The University Of Texas Health Science Center, Houston

This study is testing if a weekly injection called semaglutide can help adults who are quitting smoking avoid gaining weight. Researchers want to see if the medication helps control appetite and food intake during the challenging period after stopping cigarettes. The trial will e…

This small pilot study is testing whether a combination of non-invasive brain stimulation and a mental training technique can help people with methamphetamine addiction. Researchers will use a magnetic device on the scalp (rTMS) while participants practice vividly imagining posit…

This study investigates whether giving a common heartburn medication (pantoprazole) very early can help prevent kidney damage in trauma patients who have gone into shock from severe bleeding. Researchers will compare early treatment against usual care in 100 adult patients. They …

This study aims to find out if stopping the routine use of inhaled nitric oxide (a gas treatment to help with breathing) during the initial stabilization of newborns with a congenital diaphragmatic hernia affects their survival or need for advanced life support. It will involve a…

This study is testing whether a freeze-dried fecal microbiota transplant (FMT) capsule, taken by mouth, can help prevent relapse in adults with ulcerative colitis who are currently in remission. Participants will take the FMT pills or a placebo for 12 weeks while staying on their…

This study is testing if adding the medication pioglitazone to standard talk therapy (CBT) can better help people stay off cocaine after they've recently quit. Researchers want to see if the drug can help repair brain damage from cocaine use, which might make the therapy more eff…

This study is testing whether using smaller tubes to collect blood for lab tests can reduce the need for blood transfusions in intensive care patients with anemia. Researchers will compare patients using the small tubes to those using standard tubes to see if it lowers transfusio…

This study is testing if semaglutide, a medication currently used for diabetes and weight loss, can help people with cocaine addiction. Researchers will give the drug alongside cognitive behavioral therapy to 75 participants to see if it reduces cravings and actual cocaine use. T…

This study compares two different ways to monitor muscle relaxation during surgery to see which one better prevents breathing problems after the operation. Researchers will test both methods on over 1,000 adults receiving general anesthesia with muscle relaxants. The goal is to f…

This study is testing a three-part treatment for advanced pancreatic cancer that cannot be removed by surgery. Doctors will first use a special ultrasound probe to heat and destroy the main tumor, then give standard chemotherapy along with an immunotherapy drug called pembrolizum…

This study is testing whether a very low dose of the weight loss medication semaglutide can help people with HIV keep weight off after they lose it. Researchers will compare weight regain in 30 participants who either receive the low-dose drug or no additional medication for a ye…

This study is testing whether a patch made from a newborn's own umbilical cord tissue can improve the surgical repair of spina bifida. Researchers will use the tissue to close the spinal opening in 15 newborns, aiming to create a better spinal canal and reduce complications. They…

This study is testing two types of magnetic brain stimulation to help people with schizophrenia quit smoking. Researchers believe the high smoking rates in this group may be due to overlapping brain circuits for addiction and schizophrenia. They will measure changes in brain acti…

This study tests a community program that helps young people with opioid addiction get treatment faster. The program sends outreach teams to connect youth with medication, counseling, and peer support right away. Researchers want to see if this approach helps young people stay in…

This early-stage study is testing whether a dietary supplement called nicotinamide riboside (NR) can help people with a rare genetic condition called Smooth Muscle Dysfunction Syndrome (SMDS). The condition causes problems with blood vessels in the brain and body. Researchers wil…

This study aims to find out which of two dental cleaning systems, GentleWave or EdgePro, is better at reducing bacteria in infected root canals. It will involve 30 adults who need a root canal treatment on a permanent tooth with dead, infected pulp. Researchers will measure how m…

This study aims to find the best starting humidity level in incubators for babies born before 25 weeks of pregnancy. Researchers will compare a higher humidity setting (90%) to a lower one (70%) for 350 infants. The goal is to see if higher humidity reduces early weight loss from…

This study is testing if using a structured checklist when anesthesia providers change shifts during surgery can help prevent serious complications after the operation. It will involve 4,500 patients having non-heart surgery. The main goal is to see if this tool reduces problems …

This study compares two different bone graft methods used during cleft lip and palate repair surgery. Researchers want to see if using a lab-made bone material causes less pain, shorter surgery times, and similar healing compared to taking bone from the patient's hip. They'll als…

This study aims to see if new, faster laboratory tests can better detect syphilis in pregnant women and their newborns compared to current standard methods. Researchers will enroll about 924 mother-baby pairs at risk for syphilis to compare the accuracy of these new tests. The go…

This study is testing if a new blood test helps doctors in the emergency room quickly tell if a respiratory infection is caused by bacteria or a virus. The goal is to see if having this information early leads to better decisions about antibiotics, hospital stays, and other tests…

This study is testing a new wrist-worn device called ViTrack that aims to measure blood pressure continuously without needles. It will be tested on 40 people who are already scheduled for surgery and need standard invasive blood pressure monitoring. The main goal is to see how ac…

This study is testing a new set of tools and processes designed to help primary care doctors more accurately and quickly diagnose the causes of abnormal blood test results, specifically low hemoglobin (anemia) and low kidney function. The research involves 450 patients and their …

This study aims to prevent suicide by firearm. Researchers are working with gun store owners, shooting range owners, and healthcare providers to test messages about safe gun storage. They want to see if these messages are acceptable and might encourage people to store guns safely…

This study is testing if rinsing the abdomen with a common antiseptic called povidone-iodine during surgery for a burst appendix can prevent painful internal abscess infections. It will also check if this simple step saves money for patients and the healthcare system. The trial w…

