HEART DISEASES

This study compares two imaging methods to guide stent placement in people with calcium buildup in their heart arteries. About 700 adults with signs of reduced blood flow to the heart will be randomly assigned to have their procedure guided by either a coronary CT angiogram or th…

This study compares two methods of closing the breastbone after open heart surgery: rigid plates versus traditional wires. It includes 250 adults at high risk for wound problems, such as those with diabetes or obesity. The goal is to see which method leads to better bone healing …

This study tests how well people with well-controlled recurrent pericarditis (a condition where the heart's lining swells repeatedly) can switch from their current treatments to a new drug called KPL-387 taken alone. About 80 adults will be enrolled to find the best dosing plan a…

This study tests a new heart pump called BrioVAD for people with severe heart failure that doesn't get better with other treatments. The pump uses magnetic levitation to help the heart pump blood. About 780 adults will take part to see if this device is as safe and effective as a…

This study tests whether a mechanical heart pump (HeartMate 3) can help people with advanced heart failure live longer and avoid serious complications like stroke or the need for a heart transplant. About 850 participants will either receive the pump or continue standard medical …

This study looks at how well two types of heart stents (Synergy XD and Synergy Megatron) work in everyday medical practice. About 2000 adults with coronary artery disease will receive these stents to open blocked arteries. Researchers will track deaths, heart attacks, and the nee…

This study looks at whether using just one blood thinner (single antiplatelet therapy) is safer and as effective as using two (dual antiplatelet therapy) in older adults or those at high risk of bleeding who have had a heart procedure with a drug-coated balloon. About 576 partici…

This study tests a device called the Carillon Mitral Contour System in 300 people with heart failure and a leaky mitral valve. The device is placed in a vein near the heart to help the valve close better. The goal is to see if it improves symptoms, walking ability, and reduces ho…

This study aims to find out if using multiple arteries for heart bypass surgery is better than using just one artery in women with coronary artery disease. About 2,300 women will be randomly assigned to one of the two surgical approaches. Researchers will track heart-related even…

This study tests two methods of giving the contrast agent Lumason during a heart ultrasound. About 106 adults whose heart walls are hard to see on a standard ultrasound will receive the dye both as a single shot and as a slow drip. The goal is to see which method provides clearer…

This study tests a new smartphone-based 12-lead ECG device to see if it can accurately detect heart attacks (STEMI and NSTEMI) compared to standard hospital ECGs. About 1,000 adults with chest pain will be enrolled in emergency departments. The goal is to validate the device as a…

This study tests an experimental drug called acoramidis in 587 adults who carry a gene mutation for transthyretin amyloidosis (ATTR) but have no symptoms yet. The drug aims to stabilize a protein in the blood to prevent it from forming harmful plaques in the heart and nerves. If …

This early study tests a device called the A-FLUX Reducer, placed in a heart vein, to improve chest pain in 30 adults with microvascular angina (small vessel heart disease). The goal is to see if it is safe and can reduce symptoms. Participants must have had persistent chest pain…

This study collects DNA samples from 1200 adults receiving routine care at the University of Chicago. Researchers test for genetic differences that could affect how patients respond to certain medications, including risk of side effects. The results are shared with their doctors,…

This study follows 36 people with a rare genetic heart condition called PKP2-ACM to track how the disease progresses over time. Participants receive standard care while researchers monitor heart rhythms, biomarkers, and quality of life. The goal is to better understand the condit…

This study tests whether a smartwatch and a digital platform can help doctors detect heart rhythm problems like atrial fibrillation early in people with heart disease. About 520 adults will wear a smartwatch and sometimes a portable heart monitor for up to 45 days. The goal is to…

This study is a large registry that will collect information from 8,000 people having heart or lung surgery. The goal is to find out which factors before and during surgery are linked to serious problems afterward, such as death, shock, or needing another operation. The results m…

This study will give 10,000 adults with or without heart disease a smartwatch to wear for one year. The watch collects health data, and participants answer questions through a phone app. Researchers will use this information to see if smartwatches can help detect and understand h…

This study tests whether showing people a real-time ultrasound of their heart in the emergency room, along with standard education, helps them understand their heart failure risk and motivates them to improve diet, exercise, and see a doctor. About 100 adults aged 45+ with high b…

This study looks at how whole milk versus skim milk affects blood sugar and cholesterol in adults. Researchers will ask 100 people who drink at least one cup of milk daily to switch between whole and skim milk for a set time. The goal is to see which type of milk is better for he…

This study looks at whether people from underrepresented groups (Black or non-White Hispanic) with heart disease or related conditions can successfully take part in a clinical trial from home using digital tools. Researchers will track how many participants stick with the program…

This study is for adults with psoriasis who want to help researchers understand the link between psoriasis and heart disease. The goal is to see if certain heart tests and blood markers can predict future heart problems. Participants will be followed over time to track heart heal…

This study enrolls 500 people who have had a stroke and also have atrial fibrillation (an irregular heartbeat). Researchers want to understand why some strokes happen even when patients take blood thinners. They will collect blood samples and heart ultrasound images, then follow …

This study looks at how a short course of high-dose statins affects fatty buildup (plaque) in the heart's arteries. About 140 adults with mild heart disease will get either a statin or a placebo, and advanced CT scans will track changes over 3 months. The goal is to understand wh…

This study follows 685 people who receive heart implants using special Occlutech tools. Doctors will fill out surveys to track how well the tools work and if any problems happen during or after the procedure. The goal is to make sure these tools are safe and easy to use.

This study is a large registry that will follow 2500 people who receive Abbott heart devices (like those for hole-in-heart repairs or valve disease) during routine care. The goal is to confirm the devices are safe and work well in everyday hospital practice. Participants just rec…

This study involves 50 people who need a pacemaker or defibrillator. Researchers want to see if using contrast dye and X-ray alone is better than adding an electrocardiogram (ECG) for placing a wire in a specific part of the heart called the Bachmann bundle. Both methods are alre…

This study looks at whether giving routine heart ultrasounds to nursing home residents can help catch heart problems early and reduce emergency hospital visits. About 1,050 residents will take part. The goal is to see if this screening is practical and effective in a nursing home…

This study is testing a digital app called VIRTUES to help people with heart conditions manage their health at home. The app provides personalized recommendations on medications, diet, exercise, and more. Researchers will enroll 2000 participants to use the app for one month and …

This study is building a large collection of human biological samples and health data to help scientists understand diseases better. It will collect samples from up to 10,000 people, including both healthy individuals and those with conditions like cancer, heart disease, and diab…