HEART DISEASES

This study tests a new heart pump called BrioVAD for people with severe heart failure that doesn't get better with standard treatments. The pump uses magnetic levitation to help the heart pump blood. About 780 adults will get either the BrioVAD or an existing pump to see if the n…

This study looks at how well two types of heart stents (Synergy XD and Synergy Megatron) work in real-life medical care. About 2000 adults with coronary artery disease will be followed to see if these stents reduce the risk of death, heart attack, or the need for another procedur…

This study tests whether a less extensive ablation approach, guided by advanced heart mapping, works as well as standard ablation for people with atrial tachycardia after prior heart surgery or atrial fibrillation treatment. About 100 adults will be randomly assigned to one of tw…

This study tests whether a mechanical heart pump (HeartMate 3) helps people with advanced heart failure live longer and avoid serious complications compared to standard medical therapy. About 850 participants who are not yet dependent on IV medications will receive either the pum…

This study tests a device called the Carillon Mitral Contour System in 300 people with heart failure and a leaky mitral valve. The device is placed in a vein to help the valve close better, reducing blood backflow. The goal is to see if it improves symptoms, walking ability, and …

This study tests whether using just one blood thinner (single antiplatelet therapy) is safer and as effective as two blood thinners (dual antiplatelet therapy) in older adults or those at high risk of bleeding who have had a heart procedure with a drug-coated balloon. About 576 p…

This study looks at two methods for closing the breastbone after open heart surgery in people at high risk for healing problems. Participants will be randomly assigned to receive either a metal plate and screws or traditional wires. The goal is to see which method leads to better…

This study compares two imaging methods to guide stent placement in people with calcified coronary artery disease. The goal is to see if using a CT scan to plan calcium removal leads to better stent expansion and similar safety compared to the usual ultrasound-guided procedure. A…

This study tests a new device (TS-RF system) that uses radiofrequency energy to help doctors safely reach the left side of the heart during procedures for abnormal heart rhythms or mitral stenosis. About 70 adults will be randomly assigned to receive either the new device or a st…

This study looks at whether using two or more artery grafts during heart bypass surgery is better than using just one. Researchers want to see if multiple grafts lower the risk of death, stroke, heart attack, or needing another procedure. About 4,300 adults with coronary artery d…

This study compares two types of heart bypass surgery in 2,300 women: using one artery (single arterial grafting) versus multiple arteries (multiple arterial grafting) to reroute blood around blocked heart vessels. The goal is to see which approach reduces the risk of heart attac…

This study tests if people with well-controlled recurrent pericarditis can safely switch from their current treatments to KPL-387 alone. About 80 adults will try different dosing plans to see which works best to prevent flare-ups. The goal is to find a simpler, effective long-ter…

This study is testing a new smartphone-connected 12-lead ECG device to see if it can accurately diagnose heart attacks (STEMI and NSTEMI) in people with chest pain. Researchers will compare the smartphone ECG readings to standard hospital ECGs in 1000 adults. The goal is to valid…

This study tests two methods of giving a contrast agent called Lumason during heart ultrasound. It compares giving the drug as a slow drip versus a single injection to see which provides clearer images of the heart's left ventricle. The study involves 106 adults whose initial ult…

This study tests an experimental drug called acoramidis in 587 adults who carry a gene that puts them at high risk for transthyretin amyloidosis (ATTR), a condition where sticky plaques damage the heart and nerves. The goal is to see if taking acoramidis early can prevent or dela…

This early study tests a small device placed in a heart vein to improve blood flow and reduce chest pain in people with coronary microvascular dysfunction. About 30 adults with persistent symptoms will receive the implant. The goal is to see if the device is safe and can relieve …

This study follows 2,500 adults aged 30-75 in Puerto Rico over two years to understand how stress, diet, and environment affect chronic diseases like heart disease, diabetes, and obesity. Researchers will collect health data and surveys to guide public health efforts. The study d…

