University Of Utah

This study is testing if men with advanced prostate cancer that has spread can safely take planned breaks from their hormone-blocking drugs after their cancer is well-controlled. Researchers want to see if these treatment breaks reduce side effects like fatigue and hot flashes wh…

This study is testing if the drug metformin can help older adults rebuild muscle and strength after a period of not using a leg. Researchers want to see if taking metformin for two weeks during recovery improves muscle regrowth better than a placebo. The goal is to find a treatme…

This early-stage study is testing a personalized cell therapy called CAR-T for adults with certain blood cancers that have returned or not responded to at least two prior treatments. Doctors will collect a patient's own immune cells, genetically modify them to better target cance…

This study is testing a gentler, slower approach to starting treatment for very frail patients with multiple myeloma, a type of blood cancer. Researchers want to see if starting with two drugs and slowly adding a third helps patients stick with treatment longer and feel better. T…

This early-stage trial is testing new combinations of targeted drugs for people with melanoma skin cancer that has spread to the brain. It aims to see if these drugs can shrink brain tumors in patients whose cancer has continued to grow despite prior immunotherapy. The study will…

This study is testing if a drug called bortezomib, given as an injection, can help control advanced prostate cancer that has stopped responding to standard hormone treatments and has a specific genetic change called PTEN deletion. Researchers want to see if the treatment causes a…

This study is testing if a pill that boosts the body's natural sex hormones can help men heal better after surgery to repair a torn shoulder tendon. Men with low hormone levels will be randomly assigned to take either the real pill or a placebo (sugar pill) for several months aro…

This study is testing a shorter, lower-dose course of radiation therapy for people with HPV-linked throat cancer who have had robotic surgery. The main goal is to see if this approach can control the cancer while causing fewer side effects and improving patients' quality of life.…

This early-stage study is testing the safety and initial effectiveness of a two-drug combination (loncastuximab tesirine and rituximab) given after a precise form of radiation therapy. It is for adults with lymphoma that has spread to or started in the brain or spinal cord, parti…

This study is testing a combination of two immunotherapy drugs, nivolumab and axatilimab, for adults with classical Hodgkin lymphoma that has come back or hasn't responded to previous treatments, including similar immunotherapies. The main goals are to see if the combination is s…

This study aims to predict and prevent aggressive breast cancer from returning after initial treatment. Researchers will grow patients' tumor samples in mice and test drugs on them to create personalized treatment plans. If the cancer returns, doctors will use these test results …

This study is testing if a mindfulness training program and regular pain management visits with a doctor can help people who have long-term pain and take opioid painkillers. The goal is to see if these approaches can reduce pain, improve daily life, and lower the risks associated…

This study is testing the safety of adding a wearable medical device, called Tumor Treating Fields (TTFields), to the standard treatment for a specific type of advanced lung cancer. The device uses electric fields that may help stop cancer cells from growing. Researchers want to …

This study is testing whether a new oral drug, pirtobrutinib, works well when combined with the standard drug rituximab for adults newly diagnosed with marginal zone lymphoma, a type of slow-growing blood cancer. The main goal is to see how many patients' cancer shrinks or disapp…

This study is testing whether a two-drug treatment (loncastuximab tesirine and rituximab) can safely and effectively control cancer as a 'bridge' for patients waiting to receive a standard CAR-T cell therapy. It is for adults with large B-cell lymphoma that has returned or not re…

This early study is testing whether tiny electrode arrays implanted in the nerves of the arm can help people with amputations control a prosthetic hand more naturally. The goal is to record signals from the brain to move the hand and also send artificial touch and position sensat…

This study is testing a smartphone app designed to help parents of children with multiple, complex chronic illnesses. The app helps parents track key symptoms daily to spot early signs their child's health might be getting worse, with the goal of preventing emergency room visits …

This study is testing whether an AI system can learn to give personalized financial rewards to help people stick with a weight loss program. For 24 weeks, 80 adults with obesity will join a virtual group program, log their meals, and weigh themselves on a smart scale. The AI will…

This early-stage study is testing a combination of three drugs—tazemetostat, zanubrutinib, and an anti-CD20 antibody—for people with certain slow-growing B-cell lymphomas that have come back or stopped responding to prior treatments. The main goal is to find the safest and most e…

This study is testing a new self-help booklet designed to increase motivation to quit smoking in people recently diagnosed with specific cancers. Researchers want to see if the booklet is practical for patients to use and if they find it helpful. The study will also track if part…

This study is testing whether a daily pill called XL092 can help control advanced prostate cancer that has continued to grow despite previous radiation treatment. Researchers will check if participants' cancer has stopped progressing after 16 weeks of treatment and monitor side e…

This study is comparing a shorter course of internal radiation to the standard longer course for women with early-stage uterine cancer who have already had surgery. The main goal is to see if the shorter treatment works just as well at controlling the cancer while maintaining or …