This study is testing a new hospital-based program designed to prevent people from getting violently injured again after being treated for a gunshot wound. Researchers will enroll 274 young people (ages 16-35) who were shot and randomly assign them to either receive the new suppo…

This study is testing a two-week, completely remote treatment program for people suffering from both chronic pain and PTSD. Researchers want to see if combining a mild, non-invasive brain stimulation technique with a specialized talk therapy is more effective than the therapy alo…

This small pilot study is testing whether a vibrating capsule, already approved for chronic constipation, is safe and helpful for people with spinal cord injuries who have severe bowel problems. Researchers will give the capsule to 12 participants to see if it can be used safely …

This study is testing whether a safe, non-invasive brain stimulation device can be used at home by people with Huntington's disease. The main goal is to see if this approach is practical and acceptable, and if it might help ease common symptoms like mood changes, thinking problem…

This study is testing a cooking class program for people who are in recovery from opioid use and living in recovery homes in Texas. The goal is to see if learning about nutrition and gaining cooking skills can help improve their diet and confidence. Researchers will measure chang…

This study is testing whether a non-invasive brain stimulation treatment can help reduce depression symptoms in people living with schizophrenia. Researchers will use a magnetic coil placed on the head to stimulate specific brain areas thought to be involved in depression. The go…

This study is testing whether magnetic brain stimulation can help improve the emotional and social withdrawal symptoms of schizophrenia. Researchers will compare stimulation of two different brain areas against a sham (fake) treatment in 20 participants. The goal is to see if thi…

This study is testing a program called 'Launching! to Adulthood' to see if it helps young adults with autism improve their daily living skills, social interactions, and readiness for adult life. Researchers will compare the program to a delayed treatment group and measure changes…

This study is testing if a gentle, non-invasive stimulation of a nerve in the ear (taVNS) is safe and practical when used alongside standard hand and arm therapy for people with chronic spinal cord injury. The main goal is to see if the combination is well-tolerated and if partic…

This study is testing whether a gentle, non-invasive brain stimulation technique (tDCS) can help people with bipolar depression who struggle to feel pleasure or motivation (anhedonia). Researchers will use brain scans to personalize the treatment and see if it changes specific br…

This small pilot study is testing if a prescription sleep medication called suvorexant can help people in early recovery from cocaine or methamphetamine addiction. Researchers want to see if better sleep leads to less stress, fewer cravings, and helps people stay longer in their …

This study is testing if adding the pain medication Ketorolac to the usual pain care helps infants drink more fluids after cleft palate repair surgery. Researchers will compare two groups of infants: one gets the usual pain medications, and the other gets the usual medications pl…

This study is testing a smartphone app that teaches people to use ear acupressure to manage their own chronic pain. It will involve 693 adults from rural areas who have long-term pain in areas like their back, neck, or knees. Researchers will compare learning the technique throug…

This study is creating a large patient registry to understand and improve real-world care for people with Multiple Sclerosis (MS). It will collect health records from up to 2,000 participants to track how disability and thinking problems change over time. The goal is to use this …

This study aims to find out if giving extra vitamin D to extremely premature infants during their first month of life improves their health. Researchers will compare a daily vitamin D supplement to usual care in 50 babies born before 28 weeks or weighing less than 2.2 pounds. The…

This study aims to see if a protein linked to Alzheimer's disease (called pTau217) is present in donated blood. Researchers will test about 250 blood plasma samples from a blood bank to measure how common this protein is. The goal is to gather information to help determine if blo…

This study aims to build a large national registry of people with severe headache disorders like cluster headache and trigeminal neuralgia. Researchers will collect detailed health information, genetic data, and survey results from up to 1,500 participants to better understand th…

This study aims to understand how the brain processes fear in people with PTSD. Researchers will test a gentle, non-invasive brain stimulation technique to see if it can calm overactive fear networks and reduce symptoms like anxiety and hypervigilance. The study will compare 80 p…

This study is looking at whether switching to a clear liquid diet for 24 hours before an upper endoscopy procedure can reduce the amount of stomach contents in patients taking GLP-1 receptor agonist drugs (like Ozempic or Wegovy). Researchers want to see if this diet lowers the r…

This study aims to understand how the brain creates the experience of pain. Researchers will use brain scans and mild electrical stimulation on healthy volunteers while applying pressure to measure pain. The goal is to learn more about the brain circuits involved in pain, which c…

This study creates a registry to collect information on the care and outcomes of extremely premature babies born at 22-23 weeks of pregnancy. It involves up to 5,000 mothers and infants from multiple hospitals. The goal is to gather data on treatments and results to help hospital…

This study aims to understand why people respond differently to a natural hormone (GLP-1) that helps control blood sugar and weight. Researchers will study 300 Mexican-American adults with prediabetes to see how their genes affect their body's response to this hormone. The goal i…

This study aims to better understand the risks and progression of inherited aortic diseases, which can lead to dangerous aneurysms and dissections. It will follow 5,000 people worldwide who have specific genetic mutations linked to these conditions. The goal is to gather detailed…

This study aims to understand how the brain works in people with PTSD and test if a gentle, non-invasive electrical brain stimulation can help calm anxiety and hypervigilance. Researchers will compare 80 healthy adults and 80 people with PTSD, giving some the real stimulation and…

This study aims to better understand bipolar disorder in young people. Researchers will enroll 1000 children and teens, including those with bipolar disorder, those with a parent who has it, and healthy volunteers. They will collect blood and saliva samples, perform brain scans, …