New drug targets hidden heart risk in people with high lp(a)

NCT ID NCT07613294

Recruiting now Disease control Sponsor: Eli Lilly and Company Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Aug 07, 2026 · Updated 6 times

Summary

This study tests a drug called lepodisiran in 252 adults with high levels of Lp(a), a protein linked to heart disease. Participants must have heart disease or be at risk for a first heart event. The drug is given as an injection and compared to a placebo to see if it reduces plaque in the heart's arteries over about 2 years.

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Conditions

The condition(s) this trial relates to.

atherosclerosis atherosclerotic cardiovascular disease cardiovascular disorder coronary artery disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ATHEROSCLEROSIS CARDIOVASCULAR DISEASES LIPOPROTEIN(A)

Contacts and locations

Locations

AIM Research
RECRUITING

Merewether, 2291, Australia
Advara HeartCare - Burwood
NOT_YET_RECRUITING

Burwood, 2134, Australia
Advara HeartCare - Mulgrave
NOT_YET_RECRUITING

Mulgrave, 3170, Australia
Advara HeartCare Joondalup
NOT_YET_RECRUITING

Joondalup, 6027, Australia
Advara HeartCare Leabrook
NOT_YET_RECRUITING

Leabrook, 5068, Australia
Alrijne Ziekenhuis, locatie Leiderdorp
NOT_YET_RECRUITING

Leiderdorp, 2353 GA, Netherlands
Bristol Royal Infirmary
NOT_YET_RECRUITING

Bristol, BS2 8HW, United Kingdom
CARE Institute - High Desert
NOT_YET_RECRUITING

Meridian, Idaho, 83642, United States
CHUAC-Complejo Hospitalario Universitario A Coruña
NOT_YET_RECRUITING

A Coruña, 15001, Spain
Carilion Clinic
RECRUITING

Roanoke, Virginia, 24014, United States
Cheadle Community Hospital
NOT_YET_RECRUITING

Cheadle, ST10 1NS, United Kingdom
Clinical Site Partners, LLC dba Flourish Research
RECRUITING

Winter Park, Florida, 32789, United States
Clinitrials
RECRUITING

West Perth, 6005, Australia
Core Research Group
NOT_YET_RECRUITING

Brisbane, 4064, Australia
EFERTUS healthcare s.r.o.
NOT_YET_RECRUITING

Brno, 615 00, Czechia
Eastside Research Associates
RECRUITING

Redmond, Washington, 98052, United States
Fakultni Nemocnice u sv. Anny v Brne
NOT_YET_RECRUITING

Brno, 60200, Czechia
Fakultni Nemocnice u sv. Anny v Brne
NOT_YET_RECRUITING

Brno, 656 91, Czechia
FutureMeds - Birmingham
NOT_YET_RECRUITING

Birmingham, B21 9RY, United Kingdom
FutureMeds Teesside - Middlefield Centre
NOT_YET_RECRUITING

Stockton-on-Tees, TS19 8PE, United Kingdom
Futuremeds-Newcastle
NOT_YET_RECRUITING

Newcastle, NE6 1SG, United Kingdom
Heart and Vascular Research at WellSpan Health
NOT_YET_RECRUITING

York, Pennsylvania, 17403, United States
Hospital Clinico San Carlos
NOT_YET_RECRUITING

Madrid, 28040, Spain
Hospital General Universitario de Valencia
NOT_YET_RECRUITING

Valencia, 46014, Spain
Hospital Insular de Gran Canaria
NOT_YET_RECRUITING

Las Palmas de Gran Canaria, 35016, Spain
Hospital Quiron Barcelona
NOT_YET_RECRUITING

Barcelona, 08023, Spain
Hospital Universitario Ramón y Cajal
NOT_YET_RECRUITING

Madrid, 28034, Spain
Hospital Universitario Reina Sofia
NOT_YET_RECRUITING

Córdoba, 14004, Spain
Hospital Universitario Virgen Del Rocio
NOT_YET_RECRUITING

Seville, 41013, Spain
Hospital Universitario Virgen Macarena
NOT_YET_RECRUITING

Seville, 41009, Spain
Inpatient Research Clinic
RECRUITING

Miami Lakes, Florida, 33014, United States
Intermountain Medical Center
NOT_YET_RECRUITING

Murray, Utah, 84107, United States
Jacksonville Center for Clinical Research
NOT_YET_RECRUITING

Jacksonville, Florida, 32216, United States
Jellinger and Lerman, MD PA dba The Center for Diabetes and Endocrine Care
RECRUITING

Fort Lauderdale, Florida, 33312, United States
Lincoln County Hospital
NOT_YET_RECRUITING

Lincoln, LN2 5QY, United Kingdom
Lister Hospital
NOT_YET_RECRUITING

Stevenage, SG1 4AB, United Kingdom
Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center
NOT_YET_RECRUITING

Torrance, California, 90502, United States
Massachusetts General Hospital
NOT_YET_RECRUITING

Boston, Massachusetts, 02114, United States
Medisch Spectrum Twente
NOT_YET_RECRUITING

Enschede, 7512 KZ, Netherlands
Merritt Island Medical Research, LLC
RECRUITING

Merritt Island, Florida, 32952, United States
Nightingale Research
RECRUITING

Adelaide, 5000, Australia
Parc de Salut Mar - Hospital del Mar
NOT_YET_RECRUITING

Barcelona, 08003, Spain
Profound Research LLC
RECRUITING

Farmington Hills, Michigan, 48334, United States
Royal Lancaster Infirmary
NOT_YET_RECRUITING

Lancaster, LA1 4RP, United Kingdom
Semmelweis University
NOT_YET_RECRUITING

Budapest, 1122, Hungary
Sheffield Teaching Hospitals NHS Foundation Trust
NOT_YET_RECRUITING

Sheffield, S5 7AU, United Kingdom
Szabolcs Szatmár Bereg Vármegyei Oktatókórház
NOT_YET_RECRUITING

Nyíregyháza, 4400, Hungary
The John Radcliffe Hospital
NOT_YET_RECRUITING

Oxford, OX3 9DU, United Kingdom
Top Moravia Health
NOT_YET_RECRUITING

Brno, 61500, Czechia
UCSD - Altman Clinical and Translational Research Institute (ACTRI)
NOT_YET_RECRUITING

La Jolla, California, 92037-7410, United States
USC Clinical Trials Brisbane (South Bank)
RECRUITING

South Brisbane, 4101, Australia
University of the Sunshine Coast (UniSC) Clinical Trials - Birtinya
RECRUITING

Birtinya, 4575, Australia
Valley Clinical Trials, Inc.
RECRUITING

Northridge, California, 91325, United States
Vector Clinical Trials
RECRUITING

Las Vegas, Nevada, 89128, United States
VieCuri Medisch Centrum, locatie Venlo
NOT_YET_RECRUITING

Venlo, 5912 BL, Netherlands
Virginia Heart
NOT_YET_RECRUITING

Falls Church, Virginia, 22042, United States
Ziekenhuis St. Jansdal
NOT_YET_RECRUITING

Harderwijk, 3844 DG, Netherlands
Óbudai Egészségügyi Centrum
NOT_YET_RECRUITING

Budapest, 1036, Hungary

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