CORONARY DISEASE

This study tests two different drug-coated stents (SUPRAFLEX Cruz and SYNERGY) in about 1,550 people with severe blockages in all three main heart arteries. Participants receive a stent procedure plus modern heart care like cholesterol-lowering drugs. The goal is to see which ste…

This study tests a health behavior program for 200 people with coronary heart disease. The program combines exercise, cardiac rehab, and smartphone tools to help patients improve their walking distance, reduce frailty, and boost quality of life. Researchers hope to create a bette…

This study compares two imaging techniques, OCT and IVUS, to evaluate blockages in the left main coronary artery. Researchers aim to see if OCT can provide better measurements than IVUS to guide treatment decisions. The study involves 153 adults with moderate blockages, and will …

This study is gathering health information from 130,000 people who have had a heart attack or unstable chest pain. Researchers will analyze this data to understand which treatments work best and why. The goal is to help doctors and policymakers make better decisions for future pa…

This study followed nearly 6,000 adults aged 65 and older to learn what factors predict heart disease, stroke, and related disabilities. Researchers measured known risks like high blood pressure and diabetes to see how they affect older people's health over time. The goal was to …

This study follows 2,314 South Asian adults (ages 40-84) in the US to uncover why they have high rates of heart disease and stroke, even without typical risk factors. Researchers measure artery calcium, diabetes, and other markers over time. The goal is to identify unique causes …

This study tests whether giving doctors a special risk score—one that combines a person's genes with things like cholesterol and age—helps them make better decisions to prevent heart disease. About 1,000 people at moderate risk for heart disease but who have never had a heart att…

This study follows over 6,000 people over many years to see if traits like hostility and other emotional factors are linked to heart disease. Researchers are observing participants without giving any treatment. The goal is to better understand what leads to heart problems, not to…

This study looks at 500 women with chest pain to compare two tests used during heart catheterization—FFR and iFR—to see which one better predicts future heart problems like heart attacks or strokes. Participants will be followed for 5 years. The goal is to improve how doctors dec…

This study follows over 5,000 people with stable heart disease for up to 10 years to compare two treatment approaches: an early invasive strategy (procedures like stents or bypass surgery plus medications) versus medications alone. The goal is to see which strategy leads to fewer…

This study follows over 5,000 Black and White adults from age 18-30 for decades to see how their lifestyles and risk factors affect heart disease later in life. Researchers measure things like blood pressure, cholesterol, and weight to understand what leads to heart attacks, stro…

This study follows 2,000 people with coronary artery disease who received a Xience Sierra stent during routine care. Researchers track deaths, heart attacks, and repeat procedures to see how the stent performs compared to other stents. No extra treatments or tests are given beyon…

This study looks at whether getting an angiogram (a special X-ray of the heart arteries) 6 months after a stent procedure in the left main coronary artery can lower the risk of death, heart attack, or stroke over the next 3 years. About 400 adults aged 18-85 who received a specif…

This study looks at how ketogenic diets (like the modified Atkins diet) impact heart health in adults with epilepsy. Researchers will measure cholesterol, blood pressure, weight, and artery thickness over 12 months. About 105 adults aged 18 and older who are already on or startin…

This long-term study aims to understand how early, hidden signs of heart disease develop and predict future heart attacks, strokes, and heart failure. It follows over 6,400 adults from four different ethnic groups who started the study with no known heart disease. Researchers use…