New heart failure pill shows promise in Mid-Stage trial

NCT ID NCT06215911

Completed Disease control Sponsor: Cardurion Pharmaceuticals, Inc. Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This Phase 2 trial tested the drug tovinontrine (CRD-750) against a placebo in 557 adults with chronic heart failure and reduced pumping ability. The goal was to see if the drug safely lowers a key heart stress marker called NT-proBNP over 12 weeks. The study is complete, and results will show whether tovinontrine may help control this serious condition.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: tovinontrine (CRD-750)
What this could lead to: If it works, this could lead to a new oral medication to help control chronic heart failure and improve heart function.
What could go wrong: This is a Phase 2 trial, so it's still early. The drug may not lower NT-proBNP enough or could have side effects. Results may not apply to all heart failure patients.

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Conditions

The condition(s) this trial relates to.

cardiovascular disorder heart disorder heart failure systolic heart failure

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CARDIOVASCULAR DISEASES HEART DISEASES HEART FAILURE HEART FAILURE WITH REDUCED EJECTION FRACTION

Contacts and locations

Locations

Cardurion Investigational Site

Bruges, 8000, Belgium
Cardurion Investigative Site

Birmingham, Alabama, 35233, United States
Cardurion Investigative Site

Little Rock, Arkansas, 72204, United States
Cardurion Investigative Site

Beverly Hills, California, 90211, United States
Cardurion Investigative Site

Orange, California, 92868, United States
Cardurion Investigative Site

Torrance, California, 90502, United States
Cardurion Investigative Site

Van Nuys, California, 91405, United States
Cardurion Investigative Site

Jacksonville, Florida, 32216, United States
Cardurion Investigative Site

Miami, Florida, 33137, United States
Cardurion Investigative Site

Hazel Crest, Illinois, 60429, United States
Cardurion Investigative Site

Peoria, Illinois, 61636, United States
Cardurion Investigative Site

Alexandria, Louisiana, 71301, United States
Cardurion Investigative Site

Covington, Louisiana, 70433, United States
Cardurion Investigative Site

Baltimore, Maryland, 21201, United States
Cardurion Investigative Site

St Louis, Missouri, 63110, United States
Cardurion Investigative Site

Omaha, Nebraska, 68198, United States
Cardurion Investigative Site

Buffalo, New York, 14215, United States
Cardurion Investigative Site

New York, New York, 10025, United States
Cardurion Investigative Site

Cleveland, Ohio, 44195, United States
Cardurion Investigative Site

Oklahoma City, Oklahoma, 73135, United States
Cardurion Investigative Site

Rapid City, South Dakota, 57701, United States
Cardurion Investigative Site

Nashville, Tennessee, 37232, United States
Cardurion Investigative Site

Dallas, Texas, 75226, United States
Cardurion Investigative Site

McKinney, Texas, 75069, United States
Cardurion Investigative Site

Burlington, Vermont, 05401, United States
Cardurion Investigative Site

Seattle, Washington, 98195, United States
Cardurion Investigative Site

Madison, Wisconsin, 53792, United States
Cardurion Investigative Site

Southport, Queensland, 4222, Australia
Cardurion Investigative Site

Chermside, 4032, Australia
Cardurion Investigative Site

Perth, Australia
Cardurion Investigative Site

Brussels, 1070, Belgium
Cardurion Investigative Site

Brussels, Belgium
Cardurion Investigative Site

Genk, Belgium
Cardurion Investigative Site

Ghent, 9000, Belgium
Cardurion Investigative Site

Hasselt, 3500, Belgium
Cardurion Investigative Site

Kortrijk, 8500, Belgium
Cardurion Investigative Site

Sint-Niklaas, 9100, Belgium
Cardurion Investigative Site

Burgas, 8008, Bulgaria
Cardurion Investigative Site

Gabrovo, 5300, Bulgaria
Cardurion Investigative Site

Pazardzhik, 4400, Bulgaria
Cardurion Investigative Site

Plovdiv, 4002, Bulgaria
Cardurion Investigative Site

Plovdiv, 4003, Bulgaria
Cardurion Investigative Site

Rousse, 7000, Bulgaria
Cardurion Investigative Site

Sofia, 1000, Bulgaria
Cardurion Investigative Site

Sofia, 1233, Bulgaria
Cardurion Investigative Site

Stara Zagora, 6000, Bulgaria
Cardurion Investigative Site

Veliko Tarnovo, 5006, Bulgaria
Cardurion Investigative Site

Cambridge, Ontario, N1R 6V6, Canada
Cardurion Investigative Site

Hamilton, Ontario, L8L 2X2, Canada
Cardurion Investigative Site

Chicoutimi, Quebec, G7H 7K9, Canada
Cardurion Investigative Site

Montreal, Quebec, Canada
Cardurion Investigative Site

Sherbrooke, J1G 2E8, Canada
Cardurion Investigative Site

Trois-Rivières, G9B 2N3, Canada
Cardurion Investigative Site

Hradec Králové, 500 02, Czechia
