ATHEROSCLEROSIS

This study is testing whether two drugs, colchicine (an anti-inflammatory) and ticagrelor (a blood thinner), can reduce the risk of another stroke, heart attack, or related death in people who have already had an ischemic stroke. About 2,800 high-risk participants will take these…

This study tests whether choline fenofibrate can reduce plaque buildup in the carotid arteries of people with type 2 diabetes and mixed high cholesterol. About 56 participants will receive either choline fenofibrate or a comparison drug (policosanol) for several months. The main …

This study tests whether a smartphone app can help people with atherosclerosis (hardening of the arteries) stick to their new high-intensity statin medication. About 250 adults who have never taken statins before will either receive standard care or standard care plus the app. Th…

This study tests whether starting cholesterol-lowering care in the emergency department can reduce heart risks for adults aged 40-75 who are at risk for heart disease but not yet on treatment. About 130 participants will receive a guideline-based program to lower their cholestero…

This study compares two medications, clopidogrel and cilostazol, to see which better slows the thickening of neck arteries in people with type 2 diabetes. About 120 adults with diabetes and early signs of artery disease will take one of the drugs for a period. The goal is to find…

This study tests whether the drug ziltivekimab can lower inflammation in the arteries of people with heart disease. About 40 adults aged 50 and older with multiple blocked arteries and high inflammation levels will receive either the drug or a placebo. Researchers will use specia…

This study looks at whether a 12-week cardiovascular rehabilitation program (exercise training three times a week) can improve artery health and reduce inflammation in adults aged 40-70 with coronary artery disease. Researchers will measure artery thickness, blood vessel function…

This study tests whether bempedoic acid, a cholesterol-lowering drug, can reduce artery inflammation and improve heart health in people with HIV who are on effective treatment. About 121 adults aged 40 and older with controlled HIV and at least one heart risk factor will receive …

This study looks at whether adding omega-3 (fish oil) to a common cholesterol-lowering statin can reduce plaque buildup in the carotid arteries of people with type 2 diabetes and high cholesterol. About 105 adults will be randomly assigned to receive either atorvastatin plus omeg…

This early-phase trial tests an injectable drug called IMC-001 in 18 people who recently had a heart attack or unstable angina. The goal is to see if it can make fatty plaques in the arteries more stable and less likely to cause future problems. Participants receive either the dr…

This study looks at whether using just one blood thinner (single antiplatelet therapy) is safer and as effective as using two (dual antiplatelet therapy) in older adults or those at high risk of bleeding who have had a heart procedure with a drug-coated balloon. About 576 partici…

This study tests an experimental drug called selnoflast in 162 people with atherosclerosis (hardened arteries) who are at high risk for heart attacks or strokes. Participants continue their standard treatments and receive either selnoflast or a placebo. The goal is to see if seln…

This study looks at a new computer program that helps doctors diagnose blocked heart arteries from CT scans more accurately. It combines several checks into one step, which may reduce the need for invasive tests. Researchers will review past scans from 1,000 patients to see if th…

This study looks at whether the diabetes drug metformin can lower the risk of death, heart attacks, and strokes in veterans who have pre-diabetes and already have heart or blood vessel disease. About 7,400 participants will take metformin or a placebo and be followed for years. T…

This study tests whether an 8-week stress reduction program can reduce inflammation in the arteries of adults aged 30-65 who feel stressed. Researchers will use special scans to measure changes in artery inflammation. The goal is to see if managing stress can improve heart health…

This study looks at why heart disease affects women differently than men, especially after menopause. Researchers will measure inflammation and hormone levels in 6,000 women with chest pain. The goal is to understand how these factors influence heart attack risk and recovery, lea…

This study aims to learn more about rare genetic disorders that affect fat levels in the blood, such as too much or too little cholesterol or triglycerides. Researchers will follow 1,500 people aged 10 and older for up to 20 years to see how these conditions change and respond to…

This study collects sound recordings from a handheld Doppler device used in routine vascular exams. Researchers will develop a machine-learning algorithm to help doctors better interpret these signals, potentially reducing missed or incorrect diagnoses. About 180 adults already s…

This study looks at people with lipid disorders—conditions where fats like cholesterol are too high or too low in the blood. Researchers want to learn how these fats cause diseases like hardening of the arteries. Up to 2,000 adults and children (ages 2 and up) will have their blo…

This study looks at whether an 8-week stress reduction program can lower inflammation in the arteries of people with stable heart disease. About 36 adults who feel stressed will learn mindfulness techniques and get special PET/MRI scans to measure changes. The goal is to see if c…

This study looks at how eating protein might affect the buildup of plaque in arteries, which can lead to heart attacks and strokes. Researchers will study blood cells from 24 adults aged 45 to 75 to understand the mechanisms involved. The goal is to learn whether high protein int…

This study aims to better understand heart and blood vessel diseases by observing people who have them or are at risk. Researchers will collect medical information, images, and samples from up to 5,000 participants, including healthy volunteers and family members. The goal is to …

This study looks at how a gene called TMEM230 may be involved in atherosclerosis, the buildup of fatty plaques in arteries that can lead to heart attacks and strokes. Researchers will analyze blood and tissue samples from 12 adults having vascular surgery to measure gene activity…

This study aims to develop better MRI techniques for imaging the heart and blood vessels, avoiding the radiation used in standard X-ray tests. Researchers will compare these new MRI methods with traditional angiography and CT scans in up to 4,000 adults, including healthy volunte…

This study follows 2000 adults with suspected coronary artery disease who have had special imaging or pressure tests inside their heart arteries. Researchers will track major heart events like death, heart attack, or repeat procedures over many years. The goal is to learn which f…

This study looks at how the immune system's first response (innate immunity) reacts to certain environmental triggers. Researchers want to understand if these reactions are linked to long-term illnesses like asthma, heart disease, and cancer. Healthy volunteers aged 18 to 45 will…