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Could a common diabetes drug help muscles heal faster after ACL surgery?

NCT ID NCT07699367

Not yet recruiting Disease control Sponsor: University of Utah Source: ClinicalTrials.gov ↗

First seen Jul 13, 2026 · Last updated Jul 14, 2026 · Updated 1 time

Summary

This study investigates whether metformin, a widely used diabetes medication, can help muscles recover better after anterior cruciate ligament (ACL) reconstruction surgery. The trial enrolls adults aged 40 and older with a full ACL tear who are scheduled for surgery. Participants take metformin or a placebo daily for four months after surgery, and researchers measure muscle scarring, inflammation, and leg strength to see if metformin improves recovery.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
Metformin
What this could lead to
If it works, this could point toward a simple, inexpensive way to speed muscle recovery and improve leg strength after ACL surgery.
What could go wrong
This is a very early, small trial with only 40 participants. Metformin may not reduce muscle scarring or improve strength, and it can cause gastrointestinal side effects.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Atrophy Inflammation inflammatory disease Muscle Weakness

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ATROPHY INFLAMMATION WEAKNESS, MUSCLE

Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • University of Utah

    Salt Lake City, Utah, 84112, United States

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