HEART DISEASES

This study tested whether taking two blood pressure medicines together (valsartan and hydrochlorothiazide) works better than taking just one (valsartan) for people with hypertensive heart disease. 118 adults aged 18-70 took part for 8 weeks. The goal was to see which approach con…

This study tested a new drug called tovinontrine in 303 adults with chronic heart failure where the heart pumps normally but is stiff. The goal was to see if the drug lowers a key heart stress marker (NT-proBNP) more than a placebo over 12 weeks. Participants were randomly assign…

This study tested whether giving metoprolol, an FDA-approved heart medication, right after surgery and during hospital recovery can reduce heart damage in people with coronary artery disease. The trial involved 72 adults aged 50 and older who were not already taking beta-blockers…

This study tested a very small balloon catheter (Sapphire 3) in 170 people with completely blocked heart arteries (chronic total occlusion). The balloon was used to open the blockage before placing a stent. The main goal was to see if the balloon could be safely delivered, inflat…

This study looked at how safe and effective the SAPIEN XT heart valve is for people whose right ventricle valve is not working properly. The valve was placed using a thin tube through a blood vessel, avoiding open-heart surgery. The study included 57 people and checked if they we…

This study tested a new drug called tovinontrine in 557 adults with chronic heart failure and a weakened heart pump. The goal was to see if the drug could lower a key marker of heart strain (NT-proBNP) compared to a placebo over 12 weeks. Participants were randomly assigned to re…

This study looked at whether taking two blood thinners (clopidogrel and aspirin) for a longer time can prevent major heart problems like heart attacks, strokes, or death in people with multiple blocked heart arteries. Over 8,000 adults who had a stent placed were randomly assigne…

This study tested a culturally-tailored program that combines stress management, healthy eating, and exercise for African American women at risk for heart disease, stroke, and diabetes. 175 women participated to see if the program could help them be more active and eat healthier.…

This study tested a new blood test called HEARTBiT that uses 9 RNA markers to detect acute rejection in heart transplant patients. Currently, rejection is found through frequent, invasive heart biopsies. The test was developed using samples from 150 patients and will be evaluated…

This study tested a new automatic tool in a small, portable ultrasound device that measures how well the heart pumps blood. Researchers wanted to see if this tool gives more consistent results than the usual visual assessment by doctors. The study involved 60 adults with breathin…

This study tested a device called preCARDIA that temporarily blocks a large vein in the chest to help patients with sudden, severe heart failure. The goal was to see if it is safe and can help remove excess fluid when standard treatments are not working. The study included 60 adu…

This study looked at whether giving people with heart failure free, medically tailored meals for 12 weeks could improve their diet quality. 60 adults with heart failure took part. The main goal was to see if their eating habits got healthier by the end of the 12 weeks.

This study looked at whether viral infections and diabetes in pregnant women increase the risk of congenital heart defects in babies. Researchers analyzed blood and stool samples from 114 women to detect viruses and immune responses. The goal was to gather knowledge for future la…

This study looked at how a high-fat, high-sugar Western diet changes immune cells called monocytes in healthy, normal-weight adults aged 20-45. Eight participants ate a controlled Western diet for 8 weeks. Researchers measured specific proteins and genes in the blood to understan…

This study compared the effects of full-fat and fat-free milk and yogurt on gut bacteria and heart disease risk. 37 adults over 50 with overweight participated. Researchers measured changes in gut microbes, waste products, and blood markers to see if dairy fat content or fermenta…

This study used portable heart monitors to track heart rhythm problems in 268 adults with kidney failure on dialysis. The goal was to see how common these rhythm issues are and whether they are linked to serious heart events like sudden cardiac death or heart attack within one ye…

This study investigated whether eating soy foods reduces the risk of heart attacks and fatal heart disease in Chinese women. Researchers followed over 135,000 women aged 40 to 70 living in study communities. The goal was to see if soy intake is linked to better heart health.

This study aimed to find out if silent myocardial ischemia (a lack of blood flow to the heart without symptoms) increases the risk of heart-related death or problems in people with coronary heart disease. Researchers followed participants for one to three years to observe outcome…

This study aimed to find out if certain genes make people more likely to die suddenly from a heart problem. Researchers looked at the DNA of 2,500 people to see if specific gene variations were linked to sudden cardiac death. No treatments or interventions were given; the goal wa…

This study looked at whether a heart ultrasound (TEE) should be used routinely or only when needed during low-risk coronary bypass surgery. Researchers enrolled 40 adults with good heart function to test if such a study is feasible. The goal is to help doctors decide when TEE is …