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Heart disease mystery: 6,800 diverse adults tracked for decades

NCT ID NCT00005487

Knowledge-focused Sponsor: National Heart, Lung, and Blood Institute (NHLBI) Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study followed over 6,800 adults from different racial and ethnic backgrounds to understand how heart disease develops over time. Participants were healthy at the start and were monitored for risk factors and heart-related events like heart attacks and strokes. The goal is to learn how to better predict and prevent heart disease in all populations.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

6,418 people

The number who actually took part.

Start date

Jan 1999

Expected to finish

Dec 2030

An estimate. End dates often move.

Lead sponsor

A government research agency

The lead sponsor is the US National Institutes of Health.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Participants were recruited from the MESA Study Field Centers.

Ages

45 to 84 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

CVD free men and women aged 45-84 at baseline from the four race/ethnic groups.

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Conditions

The condition(s) this trial relates to.

atherosclerosis cardiovascular disorder coronary artery disorder Coronary Disease diabetes mellitus heart disorder heart failure hypertensive disorder myocardial infarction stroke disorder type 2 diabetes mellitus

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Atherosclerosis Cardiovascular diseases Coronary artery disease Coronary disease Diabetes mellitus Diabetes mellitus type 2 Heart diseases Heart failure Hypertension Myocardial infarction Stroke

More trials for these conditions

Other studies related to the condition(s) this trial covers.