University Of Utah

This early-stage trial is testing the safety and best dose of a three-drug combination for patients with advanced bladder cancer that has spread or cannot be removed by surgery. The treatment combines two immunotherapy drugs that help the immune system fight cancer with a third d…

This study is testing whether a drug called enfortumab vedotin, given alone or with other cancer drugs, can help control advanced prostate cancer that has spread and no longer responds to standard hormone therapies. It is for men whose cancer has progressed despite prior treatmen…

This study tests whether a customized hospital program can reduce unnecessary antibiotic prescriptions when patients leave the hospital. Researchers will work with 40 Michigan hospitals to create tailored plans for improving antibiotic use for pneumonia and urinary tract infectio…

This study is testing if a 30-minute educational website can help people who stopped taking their cholesterol-lowering statin pills due to muscle aches. Researchers want to see if using the website makes people more likely to try the medication again with their doctor and stick w…

This study is testing whether a combination of surgery and radiation can control prostate cancer that has returned or spread to a few other places in the body. It involves 20 men whose cancer has come back after initial treatment. The goal is to see if this targeted approach can …

This study is testing a new way to perform total shoulder replacement for severe arthritis. The new technique avoids cutting a key shoulder muscle (the subscapularis), which is normally cut and repaired in standard surgery. Researchers will track 50 patients to see if this muscle…

This early-stage study is testing the safety of combining two drugs, nivolumab and Radium-223, for men with advanced prostate cancer that has spread to the bones and is no longer responding to standard hormone therapy. The goal is to see if this combination is safe and shows earl…

This study is testing if changing the order of two standard treatments—chemotherapy and immunotherapy—can improve results for people with advanced non-small cell lung cancer that has spread. It will compare two schedules: one where chemo is given a week before the immunotherapy, …

This study is testing if using two surgical implants instead of one is better for older adults who break their thigh bone near the knee. The goal is to see if the two-implant method allows patients to get up and walk sooner, which could help them live longer and avoid complicatio…

This study looks back at the three-year results of a combined glaucoma surgery. Researchers are checking if using two different minimally invasive techniques together during cataract surgery works better than cataract surgery alone to lower eye pressure. They will review the reco…

This study is testing two different ways to help rural communities run a proven family program for managing childhood obesity. Researchers are comparing a basic online resource package to the same package plus extra group coaching for community teams. The goal is to see which app…

This study is testing a year-long program designed to help young adults (ages 18-24) better manage their type 1 diabetes. The program involves monthly phone coaching and daily text messages to help participants set and meet diabetes goals, and they can optionally invite a friend …

This study is testing if the drug cobimetinib can help control a specific type of blood cancer called Chronic Myelomonocytic Leukemia (CMML) in adults. It is for people who are newly diagnosed or whose previous treatment has stopped working, and whose cancer has specific genetic …

This study is testing if a common, safe diabetes medication called metformin can help older adults rebuild muscle and regain strength after hip fracture surgery. Researchers will give 60 patients either metformin or a placebo pill daily for four months after their operation to se…

This study is testing if adding a drug called nivolumab (an immunotherapy) after standard chemotherapy and radiation treatment helps keep bladder cancer from returning. It is for 200 adults with muscle-invasive bladder cancer who are not candidates for or refuse major surgery to …

This study is testing a new program to help more people at risk for lung cancer get screened. It uses text messages, videos, and telehealth calls to guide patients through the screening process and help them overcome common barriers like confusion or scheduling. The goal is to se…

This study is testing a new, culturally tailored program designed to help Spanish-speaking adults at risk for diabetes prevent the disease. The program, called 'Paso a Paso,' focuses on lifestyle changes like healthy eating and physical activity to promote weight loss. Researcher…

This study tests different reminder systems to help parents in rural areas get their children (ages 9-17) vaccinated against HPV, a virus that can cause cancer. Researchers are comparing automated reminders (like texts or calls), automated reminders plus live calls from clinic st…

This early-stage study is testing if the diabetes medication metformin can help prevent muscle loss and insulin resistance in healthy adults aged 60+ during short periods of bed rest. Researchers want to see if taking metformin before and during five days of bed rest can protect …

This study is testing whether a special plastic sleeve placed around the surgical wound during shoulder replacement can reduce bacterial contamination and prevent serious joint infections. Researchers are comparing patients who receive the wound protector with those who don't dur…

This is a small, early-stage study to see if a drug called memantine is safe and might help people recover movement in their arms and legs after a recent stroke. Twenty participants with arm weakness from a stroke will be randomly assigned to receive either the drug or a placebo …

