New blood test could replace painful heart biopsies for transplant patients

NCT ID NCT03575910

Completed Diagnosis Sponsor: University of British Columbia Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested a new blood test called HEARTBiT that uses 9 RNA markers to detect acute rejection in heart transplant patients. Currently, rejection is found through frequent, invasive heart biopsies. The test was developed using samples from 150 patients and will be evaluated in 400 new patients across 5 centers. If successful, it could offer a faster, cheaper, and safer way to monitor transplant health.

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Conditions

The condition(s) this trial relates to.

congestive heart failure heart disorder heart failure Rejection, Psychology transplant rejection

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HEART DISEASES HEART FAILURE HEART FAILURE, CONGESTIVE HEART TRANSPLANT FAILURE AND REJECTION TRANSPLANT FAILURE TRANSPLANT; FAILURE, HEART

Contacts and locations

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Locations

Ottawa Heart Institute

Ottawa, Ontario, K1Y4W7, Canada
St. Paul's Hospital

Vancouver, British Columbia, V6Z 1Y6, Canada
Toronto General Hospital UHN

Toronto, Ontario, M5G 2C4, Canada
University of Nebraska Medical Center

Omaha, Nebraska, 68198, United States