New light therapy takes on stubborn toenail fungus
NCT ID NCT03098342
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tested two treatments for toenail fungus in 27 Asian adults: a light-activated dye (methylene blue photodynamic therapy) and a medicated nail polish (amorolfine). The goal was to see which worked better and was safer. Participants received either the light treatment or the polish, and doctors used special photos to measure improvement.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- methylene blue (used in photodynamic therapy) and amorolfine nail lacquer
- What this could lead to
- If successful, this could offer a new, non-drug treatment option for stubborn toenail fungus, potentially with fewer side effects than long-term antifungal pills.
- What could go wrong
- This is a small, completed study with only 27 participants, so results may not apply to everyone. Photodynamic therapy requires multiple clinic visits and may cause temporary pain or redness.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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King Chulalongkorn Memorial Hospital
Bangkok, Bangkok, 10330, Thailand
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