CORONARY DISEASE

This study is testing whether performing a routine angiogram (a type of X-ray of the heart's arteries) 6 months after a stent is placed in the left main coronary artery can help reduce the risk of death, heart attack, or stroke over the next 3 years. It will involve 400 patients …

This study follows 5,391 people with stable heart disease for up to 10 years to see which initial treatment approach helps people live longer. Participants were originally assigned to either receive heart procedures plus medications or medications alone. Researchers are now track…

This study aims to see how well the Xience Sierra stent works and how safe it is for patients in real-world, everyday medical practice. It will follow 2,000 adults who have received this specific stent to treat blocked heart arteries. The main goal is to compare its performance t…

This study is testing a new health management program designed for people with coronary heart disease who are also experiencing frailty (physical weakness). The program uses exercise plans and smartphone technology to help participants get stronger, walk farther, and improve thei…

This study is comparing two different types of biodegradable heart stents (SUPRAFLEX Cruz vs. SYNERGY) in patients with severe blockages in all three major heart arteries. About 1,550 participants will have the stents placed and be followed for at least a year to see which stent …

This study compares two advanced imaging techniques—IVUS and OCT—to see which one gives doctors better information about blockages in the heart's main artery. Researchers enrolled 153 patients with moderate artery narrowing to see if the scans agree on measurements and if one sca…

This study aims to gather information to help doctors better understand which heart artery test works best for women with chest pain. Researchers will follow 500 women for 5 years to compare two different artery pressure measurements taken during heart catheterization. The goal i…

This study is testing whether a new genetic risk score helps doctors and patients manage heart disease risk better. It will follow 1,000 adults without known heart disease for 5 years to see if getting this score changes how doctors prescribe medications or order tests, and if it…

This long-term study followed nearly 5,900 adults aged 65 and older to identify what factors predict heart disease and stroke in the elderly. Researchers tracked participants' health over decades, using exams and tests to understand how risk factors like high blood pressure and c…

This is a long-term observational study that aims to understand how heart and blood vessel diseases develop in people before they show symptoms. It follows over 6,400 healthy men and women from four different ethnic backgrounds, aged 45-84, using regular scans and tests over many…

This is a long-term observational study that began in 1985 to understand how heart disease risk factors develop in young adulthood. It follows over 5,000 Black and White men and women who were 18-30 years old when they joined. The goal is to identify which lifestyle habits and ch…

This study aims to find out why people of South Asian descent have higher rates of heart disease and stroke, even when typical risk factors are accounted for. Researchers are following over 2,300 South Asian adults in the US for several years to identify new causes. The goal is t…

This study aims to understand the long-term effects of ketogenic diets on heart health in adults with epilepsy. Researchers are measuring cholesterol, blood pressure, weight, and artery wall thickness over two years. The study includes adults already on the diet and those startin…

This study is observing thousands of University of North Carolina alumni over many years to learn if personality traits like hostility and depression are connected to the development of heart disease. It is not testing a treatment; instead, it aims to gather knowledge by tracking…