HEART DISEASES

This study tested a new drug called tovinontrine in 303 adults with chronic heart failure (a condition where the heart doesn't pump as well as it should). The goal was to see if the drug could lower a key marker of heart strain (NT-proBNP) compared to a placebo. The trial has com…

This study tested a new medicine called tovinontrine in 557 adults with chronic heart failure and reduced pumping ability. The goal was to see if it safely lowers a key heart stress marker (NT-proBNP) compared to a placebo. Participants took the drug or placebo for 12 weeks, and …

This study tested the SAPIEN XT heart valve in 57 people whose right heart valve was leaky or narrowed. The goal was to see if the valve was safe and worked well. Most participants had a history of congenital heart disease.

This study tested whether giving metoprolol, an FDA-approved heart medication, right after surgery and during hospital recovery can reduce heart damage in people with coronary artery disease. Researchers monitored daily blood tests for signs of heart injury in 72 older adults. Th…

This study tested a culturally-tailored program that combines stress management, healthy eating, and exercise for African American women. 175 women with risk factors like high blood pressure or prediabetes took part. The goal was to see if the program could help them be more acti…

This study tested whether taking two blood pressure medicines together (valsartan and hydrochlorothiazide) works better than taking just one (valsartan alone) in people with high blood pressure that has already affected their heart. A total of 118 adults aged 18 to 70 took part. …

This study tested a tiny balloon catheter designed to open completely blocked heart arteries (chronic total occlusions) before placing a stent. 170 adults with coronary artery disease took part. The main goal was to see if the balloon could be safely delivered, inflated, and remo…

This large study tested whether taking two blood-thinning medications (clopidogrel plus aspirin) is more effective than taking just aspirin alone for patients with multiple blocked heart arteries who received a stent. The goal was to see if the two-drug combination better prevent…

This study tested a new automatic tool in a small, portable ultrasound device to measure how well the heart pumps blood (ejection fraction). The goal was to see if this tool gives more consistent results than the usual visual method used in emergency rooms. About 60 adults with s…

This study tested a device called preCARDIA that temporarily blocks a large vein in the chest to help people with severe heart failure who are not getting better with standard treatments. The study included 60 adults with advanced heart failure. The goal was to see if the device …

This study gave 60 people with heart failure free, medically tailored meals for 12 weeks to see if it would improve their diet quality. The main goal was to measure how healthy their eating became using a standard diet score. Researchers also checked how satisfied participants we…

This study looked at whether viruses in pregnant women with diabetes might increase the risk of congenital heart defects in their babies. Researchers analyzed blood and stool samples from 114 women to detect enteroviruses and other viruses. The goal was to gather knowledge for fu…

This study looked at whether silent myocardial ischemia (reduced blood flow to the heart without symptoms) increases the risk of heart-related death or problems in people with coronary heart disease. Researchers followed participants for one to three years to track outcomes. The …

This study looked at how eating a Western diet (high in saturated fat, fructose, and calories) for 8 weeks affects immune cells called monocytes in healthy, normal-weight adults aged 20-45. Researchers measured changes in a protein called MKP-1 and analyzed gene activity to under…

This study looked at whether certain gene changes make sudden cardiac death more likely. Researchers checked DNA from 2500 people for links to heart rhythm problems. The goal was to find genetic clues that could help predict risk, not to test a treatment.

This study compared the effects of full-fat and fat-free milk and yogurt on gut bacteria and heart disease risk. 37 adults over 50 with overweight participated. Researchers measured changes in gut microbes and blood markers to see if dairy fat content or fermentation makes a diff…