRUITINGSeoul, 03722, South Korea
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