CORONARY DISEASE

This study is tracking 1,000 people who receive the DESyne X2 drug-eluting stent to treat narrowed or blocked coronary arteries. Researchers are monitoring how often patients experience serious heart events like death, heart attack, or the need for another procedure. The goal is …

This study tests a new device called Freesolve, a temporary magnesium scaffold that props open blocked heart arteries and then dissolves over time. About 1,859 people with up to two new blockages will receive either this scaffold or a standard permanent stent. The goal is to see …

This study tests a special stent called PK Papyrus to repair holes (perforations) that can happen in heart arteries during procedures. About 41 people with such tears will receive the stent. The goal is to see how safe and effective it is at sealing the artery and preventing comp…

This study tests if a special device called orbital atherectomy can better prepare hardened (calcified) heart artery blockages for stenting compared to standard balloon treatment. About 200 adults with severe blockages will be randomly assigned to one of two groups. The goal is t…

This study looks at 600 people who had a major heart attack and have other narrowings in their heart arteries that are not severe but look unstable. Half will get a stent plus medication, and half will get medication alone. The goal is to see if stenting these unstable plaques re…

This study looks at whether taking just one blood thinner (single antiplatelet therapy) is safer and as effective as taking two (dual antiplatelet therapy) in older adults or those at high risk of bleeding who have had a balloon procedure to open blocked heart arteries. About 576…

This study is tracking 2,000 people with coronary artery disease who receive either a Synergy XD or Synergy Megatron stent during a routine procedure to open blocked heart arteries. Researchers want to see how these stents perform in everyday medical practice compared to other dr…

This study is testing whether doing repeated cycles of arm blood pressure cuff inflation (called remote ischemic preconditioning) over several months can improve blood flow to the heart muscle in people who have had coronary artery bypass surgery. The researchers will measure hea…

This study is testing new, lower-radiation CT scan methods for taking pictures of the heart and blood vessels. Researchers want to see if these scans are accurate at finding blocked arteries and predicting future heart problems like heart attacks. About 5,000 adults who need a he…

This study compares two non-invasive tests for coronary heart disease: a CT scan of the heart arteries versus a stress ultrasound that also checks the neck arteries. The goal is to see which test better detects blockages and prevents heart attacks or other problems. 2,000 adults …

This study looks at a new, drug-free method to measure blood flow after opening blocked heart arteries in people with multiple blockages. About 150 adults will get a standard pressure wire test plus a newer technique using contrast dye and nitroglycerin. The goal is to see if the…

This study looks at 10,000 adults aged 45 or younger who have symptoms of heart disease. Researchers will use CT scans and health information to find patterns that predict how the disease gets worse over time. The goal is to create a tool that helps doctors identify young people …