ATHEROSCLEROSIS

This study compares two ways to guide stent placement in people with complex heart artery blockages: using ultrasound (IVUS) versus standard X-ray (angiography). The goal is to see if ultrasound leads to larger, better-placed stents and fewer heart-related problems like heart att…

This study compares a comprehensive program of lifestyle changes, cholesterol-lowering drugs, and PET heart scans against standard medical care for people with stable coronary artery disease. About 1,085 adults aged 40 and older with suspected or known heart disease are participa…

This study follows 2,314 South Asian adults (ages 40-84) in the US to uncover why they have high rates of heart disease and stroke, even without typical risk factors. Researchers measure artery calcium, diabetes, and other markers over time. The goal is to identify unique causes …

This study tests a new way to find unstable plaque in the heart arteries of people who come to the emergency room with chest pain but are not having a heart attack. Researchers will use a calcium score scan and a special PET scan to see which patients have hidden risky plaque. Th…

This study screened over 16,600 adults in Spain (ages 45-70) with at least one risk factor (like high blood pressure or smoking) but no known heart disease. Half received advanced ultrasound and urine tests to find hidden artery and kidney problems. The goal is to see if early de…

This study tests a computer model that predicts whether a stent placed in the leg artery will break or fail. Researchers will follow 30 adults with blocked leg arteries who receive a stent. The goal is to help doctors choose the best treatment for each patient.

This study collects heart images (like CT scans and angiograms) from 1000 people to create a database for future research. The goal is to better understand atherosclerosis, a condition where arteries get clogged. No new treatments or medications are being tested.

This study was designed to see if a cholesterol-lowering drug called a PCSK9 inhibitor could also reduce inflammation in the arteries of people with heart disease. Researchers planned to use a special imaging scan to measure inflammation. However, the study was withdrawn before e…

This study looks at whether bacteria in the gut and mouth are linked to a higher risk of stroke in people with narrowed neck arteries. Researchers will measure certain waste products from bacteria in the blood and track who has a stroke over time. No new treatments are being test…

This study was designed to see if using a special pad along with a standard closure device could speed up artery sealing and reduce bed rest after a heart catheterization. It planned to enroll adults undergoing the procedure through the leg artery. However, the study was withdraw…

This long-term study aims to understand how early, hidden signs of heart disease develop and predict future heart attacks, strokes, and heart failure. It follows over 6,400 adults from four different ethnic groups who started the study with no known heart disease. Researchers use…