Can a smart dosing tool prevent heart transplant rejection in children?
NCT ID NCT04380311
First seen Aug 03, 2026 · Last updated Aug 04, 2026 · Updated 1 time
Summary
This study tests a personalized dosing tool for tacrolimus, an immunosuppressant drug given to children after a heart transplant to prevent organ rejection. The tool uses a computer model that considers each child's age, kidney function, and other medications to calculate the best dose. The goal is to see if this approach helps children reach the target drug level faster and more consistently than standard dosing, which could improve long-term transplant outcomes.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Tacrolimus dosing support tool (a computer model that personalizes tacrolimus doses based on patient factors)
- What this could lead to
- If successful, this could lead to a more precise way to dose tacrolimus in children after heart transplant, potentially reducing rejection and improving long-term transplant survival.
- What could go wrong
- This is a small study (17 participants) and compares against historical data, so results may not be definitive. The tool's accuracy depends on the model's assumptions and may not work for all patients.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Primary Children's Hospital
Salt Lake City, Utah, 84112, United States
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University of Utah
Salt Lake City, Utah, 84112, United States
More trials for these conditions
Other studies related to the condition(s) this trial covers.
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