University Of Utah

This study tested whether using a wound protector during shoulder replacement surgery lowers the chance of bacterial contamination. One hundred patients were randomly assigned to receive surgery with or without the device. The goal was to see if the protector reduces deep wound b…

This study tested whether doing balance exercises 3 times a week for 4 weeks works as well as doing them 2 times a week for 6 weeks in people with chronic ankle instability. 57 adults with weak, unstable ankles were randomly assigned to one of the two training groups or a waitlis…

This study tested whether combining brain stimulation, nerve stimulation, and hand exercises can help people with chronic stroke regain hand movement. Fifty-one participants who had a stroke at least six months prior received the combined therapy. The goal was to see if it streng…

This early-phase trial tested a combination of two drugs (MEK162 and mFOLFIRI) in 25 adults with advanced RAS-positive colorectal cancer that had stopped responding to standard treatment. The main goal was to find the safest dose and check for side effects. Researchers also looke…

This pilot study tested whether the cholesterol drug atorvastatin, followed by misoprostol, can safely and effectively end an early pregnancy. Nine participants at 35-49 days of pregnancy took atorvastatin daily for a week, then misoprostol. Researchers used ultrasounds and blood…

This study looked at whether a fast blood test (ROTEM) done during surgery for placenta accreta can help doctors decide when to give blood transfusions. 32 women took part, with half getting the rapid test and half getting standard lab tests. The goal was to see if the rapid test…

This early study tested whether placing a thin layer of human amniotic membrane on the heart during bypass surgery could reduce inflammation and prevent post-operative atrial fibrillation (an irregular heartbeat). Twenty-seven patients were randomly assigned to receive either the…

This study tested a cream containing acyclovir and penciclovir against an over-the-counter cream (Abreva) for preventing cold sores caused by UV light. Forty adults with a history of cold sores were exposed to UV light to trigger an outbreak, then treated with one of the creams. …

This phase II trial tested a 9-day course of whole breast radiation (hypofractionated radiotherapy) in 102 patients with early-stage breast cancer (stage 0-IIB). The goal was to see if a shorter treatment time could maintain effectiveness while reducing side effects. Researchers …

This study tested whether EDTA eye drops can shorten cold sore outbreaks compared to the over-the-counter cream Abreva. Ten adults with a history of sun-triggered cold sores were randomly assigned to one of the two treatments. Researchers tracked how many days it took for each co…

This study tested whether lifestyle coaching delivered through a patient portal helps adults maintain weight loss. 269 participants who had already lost at least 5% of their body weight were randomly assigned to receive either coaching plus tracking tools or tracking tools alone …

This study tested a brief counseling program delivered by pharmacists to help people who take prescription opioids and also drink alcohol. The program combined medication review with motivational interviewing to encourage safer use. Researchers enrolled 112 adults and measured ch…

This pilot study tested whether giving the blood thinner enoxaparin after a C-section is feasible and safe. 64 women who had a C-section were randomly assigned to receive enoxaparin or no treatment for 14 days. The main goal was to see if enough women would join and complete the …

This study tested whether a diode laser can act as a biomarker to measure neuropathic pain in people with peripheral neuropathy. Researchers compared pain responses to a lidocaine patch versus a placebo patch in 75 participants. The goal was to see if the laser test could disting…

This completed study tested a tool called MyLungHealth, delivered through a patient portal, to help more people get screened for lung cancer. Over 31,000 participants aged 50-79 with a smoking history were involved. The tool aimed to identify who was eligible for screening and en…

This study tests a program called FLARE that teaches families how to protect children from the sun. It includes children ages 8 to 17 who have a parent who survived melanoma and who have had at least one sunburn in the past year. Families are randomly assigned to either the FLARE…

This pilot study tested different outreach methods—like automated calls, texts, and emails—to encourage parents in rural areas to get their children (ages 9-17) the HPV vaccine. The study involved 335 parents and caregivers at four community clinics in rural Washington. The main …

This early-phase study tested whether a hormone called progesterone could help new mothers avoid returning to methamphetamine use after childbirth. 34 postpartum women with a history of meth use but currently abstinent took either progesterone or a placebo for 12 weeks. The goal …

This completed study tested a school-based educational program to improve sun protection among 38 rural Utah high school students. The program included a 90-minute session with skin cancer education, a risk self-assessment, and creating a personal sun protection plan. Surveys mea…

This study tested two practical methods to increase COVID-19 vaccination among over 65,000 patients at Utah community health centers. One group received text message reminders to get vaccinated, while another group got texts plus a personal navigator to help with logistics like s…

This study tested whether a mindfulness-based training program could help adults who had lost weight keep it off. 48 participants, including those who had bariatric surgery or lost weight through medical or lifestyle programs, took part. The goal was to see if focusing on eating …

