HEART DISEASES

This study tests a temporary heart pump (Supira System) in 71 people with heart disease who need a high-risk procedure to open blocked arteries. The pump is designed to keep blood pressure stable during the procedure. The goal is to see if the device is safe and works as intended…

This study tests whether using an insertable heart monitor to guide early treatment can reduce the amount of time people spend in atrial fibrillation (AFib) after a catheter ablation. About 120 adults with AFib will get a small monitor placed under their skin before or during the…

This study compares a new leadless pacemaker (Micra AV) to a traditional pacemaker with wires in 100 patients aged 70 and older who need a pacemaker for heart block. The goal is to see if the leadless device works as well for exercise capacity. Both devices help control heart rhy…

This study tests two different drug-coated stents (SUPRAFLEX Cruz and SYNERGY) in about 1,550 people with severe blockages in all three main heart arteries. Participants receive state-of-the-art care including imaging and medication. The goal is to see which stent better prevents…

This study tests a new device called the PULSTA valve, which is placed inside the heart through a tube in a blood vessel, avoiding open-heart surgery. It is for 58 people with leaky or narrowed pulmonary valves, often due to a birth defect. The goal is to see if the valve works w…

This study tested whether a risk score based on health records can help find people with hidden atrial fibrillation (AF), a common heart rhythm problem that raises stroke risk. About 1,955 adults aged 30 and older with certain risk factors used a remote ECG monitor at home. The g…

This study looks at whether older adults (65+) with a specific type of heart disease (TTR cardiac amyloidosis) feel better when they stop taking beta-blockers, a common heart medication. Twenty participants will go through two periods—one on the drug and one off—to compare exerci…

This study tests whether a nerve block given before heart surgery can reduce pain and the need for strong painkillers afterward. About 150 adults having certain heart surgeries will get either a long-lasting or standard numbing medicine. The goal is to see which works better for …

This study tests whether giving doctors a special risk score—one that combines a person's genes with things like cholesterol and age—helps them make better decisions to prevent heart disease. About 1,000 people at moderate risk for heart disease but who have never had a heart att…

This study follows over 6,000 people over many years to see if traits like hostility and other emotional factors are linked to heart disease. Researchers are observing participants without giving any treatment. The goal is to better understand what leads to heart problems, not to…

This study looks at whether changing how people connect online can help improve COVID-19 vaccine attitudes and intentions, especially for African American and Latinx communities who often face health inequities. About 4,500 adults in the US with internet access are taking part. R…

This study looks at bacteria that enter the bloodstream during dental treatment for gum disease. Researchers want to find biological markers that could help detect sepsis earlier, which could save lives. About 100 adults with gum disease are taking part, and the goal is to improv…

This study tracks over 800 heart failure patients in Germany who are starting dapagliflozin, a recently approved drug. Researchers will observe how long patients stay on the medication, any side effects, and changes in symptoms and quality of life. The goal is to understand how t…

This study involves about 2,400 rural adults in New York and Texas. Participants will join a civic engagement program where they identify local barriers to healthy eating and physical activity, then create community projects to address them. The goal is to see if this approach im…

This study followed nearly 6,000 adults aged 65 and older to learn what factors predict heart disease, stroke, and related disabilities. Researchers measured known risks like high blood pressure and diabetes to see how they affect older people's health over time. The goal was to …

This study follows 2,314 South Asian adults (ages 40-84) in the US to uncover why they have high rates of heart disease and stroke, even without typical risk factors. Researchers measure artery calcium, diabetes, and other markers over time. The goal is to identify unique causes …

This study follows over 5,000 people with stable heart disease for up to 10 years to compare two treatment approaches: an early invasive strategy (procedures like stents or bypass surgery plus medications) versus medications alone. The goal is to see which strategy leads to fewer…

This study tests a personalized approach called N-of-1 trials to help older adults with a type of heart failure (HFpEF) decide whether to continue or stop taking beta-blockers. About 20 participants will try different medication schedules and report their confidence and preferenc…

This study tests whether a phone app called StudyU can help people with heart failure reach the recommended dose of their beta blocker medicine. Five adults aged 65 and older with heart failure will use the app. The goal is to see if the app is practical and acceptable for patien…

This study follows over 5,000 Black and White adults from age 18-30 for decades to see how their lifestyles and risk factors affect heart disease later in life. Researchers measure things like blood pressure, cholesterol, and weight to understand what leads to heart attacks, stro…

This study examines whether a common gene variation (CYP2C19) affects the long-term risk of serious heart and blood vessel problems, such as heart attacks, strokes, and limb complications. Researchers will analyze medical records from 13,000 adults who have already had genetic te…

This study was designed to see if a cholesterol-lowering drug called a PCSK9 inhibitor could also reduce inflammation in the arteries of people with heart disease. Researchers planned to use a special imaging scan to measure inflammation. However, the study was withdrawn before e…

This study looks at whether a mobile app called PulsePoint can increase the number of people who receive CPR or a defibrillator from bystanders before emergency services arrive. About 340 adults who suffer a cardiac arrest in a public place will be included. Half of the emergency…

This long-term study aims to understand how early, hidden signs of heart disease develop and predict future heart attacks, strokes, and heart failure. It follows over 6,400 adults from four different ethnic groups who started the study with no known heart disease. Researchers use…