The University Of Texas Health Science Center, Houston

This study tests whether the drug Fintepla (fenfluramine) can improve how the brain and lungs respond to carbon dioxide in people with Dravet syndrome, a severe epilepsy. Poor responses to CO2 may increase the risk of sudden unexpected death in epilepsy (SUDEP). Twenty-five parti…

This study tests whether adding a simple stitch to support the top of the vagina during a scarless hysterectomy (vNOTES) can help prevent pelvic organ prolapse later on. Fifty women having a vNOTES hysterectomy for non-cancer reasons will be enrolled. The surgeons will measure va…

This study will test a rapid fingerstick test for HIV and syphilis in pregnant women who come to the emergency department without prior prenatal care. Researchers want to see if offering this test leads to more women being diagnosed and starting treatment right away. The goal is …

This study looks at ways to improve care for teens and young adults who have experienced sexual assault. The goal is to offer same-day HIV prevention medicine and substance use support during their emergency room visit. Researchers will work with young people to design and test t…

This study tests whether giving high-risk pregnant women free deliveries of fresh produce, lean protein, and whole grains—plus nutrition classes—can prevent gestational diabetes. Researchers will enroll 400 women receiving care at Harris Health clinics who are early in pregnancy …

This study tests a device called BreEStim that uses electrical stimulation timed with your breathing to reduce nerve pain after spinal cord injury. About 66 adults with long-term spinal cord injury and stable pain will receive either active or sham treatment. The goal is to see i…

This study tests a therapy called Mentalizing Imagery Therapy (MIT) for family caregivers of people with Alzheimer's or related dementias. The goal is to see if it can lower stress, depression, and the risk of elder mistreatment. About 50 caregivers who provide at least 8 hours o…

This study will test whether using a virtual reality (VR) headset for cognitive and physical exercises is practical and well-liked by people with mild cognitive impairment. Ten participants will do three supervised VR sessions per week for six weeks. The goal is to see if they ca…

This study tests a 16-week exercise program designed specifically for Hispanic people with multiple sclerosis who have walking problems. About 66 participants will either join the exercise group or a waitlist. The goal is to see if the program improves walking ability and quality…

This study tests whether a virtual home rehabilitation program helps stroke survivors in underserved Texas communities recover better than standard care alone. About 80 adults who recently had a stroke and are returning home will take part. The program uses video sessions to guid…

This study tests a daily testosterone gel to see if it can safely improve sexual interest and arousal in women going through menopause. Researchers will compare the gel to a placebo in 150 women aged 40-65 who have been diagnosed with low sexual desire. The goal is to provide a m…

This study tests a personalized version of a therapy called Stepped Care Cognitive Behavioral Therapy for children who have experienced trauma. The therapy is adapted for Latino families and involves caregivers helping their children through a step-by-step process. Researchers wi…

This pilot study tests a personalized version of stepped-care cognitive behavioral therapy for PTSD in Latino children aged 7-12. The therapy involves a caregiver-led first step with therapist support, followed by more intensive therapy if needed. The goal is to see if adapting t…

This study looks at whether a procedure called microneedling radiofrequency (which uses tiny needles and heat) can improve skin and fat thickness in the face, and if adding a topical cream (poly-L-lactic acid) makes it work better. About 30 adults seeking facial rejuvenation will…

This study tests a simple screening tool to help doctors find muscle stiffness (spasticity) sooner after a stroke. Researchers will track how quickly spasticity is detected and whether the tool helps doctors make faster treatment decisions. About 80 adults who recently had a stro…

This study will test whether continuously monitoring vital signs like oxygen levels and heart rate after major surgery can reduce complications compared to standard intermittent checks. About 492 adults having non-cardiac surgery will be randomly assigned to either have their dat…

This study looks at how often people develop allergic skin reactions to two different wound dressings used after open shoulder surgery: one made from silk protein and another from a medical glue mesh. About 350 adults having shoulder surgery will be randomly assigned to one dress…

This study looks at whether a program called MAGIC, which adds short physical activity breaks and lessons into the school day, can help elementary students be more active and lower their risk for heart problems. Researchers will track how well teachers use the program and measure…

This study looks at how raising or lowering the bite (occlusal vertical dimension) with special splints changes the lower face and lips. Fifty adults with full dentures will have their bite temporarily adjusted and their face scanned in 3D. The goal is to understand how bite heig…

This study will test an online tool called iCHAMPS-YVP that helps Texas school staff choose and put into practice proven programs to prevent bullying and teen dating violence. Researchers will work with 25 school administrators, teachers, and counselors to see if the tool is easy…

This pilot study will test whether an artificial intelligence tool can give helpful feedback to medical residents about how they talk with patients. Sixty-four surgery residents will have their conversations with actors playing patients recorded and analyzed by a large language m…

This study will test a device called GentleWave that is designed to clean root canals more effectively, especially in hard-to-reach areas. Researchers will use 50 teeth that are already scheduled for extraction. After a partial root canal treatment with GentleWave, the teeth will…

This study will test a mobile app called ¡Iniciando! designed to help Latino young adults with autism and their families navigate the move to adulthood. The app includes virtual group sessions and coaching over 12 weeks. The goal is to see if the app is easy to use, acceptable, a…