This study tested a program called SHINE to help high school students use more sun protection and tan less. Over 2,200 students from 30 schools in Utah took part. Half the schools got the SHINE program, and the other half got standard lessons. The goal was to see if the program c…

This study tested whether a single injection of platelet-rich plasma (PRP) into the hip joint can relieve pain and improve function in people with a torn hip labrum. Thirty adults aged 18 to 49 who had not improved with standard care received the injection. Researchers tracked th…

This study tested whether a personalized exercise program helps people with early-stage lung cancer or cancer that spread to the lungs recover better after surgery. 182 participants were randomly assigned to either the exercise program or usual care. The main goal was to see if t…

This study tested whether a low-cost version of platelet-rich plasma (PRP) injections could safely ease joint pain and swelling in people with bleeding disorders like hemophilia. Fourteen adults with joint damage received the injection and were followed for 6 months. The goal was…

This study tested a program called EnACT for family caregivers of people with dementia. The program uses group sessions where caregivers watch scenarios, practice responses, and reflect on their choices. The goal is to help caregivers feel more prepared and less stressed when dea…

This study looked at whether taking a whey protein supplement twice a day helps adolescent soccer players improve their performance, recover faster, and change body composition during a 10-12 week competitive season. Thirty-one high school players aged 13-18 took either the prote…

This study tested a device that sends sound from the non-hearing ear to a cochlear implant in the other ear. 16 older adults with one cochlear implant used the device to see if it improved their speech understanding in noisy settings. The goal was to also see if it improved quali…

This study compared two injections for sacroiliac joint pain: platelet-rich plasma (PRP) made from the patient's own blood, and a standard steroid/anesthetic mix. Fifty adults with confirmed sacroiliac joint pain received one of the two injections. Researchers measured pain level…

This study compared a single injection of sterile amniotic fluid to the standard steroid shot for knee osteoarthritis. 60 adults with moderate knee arthritis who had not gotten relief from other treatments took part. The main goal was to see if the amniotic fluid could reduce the…

This study tested a drug called dexmedetomidine in 50 newborns with brain injury who were undergoing cooling therapy. The goal was to see if it could provide sedation and pain relief as well as morphine, but with fewer risks. Researchers measured safety and drug levels in the blo…

This study tested different treatment sequences for chronic low back pain in 749 adults. Participants first received either physical therapy or cognitive behavioral therapy. Those who didn't improve were switched to the other therapy or added mindfulness. The goal was to find whi…

This study tested whether exercise, with or without internet-based cognitive behavior therapy, could reduce fatigue in 126 men with advanced prostate cancer. Participants were on hormone therapy and followed a 12-week exercise program. The goal was to see if these non-drug approa…

This study tested whether a medicated cloth (glycopyrronium) could reduce excessive sweating at the amputation site in 13 limb amputees. Participants used either the active cloth or a placebo for four weeks, then switched after a washout period. The goal was to see if less sweati…

This pilot study tested whether radiofrequency ablation (RFA) of the genicular nerves can reduce chronic knee pain in people who had a total knee replacement at least a year ago. Five participants with moderate to severe pain received the procedure. The goal was to see if RFA pro…

This pilot study tested a new behavioral treatment called Emotional Awareness and Expression Therapy (EAET) for people with migraines. Thirty adults with frequent migraines were randomly assigned to either EAET or a control group. The therapy involved 8 weekly online sessions whe…

This study tested a low-cost way to make platelet-rich plasma (PRP) from a patient's own blood for knee osteoarthritis. Twenty adults with mild to moderate knee OA received two injections of this homemade PRP. The main goal was to see if the PRP had enough platelets, similar to e…

This study tested whether Reiki, a hands-off energy therapy, or mindfulness meditation can reduce pain and stiffness in people with knee osteoarthritis. 164 adults were randomly assigned to receive Reiki, sham Reiki, mindfulness meditation, or no treatment for four weekly session…

This study tested whether an injection of amniotic fluid, a natural anti-inflammatory, works better than a standard steroid injection for chronic back and leg pain caused by spinal stenosis. Sixty-one adults who had not improved with other treatments were randomly assigned to rec…

This study tested whether an educational website helps people who stopped taking statins due to muscle pain make informed decisions about restarting. Nearly 900 participants were randomly assigned to use the website or receive usual care. The goal was to see if the website increa…

This study looked at how lifestyle factors like obesity and muscle loss affect kidney cancer risk and survival after kidney removal. Researchers collected blood, tissue, and questionnaire data from 161 patients over up to 5 years. The goal was to understand how to personalize tre…

