Can your genes predict blood thinner effectiveness?
NCT ID NCT03188705
First seen Jul 31, 2026 · Last updated Jul 31, 2026
Summary
This trial investigates whether genetic variations in the CES1 gene influence how the body responds to the blood thinners clopidogrel and aspirin. Healthy Amish adults will take clopidogrel for a week, then a single dose of aspirin, with blood tests measuring platelet function before and after. The goal is to understand how these genetic differences might alter drug effectiveness, which could one day help tailor antiplatelet therapy to individual patients.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Clopidogrel and aspirin
- What this could lead to
- If genetic differences are found, it could lead to personalized antiplatelet therapy, improving safety and effectiveness for people with heart disease.
- What could go wrong
- This is a small, early-phase study in healthy volunteers, so results may not apply to patients with heart disease. Genetic effects may be subtle or not clinically significant.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Amish Research Clinic
Lancaster, Pennsylvania, 17602, United States
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