Cardurion Investigative Site

Hradec Králové, 500 05, Czechia
Cardurion Investigative Site

Prague, 128 08, Czechia
Cardurion Investigative Site

Tbilisi, 0102, Georgia
Cardurion Investigative Site

Tbilisi, 0131, Georgia
Cardurion Investigative Site

Tbilisi, 0141, Georgia
Cardurion Investigative Site

Tbilisi, 0159, Georgia
Cardurion Investigative Site

Tbilisi, 0160, Georgia
Cardurion Investigative Site

Tbilisi, 0186, Georgia
Cardurion Investigative Site

Berlin, Brandenburg, 10787, Germany
Cardurion Investigative Site

Elsterwerda, Brandenburg, 04910, Germany
Cardurion Investigative Site

Papenburg, Lower Saxony, 26871, Germany
Cardurion Investigative Site

Dresden, 01067, Germany
Cardurion Investigative Site

Magdeburg, 39120, Germany
Cardurion Investigative Site

Balatonfüred, 8230, Hungary
Cardurion Investigative Site

Budapest, 1148, Hungary
Cardurion Investigative Site

Budapest, H-1122, Hungary
Cardurion Investigative Site

Gyöngyös, 3200, Hungary
Cardurion Investigative Site

Hatvan, 3000, Hungary
Cardurion Investigative Site

Kaposvár, 7400, Hungary
Cardurion Investigative Site

Orosháza, 5900, Hungary
Cardurion Investigative Site

Zalaegerszeg, 8900, Hungary
Cardurion Investigative Site

Bergamo, Italy
Cardurion Investigative Site

Milan, 20138, Italy
Cardurion Investigative Site

Naples, Italy
Cardurion Investigative Site

Rozzano, Italy
Cardurion Investigative Site

Riga, Latvia
Cardurion Investigative Site

Kaunas, Lithuania
Cardurion Investigative Site

Klaipėda, Lithuania
Cardurion Investigative Site

Panevezys, Lithuania
Cardurion Investigative Site

Goes, 4462 RA, Netherlands
Cardurion Investigative Site

Groningen, 9713 GZ, Netherlands
Cardurion Investigative Site

Hardenberg, 7772 SE, Netherlands
Cardurion Investigative Site

Sneek, 8601 ZR, Netherlands
Cardurion Investigative Site

The Hague, 2545 AA, Netherlands
Cardurion Investigative Site

Utrecht, 3582 KE, Netherlands
Cardurion Investigative Site

Veldhoven, 5504 DB, Netherlands
Cardurion Investigative Site

Zutphen, 7207 AE, Netherlands
Cardurion Investigative Site

Christchurch, New Zealand
Cardurion Investigative Site

Dunedin, New Zealand
Cardurion Investigative Site

Grodzisk Mazowiecki, 05-825, Poland
Cardurion Investigative Site

Krakow, 31-216, Poland
Cardurion Investigative Site

Lodz, 92-213, Poland
Cardurion Investigative Site

Lodz, 94-255, Poland
Cardurion Investigative Site

Lodz, Poland
Cardurion Investigative Site

Lublin, 20-011, Poland
Cardurion Investigative Site

Lublin, 20-049, Poland
Cardurion Investigative Site

Sopot, 81-717, Poland
Cardurion Investigative Site

Szczecin, Poland
Cardurion Investigative Site

Torun, 87-100, Poland
Cardurion Investigative Site

Warsaw, 04-628, Poland
Cardurion Investigative Site

Wroclaw, 50-556, Poland
Cardurion Investigative Site

Wroclaw, 50-981, Poland
Cardurion Investigative Site

Bardejov, Slovakia
Cardurion Investigative Site

Bratislava, Slovakia
Cardurion Investigative Site

Handlová, 972 51, Slovakia
Cardurion Investigative Site

Košice, 040 022, Slovakia
Cardurion Investigative Site

Košice, Slovakia
Cardurion Investigative Site

Nitra, 949 01, Slovakia
Cardurion Investigative Site

Prešov, 080 01, Slovakia
Cardurion Investigative Site

Žilina, Slovakia
Cardurion Investigative Site

El Palmar, Murcia, 30120, Spain
Cardurion Investigative Site

Alicante, 03010, Spain
Cardurion Investigative Site

Córdoba, 14004, Spain
Cardurion Investigative Site

Madrid, 28041, Spain
Cardurion Investigative Site

Málaga, 29010, Spain
Cardurion Investigative Site

Santiago de Compostela, 15706, Spain
Cardurion Investigative Site

Seville, 41009, Spain
Cardurion Investigative Site

Valencia, 46026, Spain
Cardurion Investigative Site

Kaohsiung City, 80756, Taiwan
Cardurion Investigative Site

New Taipei City, 243, Taiwan
Cardurion Investigative Site

Taichung, 407219, Taiwan
Cardurion Investigative Site

Taipei, 100225, Taiwan
Cardurion Investigative Site

Taipei, 10507, Taiwan
Cardurion Investigative Site

Wythenshawe, Manchester, M23 9QZ, United Kingdom
Cardurion Investigative Site

Bridgend, CF31 1RQ, United Kingdom
Cardurion Investigative Site

Chichester, PO19 6SE, United Kingdom
Cardurion Investigative Site

Dundee, DD1 9SY, United Kingdom
Cardurion Investigative Site

Glasgow, G81 4DY, United Kingdom
Cardurion Investigative Site

Harrow, HA1 3UJ, United Kingdom
Cardurion Investigative Site

Isleworth, TW7 6AF, United Kingdom
Cardurion Investigative Site

London, NW1 2BU, United Kingdom
Cardurion Investigative Site

London, SE5 9RS, United Kingdom
Cardurion Investigative Site

Southampton, SO16 6YD, United Kingdom
Cardurion Investigative Site 2

Sofia, 1233, Bulgaria
Cardurion Investigative Site 2

Tbilisi, 0159, Georgia

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