HYPOXIA

This study tests a modified supraglottic airway device that lets doctors switch between mask and tube ventilation without using a catheter. The goal is to improve safety during general anesthesia. About 100 adults having planned surgery will take part.

This study tests whether a high-flow nasal cannula (a device that delivers warm, moist oxygen) can prevent low oxygen levels during sedated gastrointestinal endoscopy in people at high risk for obstructive sleep apnea. About 600 adults with a STOP-Bang score of 5 or higher will b…

This study tests a new way to give oxygen during a sedated lung scope (bronchoscopy). Normally, patients can have dangerously low oxygen levels because the scope and sedation block the airway. The new method uses a thin, flexible tube placed through the nose to deliver oxygen dir…

This study tests whether a sedative called remimazolam, combined with alfentanil, can lower the chance of low oxygen levels (hypoxia) during egg retrieval for IVF. About 400 women aged 18-50 will be randomly assigned to receive either remimazolam or the standard drug propofol. Th…

This study looks at whether not suctioning the breathing tube before removing it is safe and might reduce coughing and sore throat. About 408 adults having planned surgery will be randomly assigned to either routine suctioning or no suctioning. The main goal is to see if oxygen l…

This study tests a new device called the COMBO Endoscopy Oropharyngeal Airway in 580 obese patients undergoing sedated gastrointestinal endoscopy. The device combines oxygen delivery, breathing monitoring, and a bite block to prevent low oxygen levels. Researchers will compare it…

This study compares two breathing support methods for people with chest trauma who have low oxygen levels. One group gets a high flow nasal cannula, the other a standard oxygen mask. The goal is to see if the nasal cannula reduces the need for a breathing tube or pneumonia. About…

This study looks at how simulated high altitude (2,500 m and 4,000 m) affects the right side of the heart in people with well-controlled asthma. Eighteen participants will breathe special gas mixtures to mimic altitude while resting and doing light exercise. The goal is to learn …

This study looks at whether taking hot spring baths can help young athletes recover their thinking skills and physical performance while training at simulated high altitudes. Twenty-seven healthy teens who already train regularly will be randomly assigned to hot spring baths, pla…

This study tests whether training ICU staff to keep oxygen levels between 90-96% helps patients on breathing machines recover faster. Researchers will track how many days patients are free from the ventilator and how often dangerously low oxygen goes unnoticed. The goal is to imp…

This study explores whether mild low-oxygen (hypoxic) conditioning, alone or combined with exercise, can improve blood vessel function in the brains of inactive adults aged 60-80. Researchers will measure changes in brain blood flow and other health markers in 64 participants. Th…

This study looks at whether low oxygen levels during sleep after hip fracture surgery are linked to delirium (sudden confusion) in patients over 70. Researchers will monitor 70 participants in the hospital to see if nighttime hypoxia increases the risk of complications like infec…

This study looks at how the right side of the heart works when there is less oxygen, like at high altitudes. It involves 18 adults who have had HAPE (high-altitude pulmonary edema) in the past. Participants breathe special gas mixtures to mimic altitudes of 2,500 and 4,000 meters…

This study looks at how the right side of the heart works when oxygen levels drop, like at high altitudes. Healthy volunteers will breathe special gas mixtures that mimic altitudes of 2,500 and 4,000 meters, both at rest and during light cycling. The goal is to create a baseline …

This study looks at how low oxygen levels (like at high altitudes) affect mood and anxiety in people with depression or anxiety disorders compared to healthy individuals. 68 participants will spend six hours in a special chamber that simulates 3,800 meters altitude, and their fee…

This study tests whether strengthening your breathing muscles with a handheld device and taking nitrate supplements (like those in beetroot juice) can improve exercise performance in simulated high altitude. Eighty healthy adults will train for 4-6 weeks and then do a cycling tes…

This study examines how aging and menopause change the way blood vessels widen in response to low oxygen. Researchers will give healthy women either a placebo, a beta-blocker (propranolol), or a bladder medication (gemtesa) to see how these drugs affect blood flow in the forearm.…

This study checks how well pulse oximeters measure blood oxygen during mild to severe low oxygen levels in 10,000 healthy adults aged 18-50. Researchers compare the device's reading to a precise blood test, and also look at how skin pigmentation affects accuracy. The goal is to m…