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Could a common diabetes drug help muscles heal faster after ACL surgery?

NCT ID NCT07699367

Disease control Sponsor: University of Utah Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jul 13, 2026 · Last updated Jul 14, 2026 · Updated 1 time

Summary

This study investigates whether metformin, a widely used diabetes medication, can help muscles recover better after anterior cruciate ligament (ACL) reconstruction surgery. The trial enrolls adults aged 40 and older with a full ACL tear who are scheduled for surgery. Participants take metformin or a placebo daily for four months after surgery, and researchers measure muscle scarring, inflammation, and leg strength to see if metformin improves recovery.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Metformin
What this could lead to
If it works, this could point toward a simple, inexpensive way to speed muscle recovery and improve leg strength after ACL surgery.
What could go wrong
This is a very early, small trial with only 40 participants. Metformin may not reduce muscle scarring or improve strength, and it can cause gastrointestinal side effects.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Early phase 1

The earliest testing in people: a first look at safety, in a very small group.

Participants

About 40 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Nov 2026

An estimate. Start dates often move.

Expected to finish

Oct 2032

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

40 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Age between 40y and older 2. BMI: \<30 kg/m2 3. Full thickness ACL tear 4. Less than 6 months between ACL injury and scheduled ACLR Exclusion Criteria: 1. Prior ACL tear in limb scheduled for reconstruction or current bilateral ACL tear 2. Total knee dislocation 3. Anticipated quadriceps ACLR grafts 4. Current infection near the lower limb 5. Inability to attend physical therapy sessions 6. Post-operative loading restrictions 7. History of cardiovascular disease (e.g., CHF, CAD, MI, CVA) 8. History of endocrine or metabolic disease such as hypo/hyperthyroidism and diabetes (Treated hypo/hyperthyroid for at least 6 months will be permitted) 9. History of stroke with motor disability 10. History of respiratory disease (acute upper respiratory infection, history of chronic lung disease) 11. Self-reported pregnancy 12. Bleeding disorder 13. Implanted electronic devices (e.g., pacemakers, electronic infusion pumps, stimulators) 14. Cancer or history of successfully treated cancer (less than 1 year) other than basal cell carcinoma 15. Chronic systemic corticosteroid use (≥ 2 weeks) within 4 weeks of enrollment and for study duration (intra-articular/topical/inhaled therapeutic or physiologic doses of corticosteroids will be permitted) 16. Androgens or growth hormone within 6 months of enrollment and for study duration (topical physiologic androgen replacement will be permitted) 17. Currently taking estrogen products (topical estrogen products will be permitted) 18. Taking anticoagulant medication (warfarin/Coumadin, heparin) that may complicate the muscle biopsy 19. Any staff members who report directly to the principal investigators

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Conditions

The condition(s) this trial relates to.

Atrophy Inflammation inflammatory disease Muscle Weakness

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Atrophy Inflammation Weakness, muscle

How to take part

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  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • University of Utah

    Salt Lake City, Utah, 84112, United States

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