Can a supercharged lifestyle program beat standard heart care?

NCT ID NCT00756379

Ongoing Disease control Sponsor: The University of Texas Health Science Center, Houston Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether a comprehensive program of lifestyle changes (diet, exercise, education) plus aggressive cholesterol-lowering drugs, guided by PET heart scans, can reduce heart attacks and deaths better than standard medical care. Over 1,000 adults with suspected or known coronary artery disease will be followed for 5 years. The goal is to see if this intensive approach improves heart health and is cost-effective.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: comprehensive lifestyle modification program (diet, exercise, education) plus lipid-lowering drugs
What this could lead to: If successful, this could show that an intensive lifestyle and medication program, guided by PET scans, reduces heart attacks and deaths more than standard care.
What could go wrong: This is a single-center study, so results may not apply everywhere. The program is intensive and may be hard for many people to follow long-term.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

atherosclerosis cardiovascular disorder coronary artery disorder coronary stenosis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ATHEROSCLEROSIS CARDIOVASCULAR DISEASE CORONARY ARTERY DISEASE CORONARY STENOSIS

Contacts and locations

Locations

Weatherhead PET Center, Memorial Hermann Hospital TMC

Houston, Texas, 77030, United States

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