ATHEROSCLEROSIS

This Phase 3 trial is testing an oral drug called MK-0616 (enlicitide decanoate) in about 14,550 people at high risk for heart problems. The drug aims to lower cholesterol and reduce the chance of major events like heart attacks, strokes, and emergency artery procedures. Particip…

This study tests whether a comprehensive program of lifestyle changes (diet, exercise, education) plus aggressive cholesterol-lowering drugs, guided by PET heart scans, can reduce heart attacks and deaths better than standard medical care. Over 1,000 adults with suspected or know…

This study compares two ways to guide heart stent placement in people with complex artery blockages: using ultrasound (IVUS) versus standard X-ray. About 3,100 participants will be randomly assigned to one method. The goal is to see if ultrasound leads to larger stent openings an…

This study follows 250 male endurance athletes who were part of an earlier study to see how their heart arteries have changed over time. Researchers will use CT scans and AI to examine plaque buildup and determine if it is stable and harmless or likely to cause heart attacks. The…

This study tests a new way to find unstable plaques in the heart arteries of people who come to the emergency room with chest pain but are not having a heart attack. Researchers use a simple calcium scan to group patients by risk, then follow up with special PET scans to see if p…

This study looks at how high-protein drinks affect certain blood cells (monocytes and platelets) that may play a role in heart disease. Ten healthy adults will drink either a low-protein, high-protein, or leucine-added meal, and researchers will check their blood for changes in c…

This study looks at whether a computer model can predict when stents placed in the leg arteries might break or fail. Researchers will follow 30 adults who receive a stent for blocked leg arteries. The goal is to see if the model can help doctors choose the best treatment and avoi…

This study screened over 16,600 adults aged 45-70 with at least one risk factor (like high blood pressure or smoking) but no known heart disease. Researchers used ultrasound and simple blood and urine tests to find hidden signs of atherosclerosis, pre-diabetes, and kidney disease…

This study follows over 2,300 South Asian adults in the US to understand why they have high rates of heart disease and stroke, even without traditional risk factors. Participants are aged 40-84 and have no prior heart events. Researchers will track heart scans, diabetes, and othe…

This study followed over 6,800 adults from different racial and ethnic backgrounds to understand how heart disease develops over time. Participants were healthy at the start and were monitored for risk factors and heart-related events like heart attacks and strokes. The goal is t…

This study looks at whether bacteria in the gut and mouth are linked to a higher risk of stroke in people with narrowed neck arteries. Researchers will measure certain waste products from these bacteria in the blood and see if they relate to stroke or worsening artery blockages. …

This study is creating a large collection of heart images from 1,000 people who have had both a CT scan and a special camera test inside their arteries. The goal is to help researchers better understand atherosclerosis, a condition where arteries become clogged. No new treatments…

This study aimed to see if using a special pad along with a standard closure device could help patients get out of bed sooner after a heart catheterization. It was planned for adults having the procedure through the groin. However, the study was withdrawn before any participants …

This study was designed to see if a cholesterol-lowering drug called a PCSK9 inhibitor could also reduce inflammation in the arteries of people with heart disease. Researchers planned to use a special imaging scan to measure inflammation. The study was withdrawn before enrolling …