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Can a new MRI scan reveal hidden tumor weaknesses?

NCT ID NCT06108089

Recruiting now Diagnosis Sponsor: University of Utah Source: ClinicalTrials.gov ↗

First seen Aug 05, 2026 · Last updated Aug 06, 2026 · Updated 1 time

Summary

This study is testing whether a special MRI technique can identify low-oxygen (hypoxic) regions within head and neck tumors. These areas are often resistant to treatment, so spotting them could help doctors personalize therapy. The trial will compare the MRI results with a standard PET scan and tissue samples to see if the new method is accurate. If it works, it might lead to more targeted and effective treatment plans for patients.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
Multiparametric hypoxia MRI (HMR) imaging, compared with [18F]FMISO-PET/CT and tissue samples
What this could lead to
If successful, this imaging approach could help doctors tailor radiation and chemo for head and neck cancer, potentially improving outcomes by targeting resistant tumor areas.
What could go wrong
This is a small, early-stage study (20 participants) focused on imaging accuracy, not treatment outcomes. The MRI technique may not reliably match the standard PET scans or biopsy results, and it won't directly test whether personalized treatment improves survival.

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Conditions

The condition(s) this trial relates to.

head and neck cancer Head and Neck Neoplasms head and neck squamous cell carcinoma Hypoxia malignant tumor of neck

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CANCER NECK HEAD AND NECK CANCER HYPOXIA MAGNETIC RESONANCE IMAGING

Contacts and locations

Locations

  • University of Utah

    RECRUITING

    Salt Lake City, Utah, 84112, United States

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