This study is testing whether an oral drug called pemigatinib can help control two specific types of B-cell non-Hodgkin lymphoma that have come back or stopped responding to standard treatments. It is for adults with mantle cell lymphoma or marginal zone lymphoma who have already…

This study is testing whether a shorter 5-day radiation schedule works as well as the standard 9-day schedule for early-stage breast cancer. Researchers want to see if patients report similar satisfaction with their breast appearance and experience similar side effects. The trial…

This study is testing if giving two immunotherapy drugs (ipilimumab and nivolumab) before surgery can help control melanoma that has come back after a patient's initial treatment. About 25 adults with high-risk, operable melanoma that returned during or shortly after their last t…

This study aims to understand how two specific therapy skills help teens with a history of self-harm and suicide attempts. Researchers will teach 200 teens and a parent two different coping skills and track how often the teens use them in daily life using phone surveys. They will…

This study is testing whether text messages can help connect people with osteoarthritis to physical activity coaching. Researchers want to see if encouraging messages and a walking program help people manage their pain and stay active. The goal is to find better ways to deliver p…

This early-stage trial is testing the safety and initial effectiveness of combining two treatments for advanced prostate cancer that has spread and stopped responding to standard hormone therapy. The combination pairs a targeted drug (cabozantinib) with a radioactive therapy (177…

This study is testing if giving two different pneumonia vaccines in a series works better to protect people with chronic lymphocytic leukemia (CLL). CLL weakens the immune system, making patients very vulnerable to serious lung infections. Researchers want to see if this two-vacc…

This study is testing if a short educational video can help patients use fewer opioid painkillers after breast reconstruction surgery. Researchers will compare opioid use in patients who watch the video to those who receive standard care. The goal is to prevent long-term opioid d…

This study is testing if a digital chatbot can help women, especially from underserved communities, follow through with recommended breast cancer screening and follow-up care. It will enroll 2,700 women who recently had a mammogram. Half will receive usual care, and the other hal…

This study is testing whether a common vitamin called nicotinamide (a form of vitamin B3) can prevent new non-melanoma skin cancers in people who have chronic lymphocytic leukemia (CLL) and a history of these skin cancers. About 86 participants will take either the vitamin or a p…

This study is testing whether a non-medication, video-based therapy can reduce nightmares in adults with REM Sleep Behavior Disorder (RBD). Participants with RBD and a family member they live with will attend therapy sessions together via video conference. The goal is to see if t…

This pilot study is testing whether a personalized, home-based exercise program is practical and safe for people with stage II or III lung cancer who are undergoing combined treatments like chemotherapy and surgery. The program is delivered through telehealth and starts before tr…

This study is testing a new, lightweight motorized prosthetic leg for people with above-knee amputations. Researchers want to see if this powered leg helps people walk more easily, climb stairs, and perform daily tasks compared to their current prosthetic. The study will measure …

This study is testing whether acupuncture can help relieve the symptoms of Gulf War Illness, a complex condition affecting many veterans. 200 veterans with symptoms like fatigue, pain, and mood issues will receive personalized acupuncture treatments from experienced practitioners…

This study is testing whether wearing a special headband with embedded semiconductors can help reduce memory and thinking problems, often called 'chemo brain' or brain fog, in people with breast or gynecological cancers. Researchers will enroll 50 participants who have recently f…

This study is testing whether low-dose metformin, a common diabetes medication, can safely reduce the widespread pain, fatigue, and other symptoms of fibromyalgia. Researchers will compare metformin against a placebo pill in 72 adults with fibromyalgia to see if it helps by targe…

This study is testing whether a combination of brain, nerve, and hand stimulation can improve the connection between the brain and weakened hand muscles in people who have had a moderate-to-severe stroke. Researchers want to see if this approach can help improve hand movement and…

This study is testing a new, faster way to deliver radiation therapy to relieve pain from cancer that has spread to the bones. The goal is to treat patients in just one visit, without the usual planning scans, to see if it's a practical option. Researchers will enroll 40 adults t…

This study is testing whether a 12-week home exercise program can help reduce the severe fatigue that often comes with metastatic breast cancer treatment. Researchers will enroll 80 patients who are receiving Enhertu medication and experiencing fatigue. Participants will follow a…

This study is testing a home-based recovery program for people with lymphoma or myeloma who are undergoing CAR-T cell therapy. The program uses a tablet or smartphone to guide patients through personalized exercise, nutrition, and counseling plans from home. The main goal is to s…

This study is testing if a common acne cream (tretinoin) can prevent or reduce a severe, acne-like rash that is a common and painful side effect of certain cancer drugs. In a unique 'split-face' design, 25 adults with advanced solid tumors will apply the test cream to one side of…

This study is testing whether a new, non-invasive ultrasound device can help reduce pain and other symptoms of fibromyalgia. Researchers will enroll 50 adults with fibromyalgia who have not found relief from standard medications or physical therapy. Participants will wear a speci…

