Can a cream stop cancer Treatment's ugly side effect?

NCT ID NCT06358677

Recruiting now Symptom relief Sponsor: University of Utah Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether a cream containing tretinoin (a form of vitamin A) can prevent or reduce the acne-like rash that often occurs in patients taking certain cancer drugs. About 25 adults with advanced solid tumors will apply the cream to one side of their face and a placebo cream to the other side, without knowing which is which. Researchers will compare the rash severity on both sides over time.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: topical tretinoin
What this could lead to: If it works, this could offer a simple way to manage a common and uncomfortable side effect of certain cancer treatments.
What could go wrong: This is a small, early-phase trial with only 25 participants, so results may not apply broadly. The treatment is tested only on the face and may cause skin irritation.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

metastatic malignant neoplasm neoplasm Neoplasm Metastasis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

LOCALLY ADVANCED SOLID TUMOR METASTATIC SOLID TUMOR

Contacts and locations

Locations

Huntsman Cancer Institute at University of Utah
RECRUITING

Salt Lake City, Utah, 84112, United States

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