This study is testing an 8-week online program designed to help couples cope with the emotional challenges after a stroke. It involves 400 participants (200 couples) where one partner had a stroke 3 months to 3 years ago. The program teaches skills like communication, gratitude, …

This study is testing if a wearable device called a 'Shoulder Pacemaker' can help people recover better after a major shoulder replacement surgery. The device uses gentle electrical stimulation to help retrain the muscles around the shoulder blade. Researchers will compare recove…

This study aimed to see if giving a single dose of methadone during breast reconstruction surgery could provide longer-lasting pain relief. The goal was to reduce the total amount of opioid painkillers patients need after their operation, which could lower the risk of side effect…

This study aims to see if a newer type of surgical screw, called the Bone Bolt®, provides better pain relief after surgery for a common pelvic fracture compared to standard screws. It will involve 100 adults with this specific injury. Researchers will measure pain levels after su…

This study is testing whether a drug called budesonide can prevent or reduce severe diarrhea in people with multiple myeloma who are undergoing a stem cell transplant. About 120 participants will be randomly assigned to receive either budesonide or a placebo, in addition to their…

This study is testing whether a specific type of ultraviolet light treatment (UVA-1) can improve symptoms and daily life for people with conditions that cause skin hardening, like scleroderma and morphea. Researchers will give 30 light therapy sessions to 30 participants and meas…

This research aims to improve bone healing after spine fusion surgery by studying patients' own tissue. Researchers will analyze a small piece of bone graft taken during a patient's scheduled back surgery to identify which cells are most efficient at forming new bone. The goal is…

This study is developing and testing a new computer tool to help pharmacists identify and reduce risks when dispensing opioid pain medications. The research involves 80 pharmacies in Ohio, where some will use the new risk assessment tool while others follow standard procedures. T…

This University of Utah study investigates whether massage therapy reduces anxiety by changing brain activity. Researchers will compare Swedish massage to light touch therapy in 46 healthy adults over 8 weeks. Participants will undergo brain scans before and after treatment to me…

This study aims to understand how massage affects the brain and body. Researchers will use brain scans to compare how Swedish massage versus light touch therapy changes brain activity, heart rate, and stress levels in healthy adults. Participants receive one session while researc…

This study is testing a surprising idea: that a specific type of blood vessel growth in the eye might actually help protect vision in people with age-related macular degeneration (AMD), rather than harm it. Researchers are closely watching 73 participants with this specific vesse…

This study is checking how well a specific new hip replacement stem fits into the thigh bone over several years. Researchers will look at X-rays from 100 patients who received this implant to see if it stays securely in place. The goal is to gather information on the implant's pe…

This study is testing a web-based decision aid designed to help parents who must make urgent, life-altering choices for a fetus or newborn diagnosed with a severe, life-threatening heart defect. Researchers are comparing parents who use the tool to those who don't, to see if it r…

This study aims to understand how physically demanding orthopaedic surgery is for surgeons. Researchers will measure heart rates and other body signals from surgeons during operations using special smart vests. The goal is to gather data about the physical stress surgeons experie…

This study aimed to understand if a specific type of immune cell (T cells) causes arteries to stiffen and function poorly as people age. Researchers planned to test this by giving an existing arthritis drug, Abatacept, to healthy older adults to see if it improved artery health. …

This study aims to understand how the placement of tiny stents during glaucoma surgery affects long-term eye pressure control. Researchers are observing 116 adults who previously had combined cataract and stent surgery at the Moran Eye Center. They will check stent position with …

This study aims to find out if certain genes make some people more likely to get serious infections after hip or knee replacement surgery. Researchers are enrolling 150 participants from families where these infections have occurred. By comparing genetic samples, they hope to ide…

This study aims to find out if certain parts of walking boots can be safely cleaned and reused for different patients recovering from foot or ankle injuries. Researchers will enroll 60 patients to check for skin problems and see how many times boot parts can be reused before they…

This study is testing whether advanced MRI scans can be safely used during surgery to remove brain tumors called gliomas. Researchers want to see if these special scans are practical to perform in the operating room and if they help link different parts of the tumor to specific b…

This study aims to understand how a hip condition called femoroacetabular impingement (FAI) affects joint movement. Researchers will compare motion patterns in 36 people with FAI to those without the condition. The goal is to gather information that could help doctors better diag…

This study aims to understand how sleep and daily routines affect the health of couples where one partner has mild memory problems. Researchers are observing 170 couples over time to see if sleep patterns influence memory changes and well-being in both partners. The goal is to le…