HEART DISEASES

This study follows 5,391 people with stable heart disease for up to 10 years to see which initial treatment approach helps people live longer. Participants were originally assigned to either receive heart procedures plus medications or medications alone. Researchers are now track…

This study is testing a new device called the PULSTA valve for people with a leaky or narrowed pulmonary heart valve. The device is implanted using a catheter through blood vessels, avoiding open-heart surgery. Researchers will check if it's safe and improves heart function over …

This study is testing if using a small, implanted heart monitor helps doctors better manage irregular heartbeats (atrial fibrillation or AFib) after a common procedure called catheter ablation. The monitor sends data to doctors, allowing for quicker treatment adjustments. The goa…

This study is testing a new temporary heart pump device called the Supira System. It's designed to help support patients' blood pressure and heart function during complex, high-risk procedures to open blocked heart arteries. The research aims to see if the device is safe and work…

This study is comparing two different types of biodegradable heart stents (SUPRAFLEX Cruz vs. SYNERGY) in patients with severe blockages in all three major heart arteries. About 1,550 participants will have the stents placed and be followed for at least a year to see which stent …

This study is testing a new method to find people at high risk for atrial fibrillation (AF), a common heart rhythm problem that can lead to stroke. It uses a computer-based risk score from health records to identify nearly 2,000 participants, who then receive remote heart monitor…

This study tests whether changing how people connect in online social networks can improve attitudes toward COVID-19 vaccination and reduce health misinformation. Researchers are recruiting thousands of U.S. adults, focusing on African American communities, to see if less central…

This study tests whether training and supporting small groups of residents to improve their local environment—like adding walking trails or healthier food options—can help prevent heart disease. Over 2,400 adults in rural Texas and New York communities will participate, either by…

This study is checking if older adults with a rare heart condition called cardiac amyloidosis feel better and can exercise more when they stop taking their beta-blocker medicine. Twenty participants will try two periods: one on their usual dose and one with the medicine slowly re…

This study investigates whether a standard dental cleaning for gum disease can be used as a model to find better markers in the blood for detecting sepsis, a life-threatening infection. Researchers are studying 100 people with gum disease to see if bacteria released into the bloo…

This study is testing whether a new genetic risk score helps doctors and patients manage heart disease risk better. It will follow 1,000 adults without known heart disease for 5 years to see if getting this score changes how doctors prescribe medications or order tests, and if it…

This long-term study followed nearly 5,900 adults aged 65 and older to identify what factors predict heart disease and stroke in the elderly. Researchers tracked participants' health over decades, using exams and tests to understand how risk factors like high blood pressure and c…

This is a long-term observational study that aims to understand how heart and blood vessel diseases develop in people before they show symptoms. It follows over 6,400 healthy men and women from four different ethnic backgrounds, aged 45-84, using regular scans and tests over many…

This study is testing a personalized approach to help older adults with a common type of heart failure decide whether to continue taking their beta-blocker medication. Researchers will work with 20 participants, having each person try periods on and off their prescribed beta-bloc…

This is a long-term observational study that began in 1985 to understand how heart disease risk factors develop in young adulthood. It follows over 5,000 Black and White men and women who were 18-30 years old when they joined. The goal is to identify which lifestyle habits and ch…

This study aims to find out why people of South Asian descent have higher rates of heart disease and stroke, even when typical risk factors are accounted for. Researchers are following over 2,300 South Asian adults in the US for several years to identify new causes. The goal is t…

This study aims to understand how the drug dapagliflozin is used for heart failure in real-world medical settings in Germany. It will observe 765 patients who have recently started taking the drug to see how long they stay on it, if their symptoms and quality of life improve, and…

This study is observing thousands of University of North Carolina alumni over many years to learn if personality traits like hostility and depression are connected to the development of heart disease. It is not testing a treatment; instead, it aims to gather knowledge by tracking…

This study is testing whether a smartphone app called StudyU can help older adults with a specific type of heart failure (HFrEF) safely reach their recommended beta blocker dose. It's a small pilot study with just 5 participants, focusing on whether using the app for personalized…

This study aimed to understand how powerful cholesterol-lowering drugs (PCSK9 inhibitors) affect inflammation in the arteries of people with heart disease. Researchers planned to use a special imaging scan to measure inflammation in participants already on standard statin medicat…

The goal of this pilot study is to describe and compare Ultrasound-Guided Erector Spinae Plane (ESP) Blocks using Exparel® (bupivacaine liposome injectable suspension) to Marcaine® (bupivacaine hydrochloride) for pain management and outcomes after cardiac surgeries.