HEART DISEASES

This study tests a new device called the PULSTA valve, placed through a tube in a blood vessel to replace a faulty heart valve without open-heart surgery. It includes 58 people with leaky or narrowed pulmonary valves. The goal is to see if the valve works well and is safe over ti…

This study tests a device called the Supira System that temporarily helps the heart pump blood during high-risk procedures for blocked arteries. About 71 adults with coronary artery disease or heart failure will take part. The goal is to see if the device is safe and works well t…

This study tests whether using an insertable heart monitor to guide early treatment can reduce the amount of time people spend in atrial fibrillation (AFib) after a catheter ablation. About 120 adults with AFib will get the monitor before or during their ablation procedure. The g…

This study tests whether a new stent (SUPRAFLEX Cruz) works as well as an existing one (SYNERGY) in people with blockages in all three main heart arteries. About 1,550 patients will receive one of the stents during a procedure to open narrowed arteries. Researchers will track dea…

This study compares a new leadless pacemaker (Micra AV) to a standard dual-chamber pacemaker in 100 older adults with heart block. The goal is to see if the leadless version works as well for exercise capacity. Both devices control heart rhythm, but the leadless one avoids wires …

This study tested whether a risk score, calculated from electronic health records, could help find people with undiagnosed atrial fibrillation (AF). About 1,955 adults at higher or lower risk for AF wore a remote ECG monitor. The goal was to see if the higher-risk group had more …

This study tests whether a nerve block given before heart surgery can reduce pain and the need for strong painkillers like opioids afterward. About 150 adults having certain heart surgeries will be randomly assigned to receive one of two types of numbing medicine. The goal is to …

This study looks at whether older adults with a specific type of heart disease (cardiac amyloidosis) feel better when they stop taking a common heart medication called a beta-blocker. Twenty participants will each go through two periods—one on the drug and one off—to compare thei…

This study follows over 6,000 people over many years to see if feelings like hostility and other psychological factors are linked to heart disease. Researchers are tracking who develops heart problems and looking for patterns. The goal is to better understand how our minds and em…

This study tests whether the PulsePoint app can increase the number of people who receive CPR or a defibrillator from bystanders before paramedics arrive. About 340 adults who suffer sudden cardiac arrest in public places will be included. Half of the 911 calls will trigger the a…

This study follows over 2,300 South Asian adults (ages 40-84) in the U.S. to uncover why they have high rates of heart disease and stroke, even without traditional risk factors. Researchers measure artery calcium and other markers over several years. The goal is to identify new r…

This study explores whether changing how people connect online can help improve COVID-19 vaccine attitudes and intentions, especially for African American and Latinx communities who often face health inequities. About 4,500 adults in the US with internet access are taking part. R…

This study follows over 5,000 Black and White men and women from age 18-30 for many years to see how their lifestyles and health habits affect their risk of heart disease later in life. Researchers measure things like blood pressure, weight, and cholesterol to understand why some…

This study examines whether a common gene variation (CYP2C19) influences the long-term risk of serious heart and blood vessel events, such as heart attacks, strokes, and limb problems, in people with vascular disease. Researchers will analyze genetic and health data from 13,000 p…

This study was designed to see if a cholesterol-lowering drug called a PCSK9 inhibitor could also reduce inflammation in the arteries of people with heart disease. Researchers planned to use a special imaging scan to measure inflammation. The study was withdrawn before enrolling …

This study watches how over 800 heart failure patients in Germany take dapagliflozin as part of their normal care. Researchers track how long patients stay on the drug, any side effects, and changes in symptoms and quality of life. The goal is to understand how well the medicine …

This study followed over 6,800 adults from different racial and ethnic backgrounds to understand how heart disease develops over time. Participants were healthy at the start and were monitored for risk factors and heart-related events like heart attacks and strokes. The goal is t…

This study tests whether a civic engagement program can help rural adults improve their heart health by eating better and being more active. About 2,420 adults from rural New York towns will work together to identify barriers and create community projects. The goal is to see if t…

This study looks at bacteria that enter the bloodstream during dental treatment for gum disease. Researchers want to find biological markers that can quickly tell if someone has a bloodstream infection, which could help diagnose sepsis faster. About 100 adults with gum disease ar…

This study tests whether a personalized approach called N-of-1 trials can help older adults (65+) with a type of heart failure (HFpEF) feel more confident about continuing or stopping their beta-blocker medication. Twenty participants will go through a tailored trial to see how t…

This study tests whether a phone app called StudyU can help people with heart failure reach their recommended beta blocker dose. Five adults aged 65 and older with heart failure will use the app to track their medication. The goal is to see if the app is practical and acceptable …

This study follows over 5,000 people with stable heart disease for up to 10 years to compare two treatment approaches: an early invasive strategy (like stents or bypass surgery) plus medications, versus medications alone. Researchers want to see which strategy leads to fewer deat…

This study followed nearly 6,000 adults aged 65 and older to learn what factors predict heart disease, stroke, and related health problems. Researchers aimed to identify risks and understand what leads to disability or death after a heart event. The study did not test a new treat…

This study looks at whether giving doctors a special risk score—which combines a person's genes with things like cholesterol and age—helps them make better decisions to prevent heart disease. About 1,000 people at medium risk for heart problems will be randomly assigned to have t…