Genetic test could predict heart risk before it strikes
NCT ID NCT06542432
First seen Jun 26, 2026 · Last updated Jun 26, 2026
Summary
This study looks at whether giving people a personalized genetic risk score for coronary artery disease helps doctors make better decisions about prevention. About 1,000 adults with moderate heart risk will be randomly assigned to receive their risk score or not. Researchers will track if the score leads to more use of cholesterol-lowering drugs or heart tests, and whether it lowers cholesterol levels or heart attacks over time.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- polygenic risk score (genetic test)
- What this could lead to
- If successful, this could help doctors identify people at higher risk for heart disease earlier and guide preventive treatments like cholesterol-lowering medications.
- What could go wrong
- This is an observational study, not a treatment trial. The risk score may not significantly change doctor behavior or improve health outcomes, and results may not apply to all populations.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Mayo Clinic
Rochester, Minnesota, 55905, United States
-
University of Pennsylvania
Philadelphia, Pennsylvania, 19104, United States
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