This study is following 10,000 people with common joint and tendon problems like arthritis, tennis elbow, and plantar fasciitis. All participants will receive an injection of platelet-rich plasma (PRP), which is made from their own blood. Researchers will track their pain levels,…

This study is testing if Swedish massage can help reduce symptoms of Generalized Anxiety Disorder (GAD) by changing how the brain works. Researchers will compare two groups: one receiving real massage and one receiving light touch, both twice a week for six weeks. They will use b…

This small pilot study is testing whether a non-invasive brain stimulation technique can reduce nerve pain caused by chemotherapy. Researchers will enroll 19 female breast or gynecologic cancer survivors who developed persistent nerve pain after treatment. Participants will recei…

This study is testing whether listening to brief guided meditation sessions during radiation therapy can help reduce anxiety for people with breast or gynecological cancers. It will compare the anxiety levels of patients who receive the meditation sessions to those who receive st…

This study is testing if guarana, a plant-based supplement, can help reduce severe fatigue in people with certain cancers. It will enroll 86 adults with neuroendocrine tumors or gynecologic cancers who report significant fatigue. Participants will take guarana or a placebo for se…

This study is testing whether an online group therapy program can help reduce chronic pain and improve quality of life for people with lupus who also have fibromyalgia. Researchers want to see if this emotional awareness therapy is safe and effective when delivered through video …

This study aims to understand how mindfulness meditation helps reduce chronic low back pain, especially for people taking opioid medications. Researchers will use brain scans and questionnaires to see how meditation changes the brain's response to pain. The goal is to learn more …

This study is testing whether a brief, 5-minute guided meditation played during radiation therapy sessions can help reduce anxiety for people with brain tumors. Researchers will compare the meditation group to patients receiving standard care (no meditation) to see if it makes a …

This study is comparing two different approaches for scheduling follow-up doctor visits after children are hospitalized for common infections like pneumonia or urinary tract infections. Researchers want to see if telling parents to schedule a visit only if needed works as well as…

This study is testing a new program designed to help injured children in Tanzania get emergency care faster. Researchers will work with local health centers and hospitals to identify what causes delays and then create a streamlined system for assessing and transferring patients. …

This early-stage study is testing a new device that uses focused sound waves guided by an MRI to heat and destroy part of a breast cancer tumor. The main goal is to see if the procedure is safe and tolerable. All participants will still have their standard surgery to remove the t…

This study aims to understand how the immune system and inflammation change as people get older. Researchers will compare 40 healthy younger adults (18-35) and older adults (65+) by taking blood samples and measuring physical strength. The goal is to gather information that could…

This study aims to understand why some premature babies develop a serious intestinal disease called necrotizing enterocolitis (NEC). Researchers will collect and analyze blood cells from premature and full-term babies to see how they respond to a specific substance linked to the …

This research study aims to understand how muscles recover after a period of inactivity, particularly comparing younger adults (18-35) and older adults (60-85). Participants will have one leg immobilized for two weeks, then undergo tests to measure muscle changes during recovery.…

This study aims to find the best way for clinics to offer at-home HPV self-test kits to women who are behind on their cervical cancer screening. Researchers will work with health centers to create and test a program that mails kits to eligible women and offers them in clinics. Th…

This study is testing a new decision support tool designed to help parents, children, and doctors make better, more informed choices about surgery for a severe type of scoliosis. It will compare the tool against usual care for 110 families to see if it improves decision quality a…

This study is testing whether small changes in how people are asked to join research can make them more likely to say yes. Researchers will send different versions of recruitment emails to 120 healthy adults to see which one works better. The goal is to learn how to improve volun…

This study aims to discover the specific genes and mutations that cause polycythemia (high red blood cells) and thrombocytosis (high platelets). Researchers will collect blood samples from 200 participants with these conditions to analyze their DNA. The goal is to identify the ge…

This study is testing a new educational video game designed to help teenagers with congenital heart disease learn the skills needed to manage their own healthcare as they transition from pediatric to adult care. The game teaches skills like talking to doctors, understanding medic…

This study aims to better understand how high-risk smoldering myeloma progresses over time. Researchers will follow 100 patients with this early-stage blood condition for two years using regular whole-body MRI scans and quality of life surveys. The goal is to learn when and how t…

This study aims to better understand a group of rare, inherited brain disorders called leukodystrophies. Researchers will follow 600 patients over time to learn how these diseases progress, improve diagnostic methods, and identify complications. The goal is to gather knowledge th…

This study aims to better understand how early-stage age-related macular degeneration (AMD) progresses toward vision loss. Researchers will follow 125 adults with early AMD using advanced eye scans and vision tests over time. The goal is to identify which patients are at highest …

This study aims to understand how sleep loss, combined with different patterns of light exposure and food intake, affects your body's metabolism and insulin sensitivity. Healthy adults aged 18-35 will stay overnight in a clinic three times to test different sleep and meal schedul…