This study tested whether a daily probiotic supplement could support emotions, thinking skills, and immune function in 104 adolescents with moderate stress. Participants took either probiotics or a placebo for 12 weeks. Researchers measured mood, memory, attention, and immune mar…

This study looked at 38 adults who usually sleep less than 6 hours a night. Researchers helped them increase their sleep to the recommended 7 hours and measured changes in blood chemicals and insulin sensitivity. The goal was to find biological markers that can tell if someone is…

This study checked how accurately a practitioner can locate a rib by touch (palpation) compared to using ultrasound. 44 healthy adults took part. The goal was to see if palpation alone is reliable enough for dry needling of deep shoulder muscles. Results help guide safer practice…

This study looked at whether cochlear implants, which help restore hearing, can also improve thinking and memory in adults aged 65 and older with hearing loss. Researchers gave 37 participants a series of cognitive tests before surgery and again at 6 months, 12 months, and 5 year…

This study tested whether a new software program helps doctors more accurately interpret ROTEM blood clotting tests. Twenty-six doctors and residents from the University of Utah took part. Researchers compared their answers before and after using the software to see if it improve…

This study looked at how hormonal birth control might help manage inflammatory bowel disease (IBD) symptoms that get worse during a woman's period. Researchers surveyed 50 women with IBD to understand their preferences for birth control and whether they would join a future trial.…

This study tested whether sending text messages can help more people get screened for lung cancer. 65 adults aged 50-80 who were current or former smokers took part. The program used a central system to check who was eligible, offer risk assessments, and help schedule screening. …

This study looked at 270 women who had unprotected sex and then started a highly effective birth control method (like an IUD or implant) 6 to 14 days later. The goal was to find out how many got pregnant in the first month. The results help doctors and patients understand the ris…

This study tested how different social media messages influence people's plans to get screened for colorectal cancer. Over 2,000 participants completed a 15-minute survey after seeing one of several message types. The goal was to see which messages made people more likely to foll…

This study looked at how to best communicate risks and benefits to parents of children with multiple health conditions. Over 800 caregivers watched videos of a doctor visit and answered surveys. The goal was to see which information helped parents feel more ready to make a decisi…

This study compared two methods to increase COVID-19 testing among patients at Utah community health centers: text message reminders alone versus text messages plus a patient navigator who helped with logistics. Over 44,000 English- or Spanish-speaking adults with a working cell …

This completed study tested a smartphone app that gave parents and kids real-time tips on sun protection. 78 families with children aged 8-17 took part. The goal was to see if the app could help kids use more sunscreen and protective clothing and get fewer sunburns.

This study tested a virtual educational program called FLAPS, designed to help members of organizations learn how to support suicide prevention for autistic people. Fifty-one participants completed surveys before, after, and three months after the program, and some gave interview…

This study looked at how reducing daily steps by about 70% affects blood vessel function and muscle health in older adults. Researchers measured blood flow in arm and leg arteries to understand the role of oxidative stress. The goal is to learn why inactivity leads to muscle loss…

This study looked at how a natural hemp extract cosmetic product, containing CBD in coconut oil, enters the blood when applied to the skin or taken by mouth. Twenty healthy adults each tried both methods, with a 15-day break in between. Researchers measured CBD, THC, and their br…

This study explored whether adding mindfulness training to physical therapy is practical for people with long-term muscle and joint pain who also take opioid painkillers. Researchers developed a training manual for physical therapists and tested different ways to teach them mindf…

This small, completed study looked at how many Hydrus microstent surgeries glaucoma fellows need to perform before they become skilled. Researchers graded videos of surgeries from 5 fellows at three eye centers. The goal was to find the average number of cases needed to reach an …

This study tested a wireless insole device (Loadsol) in 58 people who had hip or knee replacement surgery. The goal was to see if the device could accurately measure how much weight they put on their leg while walking and if giving feedback could help improve their walking symmet…

This completed study followed 120 adults over 40 who had knee replacement surgery for osteoarthritis. Researchers compared four different knee implants to see how well patients moved, walked, climbed stairs, and felt about their recovery over two years. The goal was to identify w…

This study tested a training program for labor and delivery providers in Tanzania to reduce HIV stigma during childbirth. The training used simulations and hands-on learning to help providers offer more respectful care. Researchers compared how women rated their care before and a…

This study looked at which online messages about colon cancer screening are most convincing and likely to be shared. Over 2,200 Black and White Americans aged 45-74 rated different messages from websites. The goal was to find the best ways to encourage people to follow screening …

This study looked at over 3,000 people at risk for certain cancers to see if a patient-directed online genetic counseling approach works as well as standard care. Participants were randomly assigned to either use an automated genetics education assistant or receive enhanced stand…