HYPOXIA

This study tests whether a newer sedative, remimazolam, combined with alfentanil, can lower the chance of low oxygen levels (hypoxia) during egg retrieval for IVF. About 400 women aged 18-50 will be randomly assigned to receive either remimazolam or the standard drug propofol. Th…

This study tests whether a high flow nasal cannula (a device that delivers warm, moist oxygen through the nose) works better than a standard face mask for people with chest injuries who have low oxygen levels. About 100 participants will be randomly assigned to one of the two dev…

This study tests a redesigned breathing tube (supraglottic airway) that lets doctors switch between two types of ventilation without extra tools. The goal is to keep oxygen levels stable and avoid breathing complications during general anesthesia. About 100 adults having planned …

This study tests a modified oxygen delivery method for people undergoing a lung procedure called bronchoscopy under deep sedation. The method uses a thin, flexible tube placed through the nose to deliver oxygen, aiming to prevent low oxygen levels (hypoxia) during the procedure. …

This study tests whether a high-flow nasal cannula (a device that delivers warm, moist oxygen through the nose) can prevent low oxygen levels during sedated gastrointestinal endoscopy in people at high risk for obstructive sleep apnea. About 600 adults with a STOP-Bang score of 5…

This study tests a new device called the COMBO Endoscopy Oropharyngeal Airway in 580 obese patients undergoing sedated gastrointestinal endoscopy. The device combines oxygen support, airway management, and monitoring to reduce the risk of low oxygen levels (hypoxia), a common com…

This study looks at how being in a low-oxygen environment (like high altitude) affects mood and anxiety in people with depression or anxiety disorders, compared to healthy individuals. Participants spend six hours in a special chamber that simulates altitude, and researchers meas…

This study looks at whether skipping the step of suctioning the breathing tube before removing it is safe and might even be better for patients. About 408 adults having planned surgery will be randomly assigned to either receive routine suctioning or no suctioning. The main goal …

This study looks at whether strengthening your breathing muscles and taking a nitrate supplement (like the stuff in beets) can help healthy adults exercise longer in conditions that mimic high altitude. 80 recreationally active people aged 18-40 will do cycling tests before and a…

This study looks at how the right side of the heart handles low oxygen (like at high altitudes) in 18 adults who have previously had HAPE (high-altitude pulmonary edema). Participants breathe special gas mixtures to simulate altitudes of 2,500 and 4,000 meters while resting and d…

This study tests whether training ICU staff to keep oxygen levels in a specific range (90-96%) helps patients on breathing machines. Researchers will track how many days patients are free from the ventilator and how often dangerously low oxygen goes unnoticed. The goal is to impr…

This study looks at whether low oxygen levels during sleep after hip fracture surgery are linked to delirium (sudden confusion) in people over 70. Researchers will monitor 70 patients in the hospital for at least 5 nights. The goal is to understand if nighttime oxygen problems in…

This study looks at whether breathing low-oxygen air (hypoxic conditioning), either by itself or combined with exercise, can improve blood vessel health in the brains of older adults. Researchers will enroll 64 inactive people aged 60 to 80 to test this approach. The goal is to f…

This study looks at how a healthy heart, especially the right side, reacts when there is less oxygen in the air, like at high altitudes. 18 healthy adults will breathe special gas mixtures that mimic altitudes of 2,500 and 4,000 meters, both at rest and during light exercise. The…

This study looks at how blood vessels widen in response to low oxygen in women who are premenopausal, perimenopausal, or postmenopausal. Researchers will measure blood flow in the forearm to understand the role of certain receptors. The goal is to learn more about vascular change…

This study aims to check how accurately common pulse oximeters measure blood oxygen levels in healthy people. Researchers will temporarily lower participants' oxygen levels in a controlled setting and compare the device readings to precise blood tests. The study will include 10,0…