Can a beam of light banish toenail fungus?
NCT ID NCT07756671
First seen Aug 11, 2026 · Last updated Aug 12, 2026 · Updated 1 time
Summary
This trial tests whether photodynamic therapy (PDT) can clear toenail fungus. People with a confirmed fungal nail infection will have a special gel applied to the affected nail, then exposed to red light. The study will check if the nail looks healthy and if the fungus is gone at several follow-up points over a year.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Photodynamic therapy using aminolevulinic acid (ALA) 10% gel and red light, with urea pretreatment
- What this could lead to
- If successful, this could offer a non-drug, light-based option for clearing toenail fungus, potentially helping people who can't take oral antifungals.
- What could go wrong
- This is a very small early-phase trial (5 people), so results may not apply broadly. The treatment may not fully clear the infection, and side effects like skin reactions are possible.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Arlington Center for Dermatology
Arlington, Texas, 76011, United States
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Houston Skin
Houston, Texas, 77004, United States
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Houston Skin
Webster, Texas, 77598, United States
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