This study involves 50 adults who need a pacemaker or defibrillator. Researchers are comparing two FDA-approved methods for placing a wire in a specific part of the heart called the Bachmann bundle. One method uses contrast dye and X-ray, while the other adds an ECG. The goal is …

This study aims to learn why American Indians are at high risk for chronic kidney disease and heart disease. Researchers will follow 500 participants over time, measuring kidney function and tracking heart problems. The goal is to identify key risk factors to improve prevention a…

This study looks at how well people from underrepresented groups (Black or non-White Hispanic) with heart or diabetes conditions can stick with a digital clinical trial done from home. Researchers will track how many participants follow the study plan and stay involved. The goal …

This study looks at how a short course of high-dose statins affects fatty buildup (plaque) in the heart arteries of people with mild heart disease. Researchers will use advanced CT scans to measure changes in plaque size and type over 3 months, and then check if those changes las…

This study follows 36 people aged 12 and older who have a genetic heart condition called PKP2-ACM. Researchers will monitor heart rhythms, biomarkers, and quality of life to learn how the disease progresses under standard care. No new treatments are tested—the goal is to gather i…

This study looks at whether giving routine heart ultrasound exams to nursing home residents can help catch heart problems early and reduce sudden heart failure episodes and unplanned hospital stays. About 1,050 residents will take part. Researchers will also check if this approac…

This study will give smartwatches to 10,000 adults with or without heart disease to collect health data over one year. Participants will also answer surveys through a phone app. The goal is to see if smartwatch data can help detect and understand heart problems earlier. No drugs …

This study looks for new genes and blood markers linked to arrhythmogenic cardiomyopathy, a genetic heart condition that can cause sudden cardiac arrest. Researchers will enroll 1,000 people with the condition or their family members from the US and UK. By collecting medical data…

This study is a registry that collects information on Abbott heart devices used in routine care. It will include up to 2500 people with conditions like holes in the heart or valve disease. The goal is to confirm the devices are safe and work well in everyday practice, not to test…

This study looks at how whole milk and skim milk affect blood sugar and cholesterol in 100 adults who drink at least one cup of dairy milk daily. Participants will switch between drinking only whole milk and only skim milk for set periods, while researchers track changes in their…

This study is testing a digital app called VIRTUES that helps people with heart conditions manage their health from home. The app provides personalized recommendations on topics like blood pressure, cholesterol, and lifestyle changes. Researchers will enroll 2000 participants to …

This study collects blood, tissue, and other biological samples from 10,000 volunteers, including healthy people and those with conditions like cancer, heart disease, and diabetes. The samples are stored in a biobank and shared with researchers to uncover how diseases develop and…

This study is monitoring the safety and performance of special tools (like delivery sets and pushers) used during heart implant procedures. About 685 people who receive these tools as part of their heart treatment will be included. Doctors will fill out surveys to report any prob…

This study tests whether a smartwatch connected to a digital platform can help doctors spot heart rhythm problems like atrial fibrillation early. About 520 adults with heart disease or who recently had a heart procedure will wear a smartwatch and a standard heart monitor. The goa…

This study collects DNA from 1200 patients receiving routine care at the University of Chicago. Researchers look for genetic differences that might affect how well a drug works or how likely it is to cause side effects. The goal is to see if giving this genetic information to doc…

This study looks at whether showing people a real-time ultrasound of their heart in the emergency room can motivate them to eat better, exercise more, and see their doctor. About 100 adults aged 45+ with high blood pressure, diabetes, or obesity will either get standard education…

This study is a registry that will collect information from 8,000 people having heart or chest surgery. The goal is to learn how different factors before and during surgery affect recovery, including risks like death, shock, or infection. No treatment is given—it is purely observ…

This study will follow 1,000 adults with psoriasis to understand how the skin condition is linked to heart disease. Researchers will use heart tests and blood markers to find early signs of heart problems. The goal is to improve heart health monitoring for people with psoriasis.

This study looks at 500 people who have had a stroke and also have atrial fibrillation (an irregular heartbeat). The goal is to understand why some people still have strokes even when taking blood thinners. Researchers will collect blood samples and heart ultrasound images to fin…