HYPOXIA

This study compares two drug combinations used for sedation during egg retrieval in fertility treatments. The goal is to see if remimazolam with alfentanil causes fewer episodes of low oxygen (hypoxia) than the standard propofol with alfentanil. About 400 women aged 18 to 50 will…

This study tests a redesigned breathing device that lets doctors switch between two types of airway support without extra tools. The goal is to keep oxygen levels stable and reduce breathing complications during general anesthesia. About 100 adults having planned surgery will tak…

This study tests whether a high-flow nasal cannula (a device that delivers warm, moist oxygen) can prevent dangerously low oxygen levels during sedated gastrointestinal endoscopy in people at high risk for obstructive sleep apnea. Researchers will enroll 600 adults with a STOP-Ba…

This study tests whether a high flow nasal cannula (a device that delivers oxygen through the nose) works better than a face mask for people with chest injuries who have low oxygen levels. About 100 participants will be randomly assigned to one of the two devices. The goal is to …

This study looks at whether not suctioning the breathing tube before removing it is safe and might reduce coughing and sore throat after surgery. About 408 adults having planned surgery will be randomly assigned to either routine suctioning or no suctioning. The main goal is to s…

This study tests a modified oxygen delivery method for people undergoing a lung procedure called bronchoscopy under deep sedation. The method uses a thin, flexible tube placed through the nose to deliver oxygen, aiming to prevent low oxygen levels (hypoxia) during the procedure. …

This study tests a new device called the COMBO Endoscopy Oropharyngeal Airway in 580 obese patients undergoing sedated gastrointestinal endoscopy. The device combines oxygen support, airway management, and monitoring to reduce the risk of low oxygen levels (hypoxia), a common com…

This study looks at whether strengthening your breathing muscles and taking nitrate supplements (like those found in beets) can help healthy adults exercise longer in low-oxygen conditions similar to high altitude. Researchers will measure how long participants can cycle before g…

This study looks at how blood vessels in the arm respond to low oxygen in women at different stages of menopause. Researchers will measure blood flow in 75 healthy women who are premenopausal, perimenopausal, or postmenopausal. No treatments or drugs are tested—the goal is simply…

This study looks at how the right side of the heart handles low oxygen, like at high altitudes. Healthy adults will breathe special gas mixtures to simulate altitudes of 2,500 and 4,000 meters, both at rest and during light exercise. The goal is to understand normal heart respons…

This study explores whether hypoxic conditioning—breathing air with less oxygen—can improve blood flow in the brains of inactive adults aged 60 to 80. Researchers will test this approach alone and combined with exercise training. The goal is to find new ways to preserve brain hea…

This study looks at whether low oxygen levels during sleep after hip fracture surgery are linked to delirium (sudden confusion) and other complications in patients over 70. Researchers will monitor oxygen overnight in 70 hospitalized patients. The goal is to better understand the…

This study looks at how being in a low-oxygen environment (like high altitude) affects mood and anxiety in people with depression or anxiety disorders, compared to healthy individuals. Participants spend six hours in a special chamber that simulates altitude, and researchers meas…

This study looks at how the right side of the heart handles low oxygen (like at high altitudes) in 18 adults who have previously had HAPE (high-altitude pulmonary edema). Participants breathe special gas mixtures to simulate altitudes of 2,500 and 4,000 meters while resting and d…

This study tests whether training ICU staff to keep oxygen levels in a specific range (90-96%) helps patients on breathing machines. Researchers will track how many days patients are free from the ventilator and how often dangerously low oxygen goes unnoticed. The goal is to impr…

This study aims to check how accurately common pulse oximeters measure blood oxygen levels in healthy people. Researchers will temporarily lower participants' oxygen levels in a controlled setting and compare the device readings to precise blood tests. The study will include 10,0…