University Of Utah

This early-phase trial is testing a combination of two drugs, loncastuximab tesirine and rituximab, as a first treatment for a rare blood cancer called post-transplant lymphoproliferative disorder (PTLD) that can occur after an organ transplant. The study will first find the safe…

This study investigates whether metformin, a widely used diabetes medication, can help muscles recover better after anterior cruciate ligament (ACL) reconstruction surgery. The trial enrolls adults aged 40 and older with a full ACL tear who are scheduled for surgery. Participants…

This early-phase study tests whether adding the drug ropeginterferon alfa-2b to the standard treatment ruxolitinib is safe for people with myelofibrosis, a type of bone marrow cancer. About 15 adults already on a stable dose of ruxolitinib will receive the combination. The main g…

This early-stage study tests whether high-dose Vitamin C is safe for people with two rare inherited blood disorders—Pyruvate Kinase Deficiency (PKD) and a form of G6PD deficiency. Both conditions cause red blood cells to break down too quickly, leading to anemia. The study will e…

This phase II trial is testing the safety and effectiveness of combining two drugs, mosunetuzumab and pirtobrutinib, in 25 adults with relapsed or refractory Waldenstrom Macroglobulinemia, a rare blood cancer. Participants must have had at least one prior treatment. The study aim…

This study looks at whether estradiol patches can improve shoulder healing after rotator cuff repair in post-menopausal women. About 58 women will receive either an estradiol patch or a placebo patch for three months after surgery. The goal is to see if the hormone helps reduce p…

This study compares two emergency contraception pills: levonorgestrel plus piroxicam (an anti-inflammatory drug) versus levonorgestrel alone. About 1,458 women aged 16-35 who had unprotected sex within 72 hours will participate. The goal is to see if adding piroxicam reduces preg…

This study aims to see if a new blood test can accurately detect lung cancer by analyzing RNA from platelets. Researchers will collect blood samples from 240 adults with lung cancer or suspicious lung nodules. The goal is to validate whether this AI-powered test can distinguish b…

This study aims to find the best ways to increase lung cancer screening among current and former smokers aged 50-80 in community health centers. About 19,000 participants will receive text messages and clinic support to complete eligibility checks and low-dose CT scans. The goal …

This pilot study will test whether having a paracentesis (draining fluid from the belly) at home can improve symptoms in 20 women with cancer-related malignant ascites. Participants will have the procedure at home, and researchers will measure symptom changes using a simple surve…

This study will test a new multilingual chatbot called LIFT-UP designed to help people living in poverty quit smoking. Researchers will interview 22 adults who smoke at least 3 cigarettes daily and are motivated to quit. The goal is to see if the chatbot is easy to use and helpfu…

This study tests whether a program called Waning Moon is practical and well-liked by urban American Indian and Alaska Native women going through menopause. The program includes four weekly group sessions led by community health workers, covering menopause education, mindfulness, …

This study tests whether a short mindfulness exercise, followed by questions that help patients reflect on their experience, can reduce pain and anxiety after knee or hip replacement surgery. Adults who have had a joint replacement will receive a guided breathing exercise via tex…

This study explores whether a non-invasive, painless skin measurement called electrical bioimpedance can help monitor acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS). About 25 adults who are already scheduled for a bone marrow biopsy will also receive this skin te…

This large study tests whether using electronic health records and text messages can help more adults with obesity enroll in proven weight-loss programs. Over 5,000 patients from community health centers will be invited to join. The goal is to see if simple clinic prompts and fol…

This study tests whether a short educational presentation about radon can improve knowledge and encourage testing among cancer survivors, their caregivers, and family members. Participants attend a single session, either in person or online, led by a study staff member. The goal …

This study tests an AI-powered chatbot that automatically creates personalized survivorship care plans for adult cancer survivors. The chatbot uses information from electronic health records to generate a plan and answer patients' questions about it. Researchers want to see if th…

This study tests a communication tool called the FOCUS Guide. It is designed to help older adults (age 65 and up) and their surgeons talk about the goal of surgery during clinic visits. The study will see if using the guide leads to more discussions and documentation of surgery g…

This study tests a new chatbot designed to help cancer patients and their caregivers in rural areas find clear information about insurance, travel costs, and other financial aspects of cancer care. About 60 participants will be randomly assigned to use either a hybrid chatbot or …

This study will test three ways of giving oxygen to 280 adults during colonoscopy sedation: standard continuous flow, breath-synchronized pulses via the Sovant device, and CPAP. Researchers will track how often patients have breathing pauses or low oxygen levels. The goal is to f…

This study will test a new breathing support system in 25 healthy volunteers. The goal is to see how accurately the system measures breath volume, rate, and carbon dioxide levels, and how comfortable it is to use. This is not a treatment study—it aims to gather information to imp…

This study tests whether a new educational tool helps patients on blood thinners (anticoagulants) better understand their medication. About 68 adults who are new to or currently taking these drugs will use either the new materials or standard ones and then answer surveys. The mai…

This study will test different ways to give rural tribal members their personal environmental exposure results, like radon and indoor air pollution. About 112 participants will have monitors installed in their homes and then receive feedback in various formats and from different …